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Mind and Muscle: The Cognitive-Affective Neuroscience of Exercise

Published online by Cambridge University Press:  07 November 2014

Abstract

There is growing basic-science interest in the mechanisms underpinning the positive effects of exercise on brain function and cognitive-affective performance. There is also increasing clinical evidence that exercise may prevent and treat various neuropsychiatric disorders. At the same time, there is growing awareness that athletic performance is mediated in crucial ways by central nervous system mechanisms. The relevant mechanisms in all these cases requires further exploration, but likely includes neurotrophic, neuroendocrine, and neurotransmitter systems, which in turn are crucial mediators of psychopathology and resilience. The hypothesis that Homo sapiens evolved as a specialist endurance runner provides an intriguing context against which to research the proximal mechanisms relevant to a cognitive-affective neuroscience of exercise.

Type
Pearls in Clinical Neuroscience
Copyright
Copyright © Cambridge University Press 2007

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References

REFERENCES

1.van Praag, H, Christie, BR, Sejnowski, TJ, Gage, FH. Running enhances neurogenesis, learning, and long-term potentiation in mice. Proc Natl Acad Sci U S A. 1999;96:1342713431.CrossRefGoogle ScholarPubMed
2.Vaynman, S, Gomez-Pinilla, F. Revenge of the “sit”: how lifestyle impacts neuronal and cognitive health through molecular systems that interface energy metabolism with neuronal plasticity. J Neurosci Res. 2006;84:699715.CrossRefGoogle ScholarPubMed
3.Mastorakos, G, Pavlatou, M, Diamanti-Kandarakis, E, Chrousos, GP. Exercise and the stress system. Hormones (Athens). 2005;4:7389.Google ScholarPubMed
4.Kiraly, MA, Kiraly, SJ. The effect of exercise on hippocampal integrity: review of recent research. Int J Psychiatry Med. 2005;35:7589.CrossRefGoogle ScholarPubMed
5.Smith, AD, Zigmond, MJ. Can the brain be protected through exercise? Lessons from an animal model of parkinsonism. Exp Neurol. 2003;184:3139.CrossRefGoogle ScholarPubMed
6.Ernst, C, Olson, AK, Pinel, JPJ, Lam, RW, Christie, BR. Antidepressant effects of exercise: evidence for an adult-neurogenesis hypothesis? J Psychiatry Neurosci. 2006;31:8492.Google ScholarPubMed
7.Dishman, RK, Berthoud, HR, Booth, FW, et al. Neurobiology of exercise. Obesity (Silver Spring). 2006;14:345356.CrossRefGoogle ScholarPubMed
8.Duman, RS. Neurotrophic factors and regulation of mood: role of exercise, diet and metabolism. Neurobiol Aging. 2005;(26 suppl 1):8893.CrossRefGoogle ScholarPubMed
9.Williamson, JW, McColl, R, Mathews, D. Evidence for central command activation of the human insular cortex during exercise. J Appl Physiol. 2003;94:17261734.CrossRefGoogle ScholarPubMed
10.Kemppainen, J, Aalto, S, Fujimoto, T, et al. High intensity exercise decreases global brain glucose uptake in humans. J Physiol. 2005;568(pt 1):323332.CrossRefGoogle ScholarPubMed
11.Benwell, NM, Mastaglia, FL, Thickbroom, GW. Reduced functional activation after fatiguing exercise is not confined to primary motor areas. Exp Brain Res. 2006;175:575583.CrossRefGoogle Scholar
12.Kramer, AF, Erickson, KI, Colcombe, SJ. Exercise, cognition, and the aging brain. J Appl Physiol. 2006;101:12371242.CrossRefGoogle ScholarPubMed
13.Colcombe, SJ, Kramer, AF, Erickson, KI, et al. Cardiovascular fitness, cortical plasticity, and aging. Proc Natl Acad Sci U S A. 2004;101:33163321.CrossRefGoogle ScholarPubMed
14.Broocks, A, Meyer, T, George, A, et al. Decreased neuroendocrine responses to metachlorophenylpiperazine (m-CPP) but normal responses to ipsapirone in marathon runners. Neuropsychopharmacology. 1999;20:150161.CrossRefGoogle ScholarPubMed
15.Noakes, TD, Clair Gibson, A, Lambert, EV. From catastrophe to complexity: a novel model of integrative central neural regulation of effort and fatigue during exercise in humans: summary and conclusions. Br J Sports Med. 2005;39:120124.CrossRefGoogle ScholarPubMed
16.Nybo, L, Secher, NH. Cerebral perturbations provoked by prolonged exercise. Prog Neurobiol. 2004; 72:223261.CrossRefGoogle ScholarPubMed
17.Gandevia, SC. Spinal and supraspinal factors in human muscle fatigue. Physiol Rev. 2001;81:17251789.CrossRefGoogle ScholarPubMed
18.St Clair Gibson, A, Lambert, EV, Rauch, LH, et al. The role of information processing between the brain and peripheral physiological systems in pacing and perception of effort. Sports Med. 2006;36:705722.CrossRefGoogle ScholarPubMed
19.Dalsgaard, MK. Fuelling cerebral activity in exercising man. J Cereb Blood Flow Metab. 2006;6:731750.CrossRefGoogle Scholar
