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Emotional Regulation: Implications for the Psychobiology of Psychotherapy

Published online by Cambridge University Press:  07 November 2014

Dan J. Stein
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Abstract

A range of studies have contributed to understanding the psychobiology of emotional regulation. Functional imaging studies have demonstrated that cortico-limbic circuitry plays an important role in mediating processes such as reappraisal and suppression. Dorsolateral prefrontal cortex may be important in conscious reframing, while ventromedial prefrontal cortex and orbitofrontal cortex may be particularly important in emotion evaluation. Gene variants and early environments impact underlying emotional regulation and its neurobiology. It may be hypothesized that during interventions such as psychotherapy there are improvements in emotional regulation, together with the normalization of related psycho-biological mechanisms.

Type
Pearls in Clinical Neuroscience
Information
CNS Spectrums , Volume 13 , Issue 3 , March 2008 , pp. 195 - 201
Copyright
Copyright © Cambridge University Press 2008

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References

REFERENCES

1.Davidson, RJ, Putnam, KM, CL, Larson. Dysfunction in the neural circuitry of emotion regulation-a possible prelude to violence. Science. 2000;289:591–594.CrossRefGoogle ScholarPubMed
2.Chambers, RA, Taylor, JR, Potenza, MN. Developmental neurocircuitry of motivation in adolescence: A critical period of addiction vulnerability. Am J Psychiatry. 2003;160:1041–1052.Google Scholar
3.Goldstein, RZ, Volkow, ND. Drug addiction and its underlying neurobiological basis: neuroimaging evidence for the involvement of the frontal cortex. Am J Psychiatry. 2002;159:1642–1652.CrossRefGoogle ScholarPubMed
4.Stein, DJ, Moeller, FG. The man who turned bad. CNS Spectr. 2005;10:88–90.Google Scholar
5.Beauregard, M, Levesque, J, Bourgouin, P. Neural correlates of conscious self-regulation of emotion. J Neurosci. 2001;21:RC165.Google Scholar
6.Ochsner, KN, Bunge, SA, Gross, JJ, et al.Rethinking feelings: an FMRI study of the cognitive regulation of emotion. J Cogn Neurosci. 2002;14:1215–1229.CrossRefGoogle ScholarPubMed
7.Ochsner, KN, Ray, RD, Cooper, JC, et al.For better or for worse: neural systems supporting the cognitive down- and up-regulation of negative emotion. Neuroimage. 2004;23:483–499.Google Scholar
8.Schaefer, SM, Jackson, DC, Davidson, RJ, et al.Modulation of amygdalar activity by the conscious regulation of negative emotion. J Cogn Neurosci. 2002;14:913–921.Google Scholar
9.Levesgue, J, Joanette, Y, Mensour, B, et al.Neural basis of emotional self-regulation in childhood. Neuroscience. 2004;129:361–369.Google Scholar
10.Levesque, J, Eugene, F, Joanette, Y, et al.Neural circuitry underlying voluntary suppression of sadness. Biol Psychiatry. 2003:53:502–510.CrossRefGoogle ScholarPubMed
11.Ohira, H, Nomura, M, Ichikawa, N, et al.Association of neural and physiological responses during voluntary emotion suppression. Neuroimage. 2006;29:721–733.Google Scholar
12.Phan, KL, Fitzgerald, DA, Nathan, PJ, et al.Neural substrates for voluntary suppression of negative affect: a functional magnetic resonance imaging study. Biol Psychiatry. 2005;57:210–219.Google Scholar
13.Herwig, U, Baumgartner, T, Kaffenberger, T, et al.Modulation of anticipatory emotion and perception processing by cognitive control. Neuroimage. 2007;37:652–662.Google Scholar
14.Kalisch, R, Wiech, K, Critchley, HD, et al.Levels of appraisal: a medial prefrontal role in high-level appraisal of emotional material. Neuroimage. 2006;30:1458–1466.Google Scholar
15.Kim, SH, Hamann, S. Neural correlates of positive and negative emotion regulation. J Cogn Neurosci. 2007;19:776–798.CrossRefGoogle ScholarPubMed
16.Hariri, AR, Mattay, VS, Tessitore, A, et al.Neocortical modulation of the amygdala response to fearful stimuli. Biol Psychiatry. 2003;53:494–501.Google Scholar
17.Eippert, FVeit, R, Weiskopf, N, et al.Regulation of emotional responses elicited by threat-related stimuli. Hum Brain Mapp. 2007;28:409–423.Google Scholar
18.Blair, KS, Smith, BW, Mitchell, DGV, et al.Modulation of emotion by cognition and cognition by emotion. Neuroimage. 2007;35:430–440.Google Scholar
19.Ochsner, KN, Gross, JJ. The cognitive control of emotion. Trends Cogn Sci. 2005;9:242–249.Google Scholar
20.Cooney, RE, Joormann, J, Atlas, LY, et al.Remembering the good times: neural correlates of affect regulation. Neuroreport. 2007;18:1771–1774.CrossRefGoogle ScholarPubMed
