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Comparison of myocardial T1 mapping during breath-holding and free-breathing

Published online by Cambridge University Press:  09 August 2021

Hideharu Oka Open the ORCID record for Hideharu Oka [Opens in a new window] ,
Kouichi Nakau ,
Sadahiro Nakagawa ,
Yuki Kobayashi ,
Rina Imanishi ,
Kunihiro Iwata  and
Hiroshi Azuma
Hideharu Oka*
Affiliation:
Department of Pediatrics, Asahikawa Medical University, Hokkaido, Japan
Kouichi Nakau
Affiliation:
Department of Pediatrics, Asahikawa Medical University, Hokkaido, Japan
Sadahiro Nakagawa
Affiliation:
Section of Radiological Technology, Department of Medical Technology, Asahikawa Medical University Hospital, Hokkaido, Japan
Yuki Kobayashi
Affiliation:
Asahikawa Medical University, Hokkaido, Japan
Rina Imanishi
Affiliation:
Department of Pediatrics, Asahikawa Medical University, Hokkaido, Japan
Kunihiro Iwata
Affiliation:
Section of Radiological Technology, Department of Medical Technology, Asahikawa Medical University Hospital, Hokkaido, Japan
Hiroshi Azuma
Affiliation:
Department of Pediatrics, Asahikawa Medical University, Hokkaido, Japan
*
Author for correspondence: Hideharu Oka, Department of Pediatrics, Asahikawa Medical University, 2-1-1-1, Midorigaoka-Higashi, Asahikawa, 078-8510, Japan. Tel: +81-16668-2481; Fax: +81-16668-2489. E-mail: oka5p@asahikawa-med.acjp
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Abstract

Background:

T1 mapping is a recently developed imaging analysis method that allows quantitative assessment of myocardial T1 values obtained using MRI. In children, MRI is performed under free-breathing. Thus, it is important to know the changes in T1 values between free-breathing and breath-holding. This study aimed to compare the myocardial T1 mapping during breath-holding and free-breathing.

Methods:

Thirteen patients and eight healthy volunteers underwent cardiac MRI, and T1 values obtained during breath-holding and free-breathing were examined and compared. Statistical differences were determined using the paired t-test.

Results:

The mean T1 values during breath-holding were 1211.1 ± 39.0 ms, 1209.7 ± 37.4 ms, and 1228.9 ± 52.5 ms in the basal, mid, and apical regions, respectively, while the mean T1 values during free-breathing were 1165.1 ± 69.0 ms, 1103.7 ± 55.8 ms, and 1112.0 ± 81.5 ms in the basal, mid, and apical regions, respectively. The T1 values were lower during free-breathing than during breath-holding in almost all segments (basal: p = 0.008, mid: p < 0.001, apical: p < 0.001). The mean T1 values in each cross section were 3.1, 7.8, and 7.7% lower during free-breathing than during breath-holding in the basal, mid, and apical regions, respectively.

Conclusions:

We found that myocardial T1 values during free-breathing were about 3–8% lower in all cross sections than those during breath-holding. In free-breathing, it may be difficult to assess myocardial T1 values, except in the basal region, because of underestimation; thus, the findings should be interpreted with caution, especially in children.

Keywords

T1 mappingfree-breathingbreath-holdingCardiac MRIrespiratory motion
Type
Original Article
Information
Cardiology in the Young , Volume 32 , Issue 6 , June 2022 , pp. 925 - 929
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Copyright
© The Author(s), 2021. Published by Cambridge University Press

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References

Taylor, AJ, Salerno, M, Dharmakumar, R, et al. T1 mapping: basic techniques and clinical applications. JACC Cardiovasc Imaging 2016; 9: 67–81.CrossRefGoogle ScholarPubMed
Reiter, U, Reiter, C, Kräuter, C, et al. Cardiac magnetic resonance T1 mapping. Part 2: diagnostic potential and applications. Eur J Radiol 2018; 109: 235–247.CrossRefGoogle ScholarPubMed
Jafari, F, Safaei, AM, Hosseini, L, et al. The role of cardiac magnetic resonance imaging in the detection and monitoring of cardiotoxicity in patients with breast cancer after treatment: a comprehensive review. Heart Fail Rev 2020. doi: 10.1007/s10741-020-10028-y.CrossRefGoogle Scholar
Martin-Garcia, A, Diaz-Pelaez, E, Lopez-Corral, L, et al. T2 mapping identifies early anthracycline-induced cardiotoxicity in elderly patients with cancer. JACC Cardiovasc Imaging 2020; 13: 1630–1632.CrossRefGoogle ScholarPubMed
Slomka, PJ, Fieno, D, Ramesh, A, et al. Patient motion correction for multiplanar, multi-breath-hold cardiac cine MR imaging. J Magn Reson Imaging 2007; 25: 965–973.CrossRefGoogle ScholarPubMed
Messroghli, DR, Radjenovic, A, Kozerke, S, et al. Modified Look-Locker inversion recovery (MOLLI) for high-resolution T1 mapping of the heart. Magn Reson Med 2004; 52: 141–146.CrossRefGoogle ScholarPubMed
Cerqueira, MD, Weissman, NJ, Dilsizian, V, et al. Standardized myocardial segmentation and nomenclature for tomographic imaging of the heart. A statement for healthcare professionals from the Cardiac Imaging Committee of the Council on Clinical Cardiology of the American Heart Association. Circulation 2002; 105: 539–542.Google Scholar
Kellman, P, Hansen, MS. T1-mapping in the heart: accuracy and precision. Cardiovasc Magn Reson 2014; 16: 2.CrossRefGoogle ScholarPubMed
Xue, H, Shah, S, Greiser, A, et al. Motion correction for myocardial T1 mapping using image registration with synthetic image estimation. Magn Reson Med 2012; 67: 1644–1655.CrossRefGoogle ScholarPubMed
Rauhalammi, SM, Mangion, K, Barrientos, PH, et al. Native myocardial longitudinal (T1) relaxation time: regional, age, and sex associations in the healthy adult heart. J Magn Reson Imaging 2016; 44: 541–548.CrossRefGoogle ScholarPubMed
Dabir, D, Child, N, Kalra, A, et al. Reference values for healthy human myocardium using a T1 mapping methodology: results from the International T1 Multicenter cardiovascular magnetic resonance study. J Cardiovasc Magn Reson 2014; 16: 69.CrossRefGoogle ScholarPubMed
Bush, MA, Pan, Y, Jin, N, et al. Prospective correction of patient-specific respiratory motion in myocardial T1 and T2 mapping. Magn Reson Med 2020. doi: 10.1002/mrm.28475.CrossRefGoogle Scholar