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Pulmonary arterial thrombosis in a neonate with homozygous deficiency of antithrombin III: successful outcome following pulmonary thrombectomy and infusions of antithrombin III concentrate

Published online by Cambridge University Press:  19 August 2008

K. Roman ,
E. Rosenthal  and
R. Razavi
K. Roman*
Affiliation:
Department of Paediatric Cardiology, Guys Hospital, Guys and St. Thomas NHS Trust, London, UK
E. Rosenthal
Affiliation:
Department of Paediatric Cardiology, Guys Hospital, Guys and St. Thomas NHS Trust, London, UK
R. Razavi
Affiliation:
Department of Paediatric Cardiology, Guys Hospital, Guys and St. Thomas NHS Trust, London, UK
*
Dr Kevin Roman, MRCP, Specialist Registrar, Dept of Paediatric Cardiology, Southampton General Hospital, Tremona Road, Southampton SO16 6YD, UK. Tel: 01703 777222; Fax: 01703 794526; E-mail: roman@roman99.freeserve.co.uk
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Abstract

We report a newborn male who presented with severe central cyanosis on the third day of life. Partial thrombotic obstruction of the pulmonary trunk secondary to Antithrombin III (homozygous defect of heparin binding site) deficiency was subsequently diagnosed. Surgical thrombectomy, and infusions of Antithrombin III concentrate, led to a successful outcome. We postulate that intrauterine thrombosis occurred to give this unusual presentation.

Keywords

Antithrombin III deficiencyneonatal thrombosis
Type
Brief Reports
Information
Cardiology in the Young , Volume 10 , Issue 3 , May 2000 , pp. 275 - 278
Copyright
Copyright © Cambridge University Press 2000

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