Hostname: page-component-cd9895bd7-8ctnn Total loading time: 0 Render date: 2024-12-23T07:34:41.208Z Has data issue: false hasContentIssue false
  • English
  • Français

Polysaccharide-halloysite nanotube composites for biomedical applications: a review

Published online by Cambridge University Press:  02 January 2018

Mingxian Liu ,
Rui He ,
Jing Yang ,
Zheru Long ,
Biao Huang ,
Yongwang Liu  and
Changren Zhou
Mingxian Liu*
Affiliation:
Department of Materials Science and Engineering, Jinan University, Guangzhou 510632, China
Rui He
Affiliation:
Department of Materials Science and Engineering, Jinan University, Guangzhou 510632, China
Jing Yang
Affiliation:
Department of Materials Science and Engineering, Jinan University, Guangzhou 510632, China
Zheru Long
Affiliation:
Department of Materials Science and Engineering, Jinan University, Guangzhou 510632, China
Biao Huang
Affiliation:
Department of Materials Science and Engineering, Jinan University, Guangzhou 510632, China
Yongwang Liu
Affiliation:
Department of Materials Science and Engineering, Jinan University, Guangzhou 510632, China
Changren Zhou*
Affiliation:
Department of Materials Science and Engineering, Jinan University, Guangzhou 510632, China
*
*E-mail: liumx@jnu.edu.cn (M.L.) and tcrz9@jnu.edu.cn (C.Z.)
*E-mail: liumx@jnu.edu.cn (M.L.) and tcrz9@jnu.edu.cn (C.Z.)
Get access Rights & Permissions [Opens in a new window]

Abstract

As a unique tubular nanoclay, halloysite nanotubes (HNTs) have recently attracted significant research attention. The HNTs have outer diameters of ∼50 nm, inner lumens of ∼20 nm and are 200–1000 nm long. They are biocompatible nanomaterials and widely available in nature, which makes them good candidates for application in biomedicine. Compared with other types of nanoparticles such as polymer nanoparticles and carbon nanotubes, the drawbacks associated with HNTs include brittleness, difficulty with fabrication, low fracture strength, high density and inadequate biocompatibility. Preparation of polysaccharide-HNT composites offer a means to overcome these shortcomings. Halloysite nanotubes can be incorporated easily into polysaccharides via solution mixing, such as with chitosan (CS), sodium alginate, cellulose, pectin and amylose, for forming composite films, porous scaffolds or hydrogels. The interfacial interactions, such as electrostatic attraction and hydrogen bonding, between HNTs and the polysaccharides are critical for improvement of the properties. Morphology results show that HNTs are dispersed uniformly in the composites. The mechanical strength and Young's modulus of the composites in both the dry and wet states are enhanced by HNTs and the HNTs can also increase the storage modulus, glass-transition temperature and thermal stability of the composites. Cytocompatibility results demonstrate that the polysaccharide-HNT composites have low cytotoxicity even for HNT loading >80%. Therefore, the polysaccharide-HNT composites show great potential for biomedical applications, e.g. as tissue engineering scaffold materials, wound-dressing materials, drug-delivery carriers, and cell-isolation surfaces.

Keywords

halloysitechitosanalginateinterfacial interactionscytocompatibilitymechanical properties
Type
Research Article
Information
Clay Minerals , Volume 51 , Issue 3 , June 2016 , pp. 457 - 467
Copyright
Copyright © The Mineralogical Society of Great Britain and Ireland 2016