21.Goldin, PR, McRae, K, Ramef, W, Gross, JJ. The neural bases of emotion regulation: reappraisal and suppression of negative emotion. Biol Psychiatry. 2007; 09 20 [Epub ahead of print.]Google Scholar
22.Kalisch, R, Wiech, K, Herrmann, K, Dolan, RJ. Neural correlates of self-distraction from anxiety and a process model of cognitive emotion regulation. J Cogn Neurosci. 2006;18:1266–1276.Google Scholar
23.Rauch, AV, Ohrmann, P, Bauer, J, et al.Cognitive coping style modulates neural responses to emotional faces in healthy humans: a 3-T FMRI study. Cereb Cortex. 2007;17:2526–2535.Google Scholar
24.Gillath, O, Bunge, SA, Shaver, PR, Wendelken, C, Mikulincer, M. Attachment-style differences in the ability to suppress negative thoughts: exploring the neural correlates. Neuroimage. 2005;28:835–847.Google Scholar
25.Ray, RD, Ochsner, KN, Cooper, JC, et al.Individual differences in trait rumination and the neural systems supporting cognitive reappraisal. Cogn Affect Behav Neurosci. 2005;5:156–168.Google Scholar
26.Kalin, NH, Shelton, SE, Fox, AS, Oakes, TR, Davidson, RJ. Brain regions associated with the expression and contextual regulation of anxiety in primates. Biol Psychiatry. 2005;58:796–804.CrossRefGoogle ScholarPubMed
27.Hariri, AR, Holmes, A. Genetics of emotional regulation: the role of the serotonin transporter in neural function. Trends Cogn Sci. 2006;10:182–191.Google Scholar
28.Stein, DJ, Hemmings, S, Moolman-Smook, H, Audenaert, K. 5-HT2A: its role in frontally mediated executive function and related psychopathology. CNS Spectr. 2007;12:512–516.Google Scholar
29.Denollet, J, Nyklicek, I, Vingerhoets, A. Emotion, Emotional Regulation, and Health. New York, NY: Springer; 2007.Google Scholar
30.Gross, JJ. Emotion regulation: affective, cognitive, and social consequences. Psychophysiology. 2002;39:281–291.Google Scholar
31.Urry, HL, van Reekum, CM, Johnstone, T, et al.Amygdala and ventromedial prefrontal cortex are inversely coupled during regulation of negative affect and predict the diurnal pattern of Cortisol secretion among older adults. J Neurosci. 2006;26:4415–4425.Google Scholar
32.Yang, RJ, Mozhui, K, Karlsson, RM, et al.Variation in mouse basolateral amygdala volume is associated with differences in stress reactivity and fear learning. Neuropsychopharmacoiogy. 2008; 01 9 [Epub ahead of print.]Google Scholar
33.Drabant, EM, Hariri, AR, Meyer-Lindenberg, A, et al.Catechol O-methyltransferase val 158met genotype and neural mechanisms related to affective arousal and regulation. Arch Gen Psychiatry. 2006;63:1396–1406.CrossRefGoogle Scholar
34.Taylor, SE, Eisenberger, NI, Saxbe, D, Lehman, BJ, Lieberman, MD. Neural responses to emotional stimuli are associated with childhood family stress. Biol Psychiatry. 2006;60:296–301.Google Scholar
35.Higley, JD, Mehlman, PT, Taub, DM, et al.Excessive mortality in young free-ranging male non-human primates with low cerebrospinal fluid 5-hydroxyindolacetic acid concentrations. Arch Gen Psychiatry. 1996;53:537–543.Google Scholar
36.Baron-Cohen, S, Knickmeyer, RC, Belmonte, MK. Sex differences in the brain: implications for explaining autism. Science. 2005;310:819–823.Google Scholar
37.Taylor, SF, Liberzon, I. Neural correlates of emotion regulation in psychopathology. Trends Cogn Sci. 2007;11:413–418.Google Scholar
38.Gross, JJ, John, OP. Individual differences in two emotion regulation processes: implications for affect, relationships, and well-being. J Pers Soc Psychol. 2003;85:348–362.Google Scholar
39.Andrews, G, Singh, M, Bond, M. The defense style questionnaire. J Nerv Ment Dis. 1993;181:246–256.Google Scholar
40.Lumley, MA, Neely, LC, Burger, AJ. The assessment of alexithymia in medical settings: implications for understanding and treating health problems. J Pers Assess. 2007;89:230–246.Google Scholar
41.Linehan, MM. Cognitive-Behavioral Treatment of Borderline Personality Disorder. New York, NY: Guilford Press; 1993.Google Scholar
42.Roffman, JL, Marci, CD, Glick, DM, Dougherty, DD, Rauch, SL. Neuroimaging and the functional neuroanatomy of psychotherapy. Psychol Med. 2005;35:1385–1398.Google Scholar
43.Linden, DE. How psychotherapy changes the brain-the contribution of functional neuroimaging. Mol Psychiatry. 2006;11:528–538.Google Scholar
44.Etkin, A, Pittenger, C, Polan, HJ, Kandel, ER. Toward a neurobiology of psychotherapy: basic science and clinical applications. J Neuropsychiatry Clin Neurosci. 2005;17:145–158.Google Scholar
45.Critchley, HD. Neural mechanisms of autonomic, affective, and cognitive integration. J Comp Neurol. 2005;493:154–166.Google Scholar