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Intramyocardial administration of autologous bone marrow mononuclear cells in a critically ill child with dilated cardiomyopathy

Published online by Cambridge University Press:  27 October 2010

Aris Lacis  and
Andrejs Erglis
Aris Lacis
Affiliation:
Latvian Centre of Pediatric Cardiology, Children’s Hospital, Riga, Latvia
Andrejs Erglis*
Affiliation:
Latvian Centre of Cardiology, Paula Stradina Clinical University Hospital, Riga, Latvia
*
Correspondence to: Prof. A. Erglis, MD, PhD, Latvian Centre of Cardiology, Pauls Stradins Clinical University Hospital, Pilsonu 13, LV-1002, Riga, Latvia. Tel: +371 67069379; Fax: +371 67069548; E-mail: a.a.erglis@stradini.lv
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Abstract

Almost half of the children with symptomatic dilated cardiomyopathy receive a transplant or die within 2 years; however, cardiac stem cell transplantation has become a promising therapeutic option. The present case demonstrates for the first time, to our knowledge, the intramyocardial administration of autologous bone marrow mononuclear cells in a critically ill 4-month-old child with severe dilated cardiomyopathy. Left ventricular ejection fraction increased from 20% before stem cell transplantation to 41% at 4 months of follow-up.

Keywords

Cardiac insufficiencystem cellstransplantation
Type
Brief Reports
Information
Cardiology in the Young , Volume 21 , Issue 1 , February 2011 , pp. 110 - 112
Copyright
Copyright © Cambridge University Press 2010

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