Hostname: page-component-586b7cd67f-rdxmf Total loading time: 0 Render date: 2024-11-23T21:53:05.485Z Has data issue: false hasContentIssue false
  • English
  • Français

Risk of Parkinson’s disease among patients with herpes zoster: a nationwide longitudinal study

Published online by Cambridge University Press:  13 December 2019

Chih-Ming Cheng ,
Ya-Mei Bai ,
Chia-Fen Tsai ,
Shih-Jen Tsai ,
Yi-Hui Wu ,
Tai-Long Pan ,
Tzeng-Ji Chen  and
Mu-Hong Chen Open the ORCID record for Mu-Hong Chen [Opens in a new window]
Chih-Ming Cheng
Affiliation:
Department of Psychiatry, Taipei Veterans General Hospital, Taipei, Taiwan Division of Psychiatry, School of Medicine, National Yang-Ming University, Taipei, Taiwan Department of Psychiatry, Taipei Veterans General Hospital, Yuan Shan Branch, Yilan, Taiwan
Ya-Mei Bai
Affiliation:
Department of Psychiatry, Taipei Veterans General Hospital, Taipei, Taiwan Division of Psychiatry, School of Medicine, National Yang-Ming University, Taipei, Taiwan
Chia-Fen Tsai
Affiliation:
Department of Psychiatry, Taipei Veterans General Hospital, Taipei, Taiwan Division of Psychiatry, School of Medicine, National Yang-Ming University, Taipei, Taiwan
Shih-Jen Tsai
Affiliation:
Department of Psychiatry, Taipei Veterans General Hospital, Taipei, Taiwan Division of Psychiatry, School of Medicine, National Yang-Ming University, Taipei, Taiwan
Yi-Hui Wu
Affiliation:
Department of Neurology, Taipei Veterans General Hospital, Taipei, Taiwan Center for Geriatrics and Gerontology, Taipei Veterans General Hospital, Taipei, Taiwan
Tai-Long Pan*
Affiliation:
School of Traditional Chinese Medicine, Chang Gung University, Taoyuan, Taiwan Research Center for Industry of Human Ecology, Chang Gung University of Science and Technology, Taoyuan, Taiwan Liver Research Center, Division of Hepatology, Department of Gastroenterology and Hepatology, Chang Gung Memorial Hospital, Taoyuan, Taiwan
Tzeng-Ji Chen
Affiliation:
Department of Family Medicine, Taipei Veterans General Hospital, Taipei, Taiwan Institute of Hospital and Health Care Administration, National Yang-Ming University, Taipei, Taiwan
Mu-Hong Chen*
Affiliation:
Department of Psychiatry, Taipei Veterans General Hospital, Taipei, Taiwan Division of Psychiatry, School of Medicine, National Yang-Ming University, Taipei, Taiwan
*
*Mu-Hong Chen, MD, PhD Email: kremer7119@gmail.com
*Tai-Long Pan, PhD Email: pan@mail.cgu.edu.tw
Get access Rights & Permissions [Opens in a new window]

Abstract

Objective

Several studies suggested a potential role of viral infection in the pathophysiology of Parkinson’s disease (PD). However, the association between herpes zoster and PD was not investigated well till now.

Methods

Using the Taiwan National Health Insurance Research Database, 13 083 patients aged ≥45 years with herpes zoster and 52 332 (1:4) age-/sex-matched controls were enrolled between 1998 and 2008 and followed to the end of 2011. Those who developed PD during the follow-up period were identified.

Results

The Cox regression analysis with adjustment of demographic characteristics, health system utilization, and comorbidities demonstrated that patients with herpes zoster had an increased risk (hazard ratio [HR]: 1.80, 95% confidence interval [CI]: 1.43-2.28) of developing PD in later life compared to the control group. Sensitivity tests after excluding the first year (HR: 1.50, 95% CI: 1.16-1.93) and first 2-year (HR: 1.44, 95% CI: 1.10-1.88) observation periods showed consistent results.

Conclusions

Patients with herpes zoster were more likely to develop PD in later life compared to the controls. Additional studies are necessary for validating our results and to clarify the underlying pathophysiology between herpes zoster and PD.

