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Child maltreatment, inflammation, and internalizing symptoms: Investigating the roles of C-reactive protein, gene variation, and neuroendocrine regulation

Published online by Cambridge University Press:  06 May 2015

Dante Cicchetti ,
Elizabeth D. Handley  and
Fred A. Rogosch
Dante Cicchetti*
Affiliation:
University of Minnesota Institute of Child Development University of Rochester Mt. Hope Family Center
Elizabeth D. Handley
Affiliation:
University of Rochester Mt. Hope Family Center
Fred A. Rogosch
Affiliation:
University of Rochester Mt. Hope Family Center
*
Address correspondence and reprint requests to: Dante Cicchetti, Institute of Child Development, University of Minnesota, 51 East River Road, Minneapolis, MN 55455; E-mail: cicchett@umn.edu.
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Abstract

Prior research has found inconsistent evidence regarding the association among childhood adversity, inflammation, and internalizing symptoms, perhaps because previous studies have yet to adequately integrate important factors such as the timing of the adversity, genetic variation, and other relevant processes such as neuroendocrine regulation. The aims of the present study were threefold: (a) to determine whether the effect of the timing of child maltreatment on C-reactive protein (CRP), an inflammatory marker, varies by CRP gene variation; (b) to explore whether links between salivary CRP and childhood internalizing symptoms depend on the presence and timing of maltreatment experiences; and (c) to investigate the role of CRP in the relations between child neuroendocrine regulation and internalizing symptoms and examine whether these associations are moderated by the presence and timing of child maltreatment. Participants included a sample of 267 maltreated and 222 nonmaltreated children (M age = 9.72, SD = 0.99; 52.4% male; 66% African American) who attended a summer day camp research program designed for school-aged low-income children. Department of Human Services records were examined to determine the onset and recency of maltreatment for children in the maltreated group. The results indicated that among children with recent onset maltreatment, those with at least one A allele from CRP single nucleotide polymorphism rs1417938 evidenced significantly higher CRP levels compared to recently maltreated children carrying the TT genotype. Moreover, higher levels of CRP were associated with higher levels of internalizing symptoms only for recently maltreated children. Finally, we did not find support for salivary CRP as a mechanism in the relation between neuroendocrine regulation and childhood internalizing symptoms. Our findings highlight the importance of the timing of child maltreatment and have important implications for characterizing variability in inflammation and internalizing symptoms among youth.

Type
Regular Articles
Information
Development and Psychopathology , Volume 27 , Special Issue 2: Neural Plasticity, Sensitive Periods, and Psychopathology , May 2015 , pp. 553 - 566
Copyright
Copyright © Cambridge University Press 2015 

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References

Achenbach, T. M. (1991). Manual for the Teacher Report Form and 1991 profile. Burlington, VT: University of Vermont, Department of Psychiatry.Google Scholar
Anda, R. F., Dube, S. R., & Giles, W. H. (2006). The enduring effects of abuse and related adverse experiences in childhood. European Archives of Psychiatry and Clinical Neuroscience, 256, 174–186.CrossRefGoogle ScholarPubMed
Barnett, D., Manly, J. T., & Cicchetti, D. (1993). Defining child maltreatment: The interface between policy and research. In Cicchetti, D. & Toth, S. L. (Eds.), Child abuse, child development, and social policy (pp. 7–74). Norwood, NJ: Ablex.Google Scholar
