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Subclinical rheumatic valvitis: a long-term follow-up

Published online by Cambridge University Press:  24 May 2005

Cristina Costa Duarte Lanna ,
Edward Tonelli ,
Marcio Vinicius Lins Barros ,
Eugenio Marcos Andrade Goulart  and
Cleonice Carvalho Coelho Mota
Cristina Costa Duarte Lanna
Affiliation:
Division of Paediatric Cardiology, Department of Paediatrics, Hospital das Clínicas, Federal University of Minas Gerais, Belo Horizonte, Brazil
Edward Tonelli
Affiliation:
Division of Paediatric Cardiology, Department of Paediatrics, Hospital das Clínicas, Federal University of Minas Gerais, Belo Horizonte, Brazil
Marcio Vinicius Lins Barros
Affiliation:
Division of Paediatric Cardiology, Department of Paediatrics, Hospital das Clínicas, Federal University of Minas Gerais, Belo Horizonte, Brazil
Eugenio Marcos Andrade Goulart
Affiliation:
Division of Paediatric Cardiology, Department of Paediatrics, Hospital das Clínicas, Federal University of Minas Gerais, Belo Horizonte, Brazil
Cleonice Carvalho Coelho Mota
Affiliation:
Division of Paediatric Cardiology, Department of Paediatrics, Hospital das Clínicas, Federal University of Minas Gerais, Belo Horizonte, Brazil
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Abstract

In order prospectively to investigate the frequency and evolution of subclinical valvitis, we selected 40 consecutive patients suffering their initial attack of rheumatic fever, seen in our clinic from 1992 to 1994, and followed-up until 2001, with a mean period of follow-up of 8.1 years, and a standard deviation of 0.6 year. We also assembled a matched control group of 37 healthy children and adolescents. We discovered a murmur of mitral regurgitation in 28 (70.0%) of the patients. In 3 (7.5%) of these patients, there was also a murmur of aortic regurgitation. In the group of 28 symptomatic patients, Doppler echocardiography showed mitral regurgitation in all, and aortic regurgitation in 17. In the group of 12 patients without clinical evidence of cardiac involvement, Doppler echocardiography identified mitral regurgitation in 2, isolated in one and associated with aortic regurgitation in the other. Thus, the frequency of subclinical valvitis was 16.7%. In patients with subclinical valvitis only the aortic regurgitation regressed during the period of follow-up. In the group of 28 symptomatic patients, mitral regurgitation disappeared in 6 (21.4%), aortic regurgitation in 7 of the 17 having this feature (41.2%), while 2 patients (7.1%) developed mitral stenosis. The sensitivity and specificity of cardiac auscultation were, respectively, 93.3%, with 95% confidence intervals between 72.3% and 97.4%, and 100%, with 95% confidence intervals between 65.5% and 100%, for the diagnosis of mitral regurgitation, and 16.7%, with 95% confidence intervals between 4.4% and 42.3%, and 100%, with 95% confidence intervals between 81.5% and 100%, for that of aortic regurgitation. We conclude that the Doppler echocardiogram is an important means of diagnosing and assessing the evolution of subclinical rheumatic valvar lesions, which are not always transient. We suggest that Doppler echocardiography should be performed in all patients with acute rheumatic fever. Subclinical valvitis should be considered as mild carditis, provided that strict criterions are observed in the differential diagnosis from physiological regurgitation, and Doppler echocardiographic findings are analyzed in the context of the other manifestations of the disease.

Keywords

Rheumatic feverDoppler echocardiogramsubclinical valvitis
Type
Original Article
Information
Cardiology in the Young , Volume 13 , Issue 5 , October 2003 , pp. 431 - 438
Copyright
© 2003 Cambridge University Press

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