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Formulation and release kinetics of ibuprofen–bentonite tablets

Published online by Cambridge University Press:  29 November 2022

Jamal Alyoussef Alkrad Open the ORCID record for Jamal Alyoussef Alkrad [Opens in a new window] ,
Sind Al-Sammarraie ,
Eman Zmaily Dahmash Open the ORCID record for Eman Zmaily Dahmash [Opens in a new window] ,
Nidal A. Qinna  and
Abdallah Y. Naser
Jamal Alyoussef Alkrad*
Affiliation:
Faculty of Pharmacy, Department of Applied Pharmaceutical Sciences and Clinical Pharmacy, Isra University, PO Boxes 22 and 23, Amman, Jordan
Sind Al-Sammarraie
Affiliation:
Faculty of Pharmacy, Department of Applied Pharmaceutical Sciences and Clinical Pharmacy, Isra University, PO Boxes 22 and 23, Amman, Jordan
Eman Zmaily Dahmash
Affiliation:
School of Life Sciences, Pharmacy and Chemistry, Department of Chemical and Pharmaceutical Sciences, Kingston University, Surrey KT1 2EE, UK
Nidal A. Qinna
Affiliation:
University of Petra Pharmaceutical Center (UPPC), Faculty of Pharmacy and Medical Sciences, University of Petra, PO Box 961344, Amman 11196, Jordan
Abdallah Y. Naser
Affiliation:
Faculty of Pharmacy, Department of Applied Pharmaceutical Sciences and Clinical Pharmacy, Isra University, PO Boxes 22 and 23, Amman, Jordan
*
*Email: jamal.alkrad@iu.edu.jo
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Abstract

Bentonite-based tablets offer multiple advantages over other types of formulated tablets, including being biocompatible and cost-effective, and they can be used to develop gel-like matrices that have potential for use in sustained-release formulations. Developing a high-load sustained-release formulation has been reported to be challenging; therefore, the aim of this study was to develop systematically bentonite-based sustained-release tablets for a high-load active agent (ibuprofen) and investigate their release kinetics. Ibuprofen-loaded tablets (800 mg) were prepared using wet and dry granulation followed by enteric coating of the tablets. Fourier-transform infrared spectroscopy, differential scanning calorimetry and X-ray powder diffraction were used to evaluate the compatibility of ibuprofen with bentonite. The results show that these tablets comply with compendial requirements. In addition, the release profile of the formulations reveals that the drug follows a non-Fickian release model. The present formulation demonstrates a new use of bentonite as a safe and cost-effective excipient with adequate binding and compaction for preparing sustained-release tablets.

Keywords

bentonitebindergranulationibuprofensustained releasetablets
Type
Article
Information
Clay Minerals , Volume 57 , Issue 3-4 , September 2022 , pp. 172 - 182
Copyright
Copyright © The Author(s), 2022. Published by Cambridge University Press on behalf of The Mineralogical Society of Great Britain and Ireland

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Footnotes

Accepted Manuscript online: 29 November 2022; Associate editor: Zhou Chun-Hui

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