20.Noakes, TD. The limits of endurance exercise. Basic Res Cardiol. 2006;101:408417.CrossRefGoogle ScholarPubMed
21.Nowak, M, Holm, S, Biering-Sorensen, F, Secher, NH, Friberg, L. “Central command” and insular activation during attempted foot lifting in paraplegic humans. Hum Brain Mapp. 2005;25:259265.CrossRefGoogle ScholarPubMed
22.Green, AL, Wang, S, Purvis, S, et al. Identifying cardiorespiratory neurocircuitry involved in central command during exercise in humans. J Physiol. 2006 Nov 2; [Epub ahead of print].Google ScholarPubMed
23.Williamson, JW, Fadel, PJ, Mitchell, JH. New insights into central cardiovascular control during exercise in humans: a central command update. Exp Physiol. 2006;91:5158.CrossRefGoogle ScholarPubMed
24.Podewils, LJ, Guallar, E, Kuller, LH, et al. Physical activity, APOE genotype, and dementia risk: findings from the Cardiovascular Health Cognition Study. Am J Epidemiol. 2005;161:639651.CrossRefGoogle ScholarPubMed
25.Larson, EB, Wang, L, Bowen, JD, et al. Exercise is associated with reduced risk for incident dementia among persons 65 years of age and older. Ann Intern Med. 2006;144:7381.CrossRefGoogle ScholarPubMed
26.Szekely, A, Ronai, Z, Nemoda, Z, Kolmann, G, Gervai, J, Sasvari-Szekely, M. Human personality dimensions of persistence and harm avoidance associated with DRD4 and 5-HTTLPR polymorphisms. Am J Med Genet B Neuropsychiatr Genet. 2004;126:106110.CrossRefGoogle Scholar
27.Charney, DS. Psychobiological mechanisms of resilience and vulnerability: implications for successful adaptation to extreme stress. Am J Psychiatry. 2004;161:195216.CrossRefGoogle ScholarPubMed
28.Dudley, R. Limits to human locomotor performance: phylogenetic origins and comparative perspectives. J Exp Biol. 2001;204(pt 18):32353240.CrossRefGoogle ScholarPubMed
29.Ekkekakis, P, Hall, E, Petruzzello, S. Variation and homogeneity in affective responses to physical activity of varying intensities: an alternative perspective on dose response based on evolutionary considerations. J Sports Sci. 2005;23:477500.CrossRefGoogle ScholarPubMed
30.Bramble, DM, Lieberman, DE. Endurance running and the evolution of Homo. Nature. 2004;432:345352.CrossRefGoogle ScholarPubMed
31.Angeli, A, Minetto, M, Dovio, A, Paccotti, P. The overtraining syndrome in athletes: a stress-related disorder. J Endocrinol Invest. 2004;27:603612.CrossRefGoogle ScholarPubMed
32.Stafford, DE. Altered hypothalamic-pituitary-ovarian axis function in young female athletes: implications and recommendations for management. Treat Endocrinol. 2005;4:147154.CrossRefGoogle ScholarPubMed
33.Devereaux Melillo, K, Williamson, E, Futrell, M, Chamberlain, C. A self-assessment tool to measure older adults' perceptions regarding physical fitness and exercise activity. J Adv Nurs. 1997;25:12201226.CrossRefGoogle ScholarPubMed
34.Williams, JG, Purewal, RS. Development and initial validation of the Effort Sense Rating Scale (ESRS): a self-perceived index of physical fitness. Prev Med. 2001;32:103108.CrossRefGoogle ScholarPubMed
35.Colcombe, S, Kramer, AF. Fitness effects on the cognitive function of older adults: a meta-analytic study. Psychol Sci. 2003;14:125130.CrossRefGoogle ScholarPubMed
36.Heyn, P, Abreu, BC, Ottenbacher, KJ. The effects of exercise training on elderly persons with cognitive impairment and dementia: a meta-analysis. Arch Phys Med Rehabil. 2004;85:16941704.CrossRefGoogle ScholarPubMed
37.Lawlor, DA, Hopker, SW. The effectiveness of exercise as an intervention in the management of depression: systematic review and meta-regression analysis of randomised controlled trials. BMJ. 2001;322:763767.CrossRefGoogle ScholarPubMed
39.Brosse, AL, Sheets, ES, Lett, HS, Blumenthal, JA. Exercise and the treatment of clinical depression in adults: recent findings and future directions. Sports Med. 2002;32:741760.CrossRefGoogle ScholarPubMed
39.Broocks, A, Bandelow, B, Pekrun, G, et al. Comparison of aerobic exercise, clomipramine, and placebo in the treatment of panic disorder. Am J Psychiatry. 1998;155:603609.CrossRefGoogle ScholarPubMed
40.Jorm, AF, Christensen, H, Griffiths, KM, Parslow, RA, Rodgers, B, Blewitt, KA. Effectiveness of complementary and self-help treatments for anxiety disorders. Med J Aust. 2004;181(7 suppl):S29S46.CrossRefGoogle ScholarPubMed
41.Larun, L, Nordheim, LV, Ekeland, E, Hagen, KB, Heian, F. Exercise in prevention and treatment of anxiety and depression among children and young people. Cochrane Database Syst Rev. 2006;3:CD004691.Google Scholar
42.Karmisholt, K, Gotzsche, PC. Physical activity for secondary prevention of disease. Systematic reviews of randomised clinical trials. Dan Med Bull. 2005;52:9094.Google ScholarPubMed