Blair, C., & Diamond, A. (2008). Biological processes in prevention and intervention: The promotion of self-regulation as a means of preventing school failure. Development and Psychopathology, 20, 899–911.CrossRefGoogle ScholarPubMed
Bufalino, C., Hepgul, N., Aguglia, E., & Pariante, C. M. (2012). The role of immune genes in the association between depression and inflammation: A review of recent clinical studies. Brain, Behavior, and Immunity, 31, 31–47.CrossRefGoogle ScholarPubMed
Cicchetti, D. (2002). How a child builds a brain: Insights from normality and psychopathology. In Hartup, W. & Weinberg, R. (Eds.), Minnesota symposia on child psychology: Child psychology in retrospect and prospect (Vol. 32, pp. 23–71). Mahwah, NJ: Erlbaum.Google Scholar
Cicchetti, D., & Dawson, G. (2002). Multiple levels of analysis. Development and Psychopathology, 14, 417–420.CrossRefGoogle ScholarPubMed
Cicchetti, D., & Gunnar, M. R. (2008). Integrating biological processes into the design and evaluation of preventive interventions. Development and Psychopathology, 20, 737–743.CrossRefGoogle Scholar
Cicchetti, D., & Lynch, M. (1993). Toward an ecological/transactional model of community violence and child maltreatment: Consequences for children's development. Psychiatry, 56, 96–118.CrossRefGoogle ScholarPubMed
Cicchetti, D., & Lynch, M. (1995). Failures in the expectable environment and their impact on individual development: The case of child maltreatment. In Cicchetti, D. & Cohen, D. J. (Eds.), Developmental psychopathology: Risk, disorder, and adaptation (Vol. 2, pp. 32–71). New York: Wiley.Google Scholar
Cicchetti, D., & Manly, J. T. (1990). A personal perspective on conducting research with maltreating families: Problems and solutions. In Brody, G. & Sigel, I. (Eds.), Methods of family research: Families at risk (Vol. 2, pp. 87–133). Hillsdale, NJ: Erlbaum.Google Scholar
Cicchetti, D., & Manly, J. T. (Eds.). (2001). Operationalizing child maltreatment: Developmental processes and outcomes [Special Issue]. Development and Psychopathology, 13, 755–1048.CrossRefGoogle ScholarPubMed
Cicchetti, D., & Rizley, R. (1981). Developmental perspectives on the etiology, intergenerational transmission and sequelae of child maltreatment. New Directions for Child Development, 11, 31–55.CrossRefGoogle Scholar
Cicchetti, D., & Rogosch, F. A. (1996). Equifinality and multifinality in developmental psychopathology. Development and Psychopathology, 8, 597–600.CrossRefGoogle Scholar
Cicchetti, D., & Rogosch, F. A. (1997). The role of self-organization in the promotion of resilience in maltreated children. Development and Psychopathology, 9, 797–815.CrossRefGoogle ScholarPubMed
Cicchetti, D., & Rogosch, F. (2001). Diverse patterns of neuroendocrine activity in maltreated children. Developmental Psychopathology, 13, 677–693.CrossRefGoogle ScholarPubMed
Cicchetti, D., Rogosch, F. A., Gunnar, M. R., & Toth, S. L. (2010). The differential impacts of early abuse on internalizing problems and diurnal cortisol activity in school-aged children. Child Development, 25, 252–269.CrossRefGoogle Scholar
Cicchetti, D., Rogosch, F. A., Lynch, M., & Holt, K. (1993). Resilience in maltreated children: Processes leading to adaptive outcome. Development and Psychopathology, 5, 629–647.CrossRefGoogle Scholar
Cicchetti, D. C., Rogosch, F. A., & Oshri, A. (2011). Interactive effects of corticotropin releasing hormone receptor 1, serotonin transporter linked polymorphic region, and child maltreatment on diurnal cortisol regulation and internalizing symptomatology. Development and Psychopathology, 23, 1125–1138.CrossRefGoogle ScholarPubMed