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Brindley, G., Robinson, K. & MacEwan, D. (1946)Theclay minerals halloysite and meta-halloysite. Nature, 157, 225–226.Google Scholar
Cavallaro, G., Gianguzza, A., Lazzara, G., Milioto, S. & Piazzese, D. (2013) Alginate gel beads filled with halloysite nanotubes. Applied Clay Science, 72, 132–137.10.1016/j.clay.2012.12.001Google Scholar
Chang, P.R., Xie, Y., Wu, D. & Ma, X. (2011) Amylose wrapped halloysite nanotubes. Carbohydrate Polymers, 84, 1426–1429.Google Scholar
De Silva, R., Pasbakhsh, P., Goh, K.-L., Chai, S.-P. & Ismail, H. (2013) Physico-chemical characterisation of chitosan/ halloysite composite membranes. Polymer Testing, 32, 265–271.Google Scholar
Dzamukova, M.R., Naumenko, E.A., Lvov, Y.M. & Fakhrullin, R.F. (2015) Enzyme-activated intracellular drug delivery with tubule clay nanoformulation. Scientific Reports, 5.Google Scholar
Fakhrullina, G.I., Akhatova, F.S., Lvov, Y.M. & Fakhrullin, R.F. (2015) Toxicity of halloysite clay nanotubes in vivo: A caenorhabditis elegans study. Environmental Science: Nano, 2, 54–59.Google Scholar
Fan, L., Zhang, J. & Wang, A. (2013) In situ generation of sodium alginate/hydroxyapatite/halloysite nanotubes nanocomposite hydrogel beads as drug-controlled release matrices. Journal of Materials Chemistry B, 1, 6261–6270.10.1039/c3tb20971gGoogle Scholar
Hughes, A.D. & King, M.R. (2010) Use of naturally occurring halloysite nanotubes for enhanced capture of flowing cells. Langmuir, 26, 12155–12164.Google Scholar
Joussein, E., Petit, S., Churchman, J., Theng, B., Righi, D. & Delvaux, B. (2005) Halloysite clay minerals — a review. Clay Minerals, 40, 383–426.10.1180/0009855054040180CrossRefGoogle Scholar
Levis, S. & Deasy, P. (2003) Use of coated microtubular halloysite for the sustained release of diltiazem hydrochloride and propranolol hydrochloride. International Journal of Pharmaceutics, 253, 145–157.10.1016/S0378-5173(02)00702-0CrossRefGoogle ScholarPubMed
Liu, M., Guo, B., Du, M. & Jia, D. (2007) Drying induced aggregation of halloysite nanotubes in polyvinyl alcohol/ halloysite nanotubes solution and its effect on properties of composite film. Applied Physics A, 88, 391–395.10.1007/s00339-007-3995-8Google Scholar
Liu, L., Wan, Y., Xie, Y., Zhai, R., Zhang, B. & Liu, J. (2012a) The removal of dye from aqueous solution using alginate-halloysite nanotube beads. Chemical Engineering Journal, 187, 210–216.10.1016/j.cej.2012.01.136CrossRefGoogle Scholar
Liu, M., Zhang, Y., Wu, C., Xiong, S. & Zhou, C. (2012b) Chitosan/halloysite nanotubes bionanocomposites: Structure, mechanical properties and biocompatibility. International Journal of Biological Macromolecules, 51, 566–575.10.1016/j.ijbiomac.2012.06.022Google Scholar
Liu, M., Wu, C., Jiao, Y., Xiong, S. & Zhou, C. (2013a) Chitosan-halloysite nanotubes nanocomposite scaffolds for tissue engineering. Journal of Materials Chemistry B, 1, 2078–2089.10.1039/c3tb20084aCrossRefGoogle ScholarPubMed
Liu, M., Zhang, Y. & Zhou, C. (2013b) Nanocomposites of halloysite and polylactide. Applied Clay Science, 75, 52–59.Google Scholar
Liu, M., Jia, Z., Jia, D. & Zhou, C. (2014a) Recent advance in research on halloysite nanotubes-polymer nanocomposite. Progress in Polymer Science, 39, 1498–1525.Google Scholar
Liu, M., Shen, Y., Ao, P., Dai, L., Liu, Z. & Zhou, C. (2014b) The improvement of hemo static and wound healing property of chitosan by halloysite nanotubes. RSC Advances, 4, 23540–23553.Google Scholar
Liu, M., Dai, L., Shi, H., Xiong, S. & Zhou, C. (2015) In vitro evaluation of alginate/halloysite nanotube composite scaffolds for tissue engineering. Materials Science and Engineering: C, 49, 700–712.Google Scholar
Luo, Z., Wang, A., Wang, C., Qin, W., Zhao, N., Song, H. & Gao, J. (2014) Liquid crystalline phase behavior and fiber spinning of cellulose/ionic liquid/halloysite nanotubes dispersions. Journal of Materials Chemistry A, 2, 7327–7336.10.1039/c4ta00225cCrossRefGoogle Scholar
