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Dimensions of the pulmonary arteries in rat fetuses with congenital heart disease

Published online by Cambridge University Press:  19 August 2008

Kazuo Momma ,
Masahiko Ando  and
Masaaki Yoshigi
Kazuo Momma*
Affiliation:
From the Department of Pediatric Cardiology, The Heart Institute ofJapan, Tokyo Women's Medical College, Tokyo
Masahiko Ando
Affiliation:
From the Department of Pediatric Cardiology, The Heart Institute ofJapan, Tokyo Women's Medical College, Tokyo
Masaaki Yoshigi
Affiliation:
From the Department of Pediatric Cardiology, The Heart Institute ofJapan, Tokyo Women's Medical College, Tokyo
*
Dr. Kazuo Momma, Department of Pediatric Cardiology, The Heart Institute of Japan, Tokyo Women's Medical College, 8–1 Kawada-cho, Shinjuku-ku, Tokyo 162, Japan. Tel. 03-3353-8111; Fax. 03-3356-0441.
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Abstract

So as to understand better the pathogenesis of enlargement or hypoplasia of pulmonary arteries in congenital heart disease, we studied the dimensions of the pulmonary arteries in 74 fetuses with congenital heart disease induced by administration of bis-diamine to pregnant rats. The congenital malformations induced included 12 with large ventricular septal defect, 17 with tetralogy of Fallot, 15 with tetralogy together with severe valvar pulmonary stenosis and absence of the arterial duct, 17 with tetralogy with absent pulmonary valve syndrome and absence of the arterial duct, and 13 with common arterial trunk with a confluent segment supplying the pulmonary arteries. For comparison, 16 fetuses of the same gestational age with normal hearts were studied. After rapid whole-body freezing on the 21st day of gestation, the fetuses were studied by means of serial cross-sectional photographs of the thorax. The diameter of the right pulmonary artery of the fetus was of comparable dimensions in the normal hearts (480±10 µm) (mean±SEM), those with ventricular septal defects (470±10 µm), common arterial trunk (520±20 µm), and tetralogy of Fallot (500±10 µm). These findings suggest that the commonly observed enlargement of the right pulmonary artery in patients with ventricular septal defect and common arterial trunk, and hypoplasia of the right pulmonary artery in tetralogy of Fallot, occur postnatally in response to abnormal postnatal pulmonary blood flow.

Keywords

Fetuspulmonary arterytetralogy of Fallotabsent pulmonary valvecommon arterial trunkventricular sepral defect
Type
Original Articles
Information
Cardiology in the Young , Volume 4 , Issue 3 , July 1994 , pp. 291 - 297
Copyright
Copyright © Cambridge University Press 1994

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