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The Effects of TMS on Animal Models of Depression, β-Adrenergic Receptors, and Brain Monoamines

Published online by Cambridge University Press:  07 November 2014

R.H. Belmaker ,
Nimrod Grisaru ,
Dorit Ben-Shahar  and
Ehud Klein
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Abstract

In initial studies using animal models of depression, we primarily focused on the similarities of transcranial magnetic stimulation (TMS) to electroconvulsive therapy (ECT). However, our investigations show that TMS has its own, unique, potentially diagnostic and therapeutic effects, distinct from those of ECT. These effects need further exploration in animal and clinical studies.

Type
Feature Articles
Information
CNS Spectrums , Volume 2 , Issue 1: Transcranial Magnetic Stimulation: Mapping & Modifying Brain-Behavior Relationships , January 1997 , pp. 26 - 30
Copyright
Copyright © Cambridge University Press 1997

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References

1.Hallet, M, Cohen, LG. Magnetism: a new method for stimulation of nerve and brain. JAMA. 1989;262:538–541.Google Scholar
2.Pascual-Leone, A, Valls-Sole, J, Brasil-Neto, JP, Cohen, LG, Hallet, M. Akinesia in Parkinson's disease. Part 1. Shortening of simple reaction time with focal, single-pulse TMS. Neurology. 1994;44:884–891.Google Scholar
3.Pascual-Leone, A, Valls-Sole, J, Brasil-Neto, JP, Cammarota, A, Grafman, J, Hallet, M. Akinesia in Parkinson's disease. Part 2. Effects of subthreshold repetitive transcranial motor cortex stimulation. Neurology. 1994;44:892–898.Google Scholar
4.Grisaru, N, Yaroslavsky, U, Abarbanel, J, Lamberg, T, Belmaker, RH. Transcranial magnetic stimulation in depression and schizophrenia. European Neuropsychopharmacol. 1994;4:287–288.CrossRefGoogle Scholar
5.Geller, V, Grisaru, N, Abarbanel, JM, Lemberg, T, Belmaker, RH. Transcranial magnetic stimulation of the frontal lobe in depression and schizophrenia. Progress in Neuropsychopharmacol and Biol Psychiatry. In press.Google Scholar
6.Kolbinger, HM, Hoflich, G, Hufnagel, A, Moller, HJ, Kasper, S. Transcranial magnetic stimulation (TMS) in the treatment of major depression—a pilot study. Hum Psychopharmacol. 1995;10:305–310.CrossRefGoogle Scholar
7.George, MS, Wassermann, EM, Williams, WA, et al.Daily repetitive transcranial magnetic stimulation (rTMS) improves refractory depression. NeuroReport. 1995;6:14.Google Scholar
8.Fleischmann, A, Steppel, J, Leon, A, Belmaker, RH. The effect of transcranial magnetic stimulation compared with electroconvulsive shock on rat apomorphine-induced stereotypy. European Neuropsychopharmacol. 1994;4:449–450.Google Scholar
9.Fleischmann, A, Prolov, K, Abarbanel, J, Belmaker, RH. The effect of transcranial magnetic stimulation of rat brain on behavioral models of depression. Brain Res. 1995;699:130–132.Google Scholar
10.Potter, WZ, Rudorfer, MV. Electroconvulsive therapy—a modern medical procedure. N Engl J Med. 1993;328:882–883.Google Scholar
11.Modigh, K, Balldin, J, Eriksson, E, Granerus, AK, Walinder, J. Increased responsiveness of dopamine receptors after ECT: a review of experimental and clinical evidence. In: Lerer, B, Weiner, RD, Belmaker, RH, eds. ECT: Basic Mechanisms. London: John Libbey; 1984:18–27.Google Scholar
12.Porsolt, RD, Bertin, A, Blavet, N. Immobility induced by forced swimming in rats: effects of agents that modify central catecholamine and serotonin activity. Eur J Pharmacol. 1979;57:201–220.Google Scholar
13.Sackeim, HA, Decina, P, Prohovnik, I, Portnoy, S, Kanzler, M, Malitz, S. Dosage, seizure threshold, and the antidepressant efficacy of electroconvulsive therapy. Ann NY Acad Sci. 1986;462:398–410.Google Scholar
14.Bolwig, TG. The influence of electrically-induced seizures on deep brain structures. In: Lerer, B, Weiner, RD, Belmaker, RH, eds: ECT: Basic Mechanisms. London: John Libbey; 1984:132–138.Google Scholar
