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Three-dimensional speckle tracking echocardiography for early detection of left ventricular dysfunction in children with non-alcoholic fatty liver diseases

Published online by Cambridge University Press:  10 December 2020

Doaa El Amrousy Open the ORCID record for Doaa El Amrousy [Opens in a new window] ,
Esam Elgendy ,
Mohiee El-Deen Awad  and
Osama El Razaky
Doaa El Amrousy*
Affiliation:
Pediatric Department, Faculty of Medicine, Tanta University, Egypt
Esam Elgendy
Affiliation:
Pediatric Department, Faculty of Medicine, Tanta University, Egypt
Mohiee El-Deen Awad
Affiliation:
Pediatric Department, Faculty of Medicine, Tanta University, Egypt
Osama El Razaky
Affiliation:
Pediatric Department, Faculty of Medicine, Tanta University, Egypt
*
Author for correspondence: Prof. D. M. El Amrousy, Assistant Professor of Pediatrics, Faculty of Medicine, Tanta University, El Motasem street No 6. Tanta, Egypt. Tel: +201278155283; Fax: +20403280477. E-mail: doaamoha@yahoo.com
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Abstract

Objectives:

To detect early left ventricular dysfunction in children with non-alcoholic fatty liver disease using three-dimensional speckle tracking echocardiography.

Methods:

Forty obese children with non-alcoholic fatty liver disease were included as group I. Another 40 obese children without non-alcoholic fatty liver disease of matched age, sex, and weight were included as group II. Forty healthy controls of matched age and sex served as a control group. Anthropometric measurements, laboratory investigations, and echocardiographic examinations including three-dimensional speckle tracking echocardiography were measured for all included children.

Results:

Abnormal lipid profile was detected in children with non-alcoholic fatty liver disease. Troponin I levels were significantly higher in children with non-alcoholic fatty liver disease compared to obese children without non-alcoholic fatty liver disease and to healthy controls. Three-dimensional speckle tracking echocardiography examination revealed a significant reduction of left ventricular global longitudinal strain, circumferential strain, radial strain, and area strain in children with non-alcoholic fatty liver disease inspite of normal left ventricular fraction shortening measured by conventional echocardiography. All strains were negatively correlated with the grade of non-alcoholic fatty liver disease.

Conclusion:

Non-alcoholic fatty liver disease is associated with subclinical left ventricular dysfunction. Three-dimensional speckle tracking echocardiography can be helpful in identifying early left ventricular dysfunction in children with non-alcoholic fatty liver disease even in the presence of normal left ventricular ejection fraction.

Keywords

Non-alcoholic fatty liver disease3D-STEchildrencardiac strain
Type
Original Article
Information
Cardiology in the Young , Volume 31 , Issue 4 , April 2021 , pp. 562 - 567
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Copyright
© The Author(s), 2020. Published by Cambridge University Press

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