Cicchetti, D., Rogosch, F. A., & Toth, S. L. (2006). Fostering secure attachment in infants in maltreating families through preventive interventions. Development and Psychopathology, 18, 623–650.CrossRefGoogle ScholarPubMed
Cicchetti, D., Rogosch, F. A., Toth, S. L., & Sturge-Apple, M. L. (2011). Normalizing the development of cortisol regulation in maltreated infants through preventive interventions. Development and Psychopathology, 23, 789–800.CrossRefGoogle ScholarPubMed
Cicchetti, D., & Toth, S. L. (2009). A developmental psychopathology perspective on adolescent depression. In Nolen-Hoeksema, S. & Hilt, L. (Eds.), Handbook of adolescent depression. (pp. 3–31). New York: Taylor & Francis.Google Scholar
Cicchetti, D., & Toth, S. L. (in press). Child maltreatment. In Lamb, M. & Coll, C. Garcia (Eds.), Handbook of child psychology and developmental science: Vol. 3. Socioemotional process (7th ed.). New York: Wiley.Google Scholar
Cicchetti, D., Toth, S. L., & Manly, J. T. (2003). Maternal Maltreatment Classification Interview. Unpublished manuscript, Mt. Hope Family Center, Rochester, NY.Google Scholar
Cicchetti, D., & Tucker, D. (1994). Development and self-regulatory structures of the mind. Development and Psychopathology, 6, 533–549.CrossRefGoogle Scholar
Cicchetti, D., & Valentino, K. (2006). An ecological transactional perspective on child maltreatment: Failure of the average expectable environment and its influence upon child development. In Cicchetti, D. & Cohen, D. J. (Eds.), Developmental psychopathology (Vol. 3, pp. 129–201). Hoboken, NJ: Wiley.Google ScholarPubMed
Coelho, R., Viola, T. W., Walss-Bass, C., Brietzke, E., & Grassi-Oliveira, R. (2014). Childhood maltreatment and inflammatory markers: A systematic review. Acta Psychiatrica Scandinavica, 129, 180–192.CrossRefGoogle ScholarPubMed
Courchesne, E., Chisum, H., & Townsend, J. (1994). Neural activity-dependent changes in development: Implications for psychopathology. Development and Psychopathology, 6, 741–758.CrossRefGoogle Scholar
Curtis, W. J., & Cicchetti, D. (2013). Affective facial expression processing in 15-month-old infants who have experienced maltreatment: An event-related study. Child Maltreatment, 18, 140–154.CrossRefGoogle Scholar
Danese, A., Caspi, A., Williams, B., Ambler, A., Sugden, K., Mika, J., et al. (2011). Biological embedding of stress through inflammation processes in childhood. Molecular Psychiatry, 16, 244–246.CrossRefGoogle ScholarPubMed
Danese, A., & McEwen, B. S. (2012). Adverse childhood experiences, allostasis, allostatic load, and age-related disease. Physiology & Behavior, 106, 29–39.CrossRefGoogle ScholarPubMed
Danese, A., Moffitt, T. E., Harrington, H., Milne, B. J., Polanczyk, G., Pariante, C. M., et al. (2009). Adverse childhood experiences and adult risk factors for age-related disease: Depression, inflammation, and clustering of metabolic risk markers. Archives of Pediatric and Adolescent Medicine, 163, 1135–1143.CrossRefGoogle ScholarPubMed
Danese, A., Moffitt, T. E., Pariante, C. M., Ambler, A., Poulton, R., & Caspi, A. (2008). Elevated inflammation levels in depressed adults with a history of childhood maltreatment. Archives of General Psychiatry, 65, 409–415.CrossRefGoogle ScholarPubMed
Danese, A., Pariante, C. M., Caspi, A., Taylor, A., & Poulton, R. (2007). Childhood maltreatment predicts adult inflammation in a life-course study. Proceedings of the National Academy of Sciences, 104, 1319–1324.CrossRefGoogle Scholar
Danese, A., & Tan, M. (2014). Childhood maltreatment and obesity: A systematic review and meta-analysis. Molecular Psychiatry, 19, 544–554.CrossRefGoogle ScholarPubMed
DeBellis, M. D. (2001). Developmental traumatology: The psychobiological development of maltreated children and its implications for research, treatment, and policy. Development and Psychopathology, 13, 539–564.CrossRefGoogle Scholar