15.Kellar, KJ, Cascio, CS, Bergstrom, DA, Butler, JA, Iadarola, P. Electroconvulsive shock and reserpine: effects on beta-adrenergic receptors in rat brain. J Neurochem. 1981;37:830–836.CrossRefGoogle ScholarPubMed
16.Fleischmann, A, Sternheim, A, Etgen, AM, Li, C, Grisaru, N, Belmaker, RH. Transcranial magnetic stimulation downregulates β-adrenoreceptors in rat cortex. J Neural Transmission. In press.Google Scholar
17.Didier, M, Zin, R, Urien, S, Sapena, R, Tillement, JP. Labelling of rat brain b-adrenoceptors: [3H]CGP-12177 or [125I]iodocyanopindolol? J Receptor Res. 1992;12:369–387.Google Scholar
18.Ben-Shachar, D, Belmaker, RH, Grisaru, N, Klein, E. Transcranial magnetic stimulation induces alterations in brain monoamines. [Manuscript under review]Google Scholar
19.Graham-Smith, DG, Green, AR, Costain, DW. Mechanism of the antidepressant action of electroconvulsive therapy. Lancet. 1978;1:254–256.Google Scholar
20.Lerer, B, Belmaker, RH. Receptors and the mechanism of action of ECT. Biol Psychiatr. 1982;17:497–511.Google ScholarPubMed
21.Sackeim, HA, Prudig, J, Devanand, DP, et al.Effects of stimulus intensity and electrode placement on the efficacy and cognitive effects of electroconvulsive therapy. N Engl J Med. 1993;328:839–846.CrossRefGoogle ScholarPubMed
22.Barker, AT. An introduction to the basic principles of magnetic nerve stimulation. J Clin Neurophysiol. 1991;8:26–37.CrossRefGoogle Scholar
23.Bates, MN. Extremely low frequency electromagnetic fields and cancer: the epidemiological evidence. Environ Health Perspect. 1991;95:147–156.Google Scholar
24.Glue, P, Costello, MJ, Pert, A, Mele, A, Nutt, DJ. Regional neurotransmitter responses after acute and chronic electroconvulsive shock. Psychopharmacol. 1990;100:60–65.Google Scholar
25.Zis, AP, Nomikos, GG, Brown, EE, Damsma, G, Fibiger, HC. Neurochemical effects of electrically and chemically induced seizures: an in vivo microdialysis study in the rat hippocampus. Neuropsychopharmacol. 1992;7:189–195.Google Scholar
26.Zis, AP, Nomikos, GG, Brown, EE, Damsma, G, Fibiger, HC. Neurochemical effects of electrically and chemically induced seizures: an in vivo microdialysis study in the rat hippocampus. Neuropsychopharmacol. 1992;7:189–195.Google Scholar
27.McGarvey, KA, Zis, AP, Brown, EE, Nomikos, GG, Fibiger, HC. ECS-induced dopamine release: Effects of electrode placement, anticonvulsant treatment and stimulus intensity. Biol Psychialr. 1993;34:152–157.Google Scholar
28.Ebert, MH, Baldessarini, RJ, Lipinski, JF, Berv, K. Effects of electroconvulsive seizures on amine metabolism in the rat brain. Arch Gen Psychiatry. 1973;29:397–401.Google Scholar
29.Nimgaonkar, VL, Heal, DJ, Davies, CL, Green, AR. Studies on rat brain catecholamine synthesis and beta-adrenoreceptor number following administration of electroconvulsive shock, desipramine, and clenbuterol. J Neural Transm. 1986;63:245–259.Google Scholar
30.Green, AR, Heal, DJ, Vincent, ND. The effects of single and repeated electroconvulsive shock administration on the release of 5-hydroxytryptamine and noradrenaline from cortical slices of rat brain. Br J Pharmacol. 1987;92:25–30.Google Scholar
31.Stone, EA. Stress and catecholamines. In: Friedhoff, AJ, ed. Catecholamines and Behavior. Vol. 2 of Neuropsychopharmacology. New York: Plenum Press; 1975:31–72.Google Scholar
32.Dunn, AJ. Stress-related changes in the cerebral calecholamine and indoleamine metabolism: lack of effect of adrenalectomy and corticosterone. J Neurochem. 1988;51:406–412.Google Scholar
33.George, MS, Wassermann, EM, Kimbrell, TA, et al.Daily left prefrontal rTMS improves mood in depression: a placebo-controlled crossover trial. Am J Psychiatry. [Manuscript submitted]Google Scholar
34.Pascual-Leone, A, Rubio, B, Pallardo, F, Catala, DM. Beneficial effect of rapid-rate transcranial magnetic stimulation of the left dorsolateral prefrontal cortex in drug-resistant depression. Lancet. 996;347:233–237.Google Scholar