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Risk of Parkinson’s disease among patients with herpes zoster: a nationwide longitudinal study

Published online by Cambridge University Press:  13 December 2019

Chih-Ming Cheng ,
Ya-Mei Bai ,
Chia-Fen Tsai ,
Shih-Jen Tsai ,
Yi-Hui Wu ,
Tai-Long Pan ,
Tzeng-Ji Chen  and
Mu-Hong Chen Open the ORCID record for Mu-Hong Chen [Opens in a new window]
Chih-Ming Cheng
Affiliation:
Department of Psychiatry, Taipei Veterans General Hospital, Taipei, Taiwan Division of Psychiatry, School of Medicine, National Yang-Ming University, Taipei, Taiwan Department of Psychiatry, Taipei Veterans General Hospital, Yuan Shan Branch, Yilan, Taiwan
Ya-Mei Bai
Affiliation:
Department of Psychiatry, Taipei Veterans General Hospital, Taipei, Taiwan Division of Psychiatry, School of Medicine, National Yang-Ming University, Taipei, Taiwan
Chia-Fen Tsai
Affiliation:
Department of Psychiatry, Taipei Veterans General Hospital, Taipei, Taiwan Division of Psychiatry, School of Medicine, National Yang-Ming University, Taipei, Taiwan
Shih-Jen Tsai
Affiliation:
Department of Psychiatry, Taipei Veterans General Hospital, Taipei, Taiwan Division of Psychiatry, School of Medicine, National Yang-Ming University, Taipei, Taiwan
Yi-Hui Wu
Affiliation:
Department of Neurology, Taipei Veterans General Hospital, Taipei, Taiwan Center for Geriatrics and Gerontology, Taipei Veterans General Hospital, Taipei, Taiwan
Tai-Long Pan*
Affiliation:
School of Traditional Chinese Medicine, Chang Gung University, Taoyuan, Taiwan Research Center for Industry of Human Ecology, Chang Gung University of Science and Technology, Taoyuan, Taiwan Liver Research Center, Division of Hepatology, Department of Gastroenterology and Hepatology, Chang Gung Memorial Hospital, Taoyuan, Taiwan
Tzeng-Ji Chen
Affiliation:
Department of Family Medicine, Taipei Veterans General Hospital, Taipei, Taiwan Institute of Hospital and Health Care Administration, National Yang-Ming University, Taipei, Taiwan
Mu-Hong Chen*
Affiliation:
Department of Psychiatry, Taipei Veterans General Hospital, Taipei, Taiwan Division of Psychiatry, School of Medicine, National Yang-Ming University, Taipei, Taiwan
*
*Mu-Hong Chen, MD, PhD Email: kremer7119@gmail.com
*Tai-Long Pan, PhD Email: pan@mail.cgu.edu.tw
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Abstract

Objective

Several studies suggested a potential role of viral infection in the pathophysiology of Parkinson’s disease (PD). However, the association between herpes zoster and PD was not investigated well till now.

Methods

Using the Taiwan National Health Insurance Research Database, 13 083 patients aged ≥45 years with herpes zoster and 52 332 (1:4) age-/sex-matched controls were enrolled between 1998 and 2008 and followed to the end of 2011. Those who developed PD during the follow-up period were identified.

Results

The Cox regression analysis with adjustment of demographic characteristics, health system utilization, and comorbidities demonstrated that patients with herpes zoster had an increased risk (hazard ratio [HR]: 1.80, 95% confidence interval [CI]: 1.43-2.28) of developing PD in later life compared to the control group. Sensitivity tests after excluding the first year (HR: 1.50, 95% CI: 1.16-1.93) and first 2-year (HR: 1.44, 95% CI: 1.10-1.88) observation periods showed consistent results.

Conclusions

Patients with herpes zoster were more likely to develop PD in later life compared to the controls. Additional studies are necessary for validating our results and to clarify the underlying pathophysiology between herpes zoster and PD.

Keywords

Herpes zosterParkinson’s diseaseTemporal association
Type
Original Research
Information
CNS Spectrums , Volume 25 , Issue 6 , December 2020 , pp. 797 - 802
Copyright
© Cambridge University Press 2019

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