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Comparison of myocardial T1 mapping during breath-holding and free-breathing

Published online by Cambridge University Press:  09 August 2021

Hideharu Oka Open the ORCID record for Hideharu Oka [Opens in a new window] ,
Kouichi Nakau ,
Sadahiro Nakagawa ,
Yuki Kobayashi ,
Rina Imanishi ,
Kunihiro Iwata  and
Hiroshi Azuma
Hideharu Oka*
Affiliation:
Department of Pediatrics, Asahikawa Medical University, Hokkaido, Japan
Kouichi Nakau
Affiliation:
Department of Pediatrics, Asahikawa Medical University, Hokkaido, Japan
Sadahiro Nakagawa
Affiliation:
Section of Radiological Technology, Department of Medical Technology, Asahikawa Medical University Hospital, Hokkaido, Japan
Yuki Kobayashi
Affiliation:
Asahikawa Medical University, Hokkaido, Japan
Rina Imanishi
Affiliation:
Department of Pediatrics, Asahikawa Medical University, Hokkaido, Japan
Kunihiro Iwata
Affiliation:
Section of Radiological Technology, Department of Medical Technology, Asahikawa Medical University Hospital, Hokkaido, Japan
Hiroshi Azuma
Affiliation:
Department of Pediatrics, Asahikawa Medical University, Hokkaido, Japan
*
Author for correspondence: Hideharu Oka, Department of Pediatrics, Asahikawa Medical University, 2-1-1-1, Midorigaoka-Higashi, Asahikawa, 078-8510, Japan. Tel: +81-16668-2481; Fax: +81-16668-2489. E-mail: oka5p@asahikawa-med.acjp
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Abstract

Background:

T1 mapping is a recently developed imaging analysis method that allows quantitative assessment of myocardial T1 values obtained using MRI. In children, MRI is performed under free-breathing. Thus, it is important to know the changes in T1 values between free-breathing and breath-holding. This study aimed to compare the myocardial T1 mapping during breath-holding and free-breathing.

Methods:

Thirteen patients and eight healthy volunteers underwent cardiac MRI, and T1 values obtained during breath-holding and free-breathing were examined and compared. Statistical differences were determined using the paired t-test.

Results:

The mean T1 values during breath-holding were 1211.1 ± 39.0 ms, 1209.7 ± 37.4 ms, and 1228.9 ± 52.5 ms in the basal, mid, and apical regions, respectively, while the mean T1 values during free-breathing were 1165.1 ± 69.0 ms, 1103.7 ± 55.8 ms, and 1112.0 ± 81.5 ms in the basal, mid, and apical regions, respectively. The T1 values were lower during free-breathing than during breath-holding in almost all segments (basal: p = 0.008, mid: p < 0.001, apical: p < 0.001). The mean T1 values in each cross section were 3.1, 7.8, and 7.7% lower during free-breathing than during breath-holding in the basal, mid, and apical regions, respectively.

Conclusions:

We found that myocardial T1 values during free-breathing were about 3–8% lower in all cross sections than those during breath-holding. In free-breathing, it may be difficult to assess myocardial T1 values, except in the basal region, because of underestimation; thus, the findings should be interpreted with caution, especially in children.

Keywords

T1 mappingfree-breathingbreath-holdingCardiac MRIrespiratory motion
Type
Original Article
Information
Cardiology in the Young , Volume 32 , Issue 6 , June 2022 , pp. 925 - 929
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Copyright
© The Author(s), 2021. Published by Cambridge University Press

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