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First experience with a new drug-eluting balloon for the treatment of congenital pulmonary vein stenosis in a neonate

Published online by Cambridge University Press:  02 June 2010

Goetz Christoph Mueller ,
Ali Dodge-Khatami  and
Jochen Weil
Goetz Christoph Mueller*
Affiliation:
Department of Paediatric Cardiology, University Heart Center Hamburg, Hamburg, Germany
Ali Dodge-Khatami
Affiliation:
Department of Congenital Cardiac Surgery, University Heart Center Hamburg, Hamburg, Germany
Jochen Weil
Affiliation:
Department of Paediatric Cardiology, University Heart Center Hamburg, Hamburg, Germany
*
Correspondence to: G. C. Mueller, MD, Department of Paediatric Cardiology, University Heart Center Hamburg-Eppendorf, Martinistraße 52, 20246, Hamburg/Germany. Tel: +49 (0)40 7410-53718; Fax: +49 (0)40 7410-53730; E-mail: go.mueller@uke.uni-hamburg.de
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Abstract

Paclitaxel-eluting balloons are a new and innovative method in the treatment of in-stent stenosis and small vessel disease in adult cardiac pathology. The treatment of congenital pulmonary vein stenosis is difficult to manage, and results in a high mortality rate due to residual or recurrent stenosis. We report the first case of treatment for neonatal pulmonary vein restenosis with a paclitaxel-eluting balloon.

Keywords

Pulmonary vein stenosisdrug-eluting balloonpaclitaxelcongenital cardiac diseaseintervention
Type
Brief Reports
Information
Cardiology in the Young , Volume 20 , Issue 4 , August 2010 , pp. 455 - 458
Copyright
Copyright © Cambridge University Press 2010

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References

1. Latson, LA, Prieto, LR. Congenital and acquired pulmonary vein stenosis. Circulation 2007; 115: 103–108.CrossRefGoogle ScholarPubMed
2. Breinholt, JP, Hawkins, JA, Minich, LA, et al. . Pulmonary vein stenosis with normal connection: associated cardiac abnormalities and variable outcome. Ann Thorac Surg 1999; 68: 164–168.CrossRefGoogle ScholarPubMed
3. Driscoll, DJ, Hesslein, PS, Mullins, CE. Congenital stenosis of individual pulmonary veins: clinical spectrum and unsuccessful treatment by transvenous balloon dilation. Am J Cardiol 1982; 49: 1767–1772.CrossRefGoogle ScholarPubMed
4. Seale, AN, Daubeney, PE, Magee, AG, Rigby, ML. Pulmonary vein stenosis: initial experience with cutting balloon angioplasty. Heart 2006; 92: 815–820.CrossRefGoogle ScholarPubMed
5. Tomita, H, Watanabe, K, Yazaki, S, et al. . Stent implantation and subsequent dilatation for pulmonary vein stenosis in pediatric patients: maximizing effectiveness. Circ J 2003; 67: 187–190.CrossRefGoogle ScholarPubMed
6. Herdeg, C, Oberhoff, M, Baumbach, A, et al. . Local paclitaxel delivery for the prevention of restenosis: biological effects and efficacy in vivo. J Am Coll Cardiol 2000; 35: 1969–1976.CrossRefGoogle ScholarPubMed
7. Scheller, B, Speck, U, Bohm, M. Prevention of restenosis: is angioplasty the answer? Heart 2007; 93: 539–541.CrossRefGoogle ScholarPubMed
8. Scheller, B, Speck, U, Romeike, B, et al. . Contrast media as carriers for local drug delivery. Successful inhibition of neointimal proliferation in the porcine coronary stent model. Eur Heart J 2003; 24: 1462–1467.CrossRefGoogle ScholarPubMed
9. Huizing, MT, Keung, AC, Rosing, H, et al. . Pharmacokinetics of paclitaxel and metabolites in a randomized comparative study in platinum-pretreated ovarian cancer patients. J Clin Oncol 1993; 11: 2127–2135.CrossRefGoogle Scholar
10. Sadr, IM, Tan, PE, Kieran, MW, Jenkins, KJ. Mechanism of pulmonary vein stenosis in infants with normally connected veins. Am J Cardiol 2000; 86: 577–579.CrossRefGoogle ScholarPubMed