Keywords

Herpes zosterParkinson’s diseaseTemporal association
Type
Original Research
Information
CNS Spectrums , Volume 25 , Issue 6 , December 2020 , pp. 797 - 802
Copyright
© Cambridge University Press 2019

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Coelho, M, Ferreira, JJ Late-stage Parkinson disease. Nat Rev Neurol. 2012;8(8):435–442.CrossRefGoogle ScholarPubMed
Fernandez, HH Nonmotor complications of Parkinson disease. Cleve Clin J Med. 2012;79(Suppl 2):S14–S18.CrossRefGoogle ScholarPubMed
Noyce, AJ, Bestwick, JP, Silveira-Moriyama, L, et al. Meta-analysis of early nonmotor features and risk factors for Parkinson disease. Ann Neurol. 2012;72(6):893–901.CrossRefGoogle ScholarPubMed
Kalia, LV, Lang, AE Parkinson's disease. Lancet. 2015;386(9996):896–912.CrossRefGoogle ScholarPubMed
Johnson, WG, Hodge, SE, Duvoisin, R. Twin studies and the genetics of Parkinson's disease—a reappraisal. Mov Disord. 1990;5(3):187–194.CrossRefGoogle ScholarPubMed
Tanner, CM, Ottman, R, Goldman, SM, et al. Parkinson disease in twins: an etiologic study. JAMA. 1999;281(4):341–346.CrossRefGoogle Scholar
Ward, CD, Duvoisin, RC, Ince, SE, Nutt, JD, Eldridge, R, Calne, DB Parkinson's disease in 65 pairs of twins and in a set of quadruplets. Neurology. 1983;33(7):815–824.CrossRefGoogle Scholar
Karim, S, Mirza, Z, Kamal, MA, et al. An association of virus infection with type 2 diabetes and Alzheimer's disease. CNS Neurol Disord Drug Targets. 2014;13(3):429–439.CrossRefGoogle ScholarPubMed
De Chiara, G, Marcocci, ME, Sgarbanti, R, et al. Infectious agents and neurodegeneration. Mol Neurobiol. 2012;46(3):614–638.CrossRefGoogle ScholarPubMed
Kumar, A, Calne, SM, Schulzer, M, et al. Clustering of Parkinson disease: shared cause or coincidence? Arch Neurol. 2004;61(7):1057–1060.CrossRefGoogle ScholarPubMed
Liu, B, Gao, HM, Hong, JS Parkinson's disease and exposure to infectious agents and pesticides and the occurrence of brain injuries: role of neuroinflammation. Environ Health Perspect. 2003;111(8):1065–1073.CrossRefGoogle ScholarPubMed
Woulfe, JM, Gray, MT, Gray, DA, Munoz, DG, Middeldorp, JM Hypothesis: a role for EBV-induced molecular mimicry in Parkinson's disease. Parkinsonism Relat Disord. 2014;20(7):685–694.CrossRefGoogle ScholarPubMed
Wang, WZ, Fang, XH, Cheng, XM, Jiang, DH, Lin, ZJ A case–control study on the environmental risk factors of Parkinson's disease in Tianjin, China. Neuroepidemiology. 1993;12(4):209–218.CrossRefGoogle ScholarPubMed
Marttila, RJ, Rinne, UK, Halonen, P, Madden, DL, Sever, JL Herpesviruses and parkinsonism. Herpes simplex virus types 1 and 2, and cytomegalovirus antibodies in serum and CSF. Arch Neurol. 1981;38(1):19–21.CrossRefGoogle ScholarPubMed
Vlajinac, H, Dzoljic, E, Maksimovic, J, Marinkovic, J, Sipetic, S, Kostic, V. Infections as a risk factor for Parkinson's disease: a case–control study. Int J Neurosci. 2013;123(5):329–332.CrossRefGoogle ScholarPubMed
Bu, XL, Wang, X, Xiang, Y, et al. The association between infectious burden and Parkinson's disease: a case–control study. Parkinsonism Relat Disord. 2015;21(8):877–881.CrossRefGoogle ScholarPubMed
Hassani, A, Corboy, JR, Al-Salam, S, Khan, G. Epstein-Barr virus is present in the brain of most cases of multiple sclerosis and may engage more than just B cells. PLoS ONE. 2018;13(2):e0192109.CrossRefGoogle ScholarPubMed
Jha, HC, Mehta, D, Lu, J, et al. Gamma herpes virus infection of human neuronal cells. MBio. 2015;6(6):e01844–e01815.CrossRefGoogle Scholar
Cohen, JI Clinical practice: herpes zoster. N Engl J Med. 2013;369(3):255–263.CrossRefGoogle ScholarPubMed
Almeida, OP, Lautenschlager, NT Dementia associated with infectious diseases. Int Psychogeriatr. 2005;17 Suppl 1:S65–S77.CrossRefGoogle ScholarPubMed