Lvov, Y., Price, R., Gaber, B. & Ichinose, I. (2002) Thin film nano fabrication via layer-by-layer adsorption of tubule halloysite, spherical silica, proteins and polycations. Colloids and Surfaces A: Physicochemical and Engineering Aspects, 198, 375–382.10.1016/S0927-7757(01)00970-0CrossRefGoogle Scholar
Lvov, Y. & Abdullayev, E. (2013) Functional polymer-clay nanotube composites with sustained release of chemical agents. Progress in Polymer Science, 38, 1690–1719.Google Scholar
Lvov, Y., Wang, W., Zhang, L. & Fakhrullin R (2016) Halloysite clay nanotubes for loading and sustained release of functional compounds. Advanced Materials, 28, 1227–1250.10.1002/adma.201502341Google Scholar
Mitchell, M.J., Castellanos, C.A. & King, M.R. (2015) Surfactant functionalization induces robust, differential adhesion of tumor cells and blood cells to charged nanotube-coated biomaterials under flow. Biomaterials, 56, 179–186.10.1016/j.biomaterials.2015.03.045Google Scholar
Peng, Q., Liu, M., Zheng, J. & Zhou, C. (2015) Adsorption of dyes in aqueous solutions by chitosan—halloysite nanotubes composite hydrogel beads. Microporous and Mesoporous Materials, 201, 190–201.10.1016/j.micromeso.2014.09.003CrossRefGoogle Scholar
Qi, R., Guo, R., Shen, M., Cao, X., Zhang, L., Xu, J., Yu, J. & Shi, X. (2010) Electrospun poly(lactic-co-glycolic acid)/halloysite nanotube composite nanofibers for drug encapsulation and sustained release. Journal of Materials Chemistry, 20, 10622–10629.10.1039/c0jm01328eGoogle Scholar
Schmitt, H., Prashantha, K., Soulestin, J., Lacrampe, M. & Krawczak, P. (2012) Preparation and properties of novel melt-blended halloysite nanotubes/wheat starch nanocomposites. Carbohydrate Polymers, 89, 920–927.10.1016/j.carbpol.2012.04.037Google Scholar
Soheilmoghaddam, M. & Wahit, M.U. (2013) Development of regenerated cellulose/halloysite nanotube bionano-composite films with ionic liquid. International Journal of Biological Macromolecules, 58, 133–139.Google Scholar
Soheilmoghaddam, M., Wahit, M.U., Mahmoudian, S. & Hanid, N.A. (2013) Regenerated cellulose/halloysite nanotube nanocomposite films prepared with an ionic liquid. Materials Chemistry and Physics, 141, 936–943.10.1016/j.matchemphys.2013.06.029CrossRefGoogle Scholar
Sun, X., Zhang, Y., Shen, H. & Jia, N. (2010) Direct electrochemistry and electrocatalysis of horseradish peroxidase based on halloysite nanotubes/chitosan nanocomposite film. Electrochimica Acta, 56, 700–705.Google Scholar
Sweetman, L.J., Moulton, S.E. & Wallace, G.G. (2008) Characterisation of porous freeze dried conducting carbon nanotube-chitosan scaffolds. Journal of Materials Chemistry, 18, 5417–5422.Google Scholar
Tarì, G., Bobos, I., Gomes, C.S. & Ferreira, J.M. (1999) Modification of surface charge properties during kaolinite to halloysite-7 transformation. Journal of Colloid and Interface Science, 210, 360–366.CrossRefGoogle ScholarPubMed
Thein-Han, W.W. & Misra, R.D.K. (2009) Biomimetic chitosan-nanohydroxyapatite composite scaffolds for bone tissue engineering. Acta Biomaterialia, 5, 1182–1197.10.1016/j.actbio.2008.11.025CrossRefGoogle ScholarPubMed
Vergaro, V., Abdullayev, E., Lvov, Y.M., Zeitoun, A., Cingolani, R., Rinaldi, R. & Leporatti, S. (2010) Cytocompatibility and uptake of halloysite clay nanotubes. Biomacromolecules, 11, 820–826.10.1021/bm9014446Google Scholar
Xue, J., Niu, Y., Gong, M., Shi, R., Chen, D., Zhang, L. & Lvov, Y. (2015) Electrospun microfiber membranes embedded with drug-loaded clay nanotubes for sustained antimicrobial protection. ACS Nano, 9, 1600–1612.Google Scholar
Yah, W.O., Takahara, A. & Lvov, Y.M. (2012) Selective modification of halloysite lumen with octadecylpho-sphonic acid: New inorganic tubular micelle. Journal of the American Chemical Society, 134, 1853–1859.10.1021/ja210258yGoogle Scholar
Zhai, R., Zhang, B., Wan, Y., Li, C., Wang, J. & Liu, J. (2013) Chitosan-halloysite hybrid-nanotubes: Horseradish peroxidase immobilization and applications in phenol removal. Chemical Engineering Journal, 214, 304–309.10.1016/j.cej.2012.10.073Google Scholar
Zheng, Y. & Wang, A. (2009) Enhanced adsorption of ammonium using hydrogel composites based on chitosan and halloysite. Journal of Macromolecular Science, Part A, 47, 33–38.10.1080/10601320903394421Google Scholar