DeBellis, M. D. (2005). The psychobiology of neglect. Child Maltreatment, 10, 150–172.CrossRefGoogle Scholar
Dozier, M., Peloso, E., Lewis, E., Laurenceau, J. P., & Levine, S. (2008). Effects of an attachment-based intervention on the cortisol production of infants and toddlers in foster care. Development and Psychopathology, 20, 845–859.CrossRefGoogle ScholarPubMed
Dunn, E. C., McLaughlin, K. A., Slopen, N., Rosand, J., & Smoller, J. W. (2013). Developmental timing of maltreatment and symptoms of depression and suicidal ideation in young adulthood: Results from the National Longitudinal Study of Adolescent Health. Depression and Anxiety, 30, 955–964.Google ScholarPubMed
Falush, D., Stephens, M., & Pritchard, J. K. (2003). Inference of population structure using multilocus genotype data: Linked loci and correlated allele frequencies. Genetics, 164, 1567–1587.CrossRefGoogle ScholarPubMed
Falush, D., Stephens, M., & Pritchard, J. K. (2007). Inference of population structure using multilocus genotype data: Dominant markers and null alleles. Molecular Ecology Notes, 7, 574–578.CrossRefGoogle ScholarPubMed
Fang, X., Brown, D. S., Florence, C. S., & Mercy, J. A. (2012). The economic burden of child maltreatment in the United States and implications for prevention. Child Abuse & Neglect, 36, 156–165.CrossRefGoogle ScholarPubMed
Felitti, V. J., Anda, R. F., Nordenberg, D., Williamson, D. F., Spitz, A. M., Edwards, V., et al. (1998). Relationship of childhood abuse and household dysfunction to many of the leading causes of death in adults: The Adverse Childhood Experiences (ACE) study. American Journal of Preventive Medicine, 14, 245–258.CrossRefGoogle ScholarPubMed
Gimeno, D., Kivimaki, M., Brunner, E. J., Elovainio, M., De Vogli, R., Steptoe, A., et al. (2009). Associations of C-reactive protein and interleukin-6 with cognitive symptoms of depression: 12-year follow-up of the Whitehall II study. Psychological Medicine, 39, 413–423.CrossRefGoogle ScholarPubMed
Gottlieb, G. (1992). Individual development and evolution: The genesis of novel behavior. New York: Oxford University Press.Google Scholar
Gunnar, M. R., & Vasquez, D. (2006). Stress neurobiology and developmental psychopathology. In Cicchetti, D. & Cohen, D. J. (Eds.), Developmental psychopathology (Vol. 3, pp. 533–577). Hoboken, NJ: Wiley.Google Scholar
Halder, I., Marsland, A. L., Cheong, J., Muldoon, M. F., Ferrell, R. E., & Manuck, S. B. (2010). Polymorphisms in the CRP gene moderate an association between depressive symptoms and circulating levels of C reactive protein. Brain, Behavior, and Immunity, 24, 160–167.CrossRefGoogle ScholarPubMed
Hart, H., & Rubia, K. (2012). Neuroimaging of child abuse: A critical review. Frontiers in Human Neuroscience, 6, 52.CrossRefGoogle ScholarPubMed
Heckman, J. J. (2006). Skill formation and the economics of investing in disadvantaged children. Science, 312, 1900–1902.CrossRefGoogle ScholarPubMed
Hostinar, C. E., Sullivan, R., & Gunnar, M. R. (2013). Psychobiological mechanisms underlying the social buffering of stress: A review of animal models and human studies across development. Psychological Bulletin. Advance online publication.Google Scholar
Hubisz, M. J., Falush, D., Stephens, M., & Pritchard, J. K. (2009). Inferring weak population structure with the assistance of sample group information. Molecular Ecology Resources, 9, 1322–1332.CrossRefGoogle ScholarPubMed
Juster, R. P., Bizik, G., Picard, M., Arsenault-Lapierre, G., Sindi, S., Trepanier, L., et al. (2011). A transdisciplinary perspective of chronic stress in relation to psychopathology throughout life span development. Development and Psychopathology, 23, 725–776.CrossRefGoogle ScholarPubMed
