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Diastolic function in anthracycline-treated children

Published online by Cambridge University Press:  23 September 2014

Ashraf Harahsheh ,
Sanjeev Aggarwal ,
Michael D. Pettersen  and
Thomas L’Ecuyer
Ashraf Harahsheh*
Affiliation:
Department of Pediatrics, Division of Cardiology, Children’s National Health System, The George Washington University School of Medicine, Washington, District of Columbia, United States of America
Sanjeev Aggarwal
Affiliation:
Department of Pediatrics, Division of Cardiology, Children’s Hospital of Michigan, Wayne State University, Detroit, Michigan, United States of America
Michael D. Pettersen
Affiliation:
Rocky Mountain Pediatric Cardiology, Denver, Colorado, United States of America
Thomas L’Ecuyer
Affiliation:
Department of Pediatrics, Division of Cardiology, University of Virginia Health System, Charlottesville, Virginia, United States of America
*
Correspondence to: A. Harahsheh, MD, FACC, FAAP, Division of Cardiology, George Washington University, Center for Heart, Lung and Kidney Disease, Children’s National Health System, 111 Michigan Avenue, N.W. Washington, DC 20010, United States of America. Tel: +202 476 2020; Fax: +202 476 5700; Email: AHarahsh@childrensnational.org
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Abstract

Background: Anthracyclines are effective medications for childhood cancer. Their limitation is the risk of cardiomyopathy. Although diastolic dysfunction has been described in patients who received anthracyclines, cardiac monitoring has focused on systolic function, which is abnormal in up to 41% of the patients. We conducted a study to assess diastolic function utilising transmitral inflow Doppler velocities and tissue Doppler imaging in anthracycline-treated children 5 years post-therapy. Methods: This was a retrospective study on 63 anthracycline-treated patients. Echocardiographic parameters included peak early and late transmitral inflow Doppler velocities (E, A), E/A ratio, E deceleration time, and tissue Doppler imaging early and late diastolic mitral annulus velocities (E′, A′), E/E′ ratio, and E′/A′ ratio. Results: All indices of diastolic function that we measured were normal in the anthracycline-treated patients. Conclusion: We conclude that diastolic function assessed by transmitral inflow Doppler velocities and tissue Doppler imaging is normal in anthracycline-treated children 5 years after completion of treatment. Further longitudinal study is needed to determine whether diastolic function becomes abnormal with time in this patient population.

Keywords

Cardiomyopathyechocardiogramtissue Doppler imagingpaediatric cardiology
Type
Original Articles
Information
Cardiology in the Young , Volume 25 , Issue 6 , August 2015 , pp. 1130 - 1135
Copyright
© Cambridge University Press 2014 

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Footnotes

a

Dr Harahsheh was a fellow at Children’s Hospital of Michigan, Wayne State University, Detroit, Michigan, United States of America at the time of conducting this study.

b

Drs Pettersen and L’Ecuyer were attending physicians at Children’s Hospital of Michigan, Wayne State University, Detroit, Michigan, United States of America at the time of conducting this study.

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