Bangen, KJ, Delano-Wood, L, Wierenga, CE, Stricker, NH, Hesselink, JR, Bondi, MW. Dementia following herpes zoster encephalitis. Clin Neuropsychol. 2010;24(7):1193–1203.CrossRefGoogle ScholarPubMed
Grahn, A, Nilsson, S, Nordlund, A, Linden, T, Studahl, M. Cognitive impairment 3 years after neurological Varicella-zoster virus infection: a long-term case control study. J Neurol. 2013;260(11):2761–2769.CrossRefGoogle ScholarPubMed
Ragozzino, MW, Kurland, LT, Rajput, AH Investigation of the association between herpes zoster and Parkinson's disease. Neuroepidemiology. 1983;2(1–2): 89–92.CrossRefGoogle Scholar
Hemling, N, Roytta, M, Rinne, J, et al. Herpesviruses in brains in Alzheimer's and Parkinson's diseases. Ann Neurol. 2003;54(2):267–271.CrossRefGoogle ScholarPubMed
Harris, MA, Tsui, JK, Marion, SA, Shen, H, Teschke, K. Association of Parkinson's disease with infections and occupational exposure to possible vectors. Mov Disord. 2012;27(9):1111–1117.CrossRefGoogle ScholarPubMed
Lai, SW, Lin, CH, Lin, HF, Lin, CL, Lin, CC, Liao, KF Herpes zoster correlates with increased risk of Parkinson's disease in older people: a population-based cohort study in Taiwan. Medicine. 2017;96(7):e6075.CrossRefGoogle ScholarPubMed
Chen, MH, Su, TP, Chen, YS, et al. Attention deficit hyperactivity disorder, tic disorder, and allergy: is there a link? A nationwide population-based study. J Child Psychol Psychiatry Allied Discipl. 2013;54(5):545–551.CrossRefGoogle Scholar
Chen, MH, Su, TP, Chen, YS, et al. Asthma and attention-deficit/hyperactivity disorder: a nationwide population-based prospective cohort study. J Child Psychol Psychiatry Allied Discipl. 2013;54(11):1208–1214.CrossRefGoogle ScholarPubMed
Li, CT, Bai, YM, Huang, YL, et al. Association between antidepressant resistance in unipolar depression and subsequent bipolar disorder: cohort study. Br J Psychiatry. 2012;200(1):45–51.Google ScholarPubMed
Shen, CC, Tsai, SJ, Perng, CL, Kuo, BI, Yang, AC Risk of Parkinson disease after depression: a nationwide population-based study. Neurology. 2013;81(17):1538–1544.Google ScholarPubMed
Staikov, I, Neykov, N, Marinovic, B, Lipozencic, J, Tsankov, N. Herpes zoster as a systemic disease. Clin Dermatol. 2014;32(3):424–429.CrossRefGoogle ScholarPubMed
Marttila, RJ, Rinne, UK, Tiilikainen, A. Virus antibodies in Parkinson's disease. Herpes simplex and measles virus antibodies in serum and CSF and their relation to HLA types. J Neurol Sci. 1982;54(2):227–238.CrossRefGoogle ScholarPubMed
Reale, M, Iarlori, C, Thomas, A, et al. Peripheral cytokines profile in Parkinson's disease. Brain Behav Immun. 2009;23(1):55–63.CrossRefGoogle ScholarPubMed
Mogi, M, Harada, M, Kondo, T, et al. Interleukin-1 beta, interleukin-6, epidermal growth factor and transforming growth factor-alpha are elevated in the brain from parkinsonian patients. Neurosci Lett. 1994;180(2):147–150.CrossRefGoogle ScholarPubMed
Mogi, M, Harada, M, Riederer, P, Narabayashi, H, Fujita, K, Nagatsu, T. Tumor necrosis factor-alpha (TNF-alpha) increases both in the brain and in the cerebrospinal fluid from parkinsonian patients. Neurosci Lett. 1994;165(1–2):208–210.CrossRefGoogle ScholarPubMed
Block, ML, Zecca, L, Hong, JS Microglia-mediated neurotoxicity: uncovering the molecular mechanisms. Nat Rev Neurosci. 2007;8(1):57–69.CrossRefGoogle ScholarPubMed
Lawson, LJ, Perry, VH, Dri, P, Gordon, S. Heterogeneity in the distribution and morphology of microglia in the normal adult mouse brain. Neuroscience. 1990;39(1):151–170.CrossRefGoogle ScholarPubMed
Supplementary material: File

Cheng et al. supplementary material

Table S1

Download Cheng et al. supplementary material(File)
File 50.2 KB