Hostname: page-component-cd9895bd7-hc48f Total loading time: 0 Render date: 2024-12-30T23:07:17.956Z Has data issue: false hasContentIssue false
  • English
  • Français

Muscular ventricular septal defect in a human embryo of 11 mm crown-rump length (six weeks)—no case of developmental arrest

Published online by Cambridge University Press:  19 August 2008

Arnold C. G. Wenink
Arnold C. G. Wenink*
Affiliation:
From the Department of Anatomy and Embryology, University of Leiden, Leiden
*
Dr. Arnold C. G. Wenink, Department of Anatomy and Embryology, PO Box 9602, 2300 RC Leiden, The Netherlands. Tel. 31-71-527-6682; Fax. 31-71-527-6680. .
Get access Rights & Permissions [Opens in a new window]

Abstract

A human embryo of 11 mm crown-rump length (six weeks, stage 15) is described, in which a muscular defect is present in the ventricular septum, in addition to the interventricular communication normal for this stage of development. The defect consists of large confluent spaces between very loose trabeculations. Its morphology is identical to that of the central muscular ventricular septal defect well recognized in the mature heart. It is suggested that the defect was caused by widening of the sinusoidal spaces which are temporarily present in the normal developing septum.

Keywords

Muscular ventricular septal defecttrabecular fusionembryo
Type
Brief Reports
Information
Cardiology in the Young , Volume 6 , Issue 2 , April 1996 , pp. 181 - 183
Copyright
Copyright © Cambridge University Press 1996

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

1.Wenink, ACG, Oppenheimer-Dekker, A, Moulaert, AJ. Muscular ventricular septal defects: a reappraisal of the anatomy. Am J Cardiol 1979; 43: 259–264.CrossRefGoogle ScholarPubMed
2.Anderson, RH, Macartney, FJ, Shinebourne, EA, Tynan, M. Paediatric Cardiology. Ventricular septal defect. Churchill Livingstone, Edinburgh, 1987.Google Scholar
3.Wenink, ACG. Embryology of the heart. In: Anderson, RH, Macartney, FJ, Shinebourne, EA, Tynan, M (eds). Paediatric Cardiology. Churchill Livingstone, Edinburgh, 1987, pp 83–108.Google Scholar
4.Wenink, ACG. Embryology of the ventricular septum. Sepa rate origin of its components. Virchows Arch Pathol Anat 1981; 390: 71–79.CrossRefGoogle Scholar
5.Wenink, ACG, Wisse, BJ, Groenendijk, PM. Development of the inlet portion of the right ventricle in the embryonic rat heart: the basis for tricuspid valve development. Anat Rec 1994; 239: 216–223.CrossRefGoogle ScholarPubMed
6.Lamers, WH, Wessels, A, Verbeek, FJ, Moorman, AFM, Virágh, Sz, Wenink, ACG, Gittenberger-de Groot, AC, Anderson, RH. New findings concerning ventricular septation in the human heart. Implications for maldevelopment. Circulation 1992; 86: 1194–1205.CrossRefGoogle ScholarPubMed
7.Harh, JY, Paul, MH. Experimental cardiac morphogenesis I. Development of the ventricular septum in the chick. Embryol Exp Morphol 1975; 33: 13–28.Google ScholarPubMed