Juster, R. P., McEwen, B. S., & Lupien, S. J. (2010). Allostatic load biomarkers of chronic stress and impact on health and cognition. Neuroscience & Biobehavioral Reviews, 35, 2–16.CrossRefGoogle ScholarPubMed
Kaplow, J. B., & Widom, C. S. (2007). Age of onset of maltreatment predicts long-term mental health outcomes. Journal of Abnormal Psychology, 116, 176–187.CrossRefGoogle ScholarPubMed
Keller, M. C. (2014). Gene × Environment interaction studies have not properly controlled for potential confounders: The problem and the (simple) solution. Biological Psychiatry, 75, 18–24.CrossRefGoogle Scholar
Lai, C. Q., Tucker, K. L., Choudhry, S., Parnell, L. D., Mattei, J., Garcia-Bailo, B., et al. (2009). Population admixture associated with disease prevalence in the Boston Puerto Rican health study. Human Genetics, 125, 199–205.CrossRefGoogle ScholarPubMed
Lanier, P., Jonson-Reid, M., Stahlschmidt, M., Drake, B., & Constantino, J. (2010). Child maltreatment and pediatric health outcomes: A longitudinal study of low-income children. Journal of Pediatric Psychology, 35, 511–522.CrossRefGoogle ScholarPubMed
Lee, Y. (2010). Fibromyalgia and childhood abuse: Exploration of stress reactivity as a developmental mediator. Developmental Review, 30, 294–307.CrossRefGoogle Scholar
Lupien, S. J., McEwen, B. S., Gunnar, M. R., & Heim, C. (2009). Effects of stress throughout the lifespan on the brain, behavior and cognition. Nature Reviews Neuroscience, 10, 434–445.CrossRefGoogle Scholar
Manly, J. T. (2005). Advances in research definitions of child maltreatment. Child Abuse & Neglect, 29, 425–439.CrossRefGoogle Scholar
Manly, J. T., Kim, J. E., Rogosch, F. A., & Cicchetti, D. (2001). Dimensions of child maltreatment and children's adjustment: Contributions of developmental timing and subtype. Development and Psychopathology, 13, 759–782.CrossRefGoogle ScholarPubMed
Masten, A. S., & Cicchetti, D. (2010). Developmental cascades. Development and Psychopathology, 22, 491–495.CrossRefGoogle ScholarPubMed
McCrory, E., De Brito, S. A., & Viding, E. (2010). Research Review: The neurobiology and genetics of maltreatment and adversity. Journal of Child Psychology and Psychiatry, 51, 1079–1095.CrossRefGoogle ScholarPubMed
McEwen, B. (2003). Mood disorders and allostatic load. Biological Psychiatry, 54, 200–207.CrossRefGoogle ScholarPubMed
Miller, G. E., Brody, G. H., Yu, T., & Chen, E. (2014). Mitigating the effects of childhood disadvantage: Family-oriented intervention reduces inflammation in low-SES African American youth. Proceedings of the National Academy of Sciences, 111, 11287–11292.CrossRefGoogle Scholar
Miller, G. E., Chen, E., & Parker, K. J. (2011). Psychological stress in childhood and susceptibility to the chronic diseases of aging: Moving toward a model of behavioral and biological mechanisms. Psychological Bulletin, 137, 959–997.CrossRefGoogle Scholar
Muthén, L. K., & Muthén, B. O. (1998–2012). Mplus user's guide (7th ed.). Los Angeles: Author.Google Scholar
Ouellet-Morin, I., Danese, A., Williams, B., & Arseneault, L. (2011). Validation of a high-sensitivity assay for C-reactive protein in human saliva. Brain, Behavior, and Immunity, 25, 640–646.CrossRefGoogle ScholarPubMed
Pollak, S. D., Cicchetti, D., Klorman, R., & Brumaghim, J. (1997). Cognitive brain event-related potentials and emotion processing in maltreated children. Child Development, 68, 773–787.CrossRefGoogle ScholarPubMed
Reichlin, S. (1993). Neuroendocrine-immune interactions. New England Journal of Medicine, 329, 1246–1253.Google ScholarPubMed
Rogosch, F. A., Cicchetti, D., Shields, A., & Toth, S. L. (1995). Parenting dysfunction in child maltreatment. In Bornstein, M. H. (Ed.), Handbook of parenting: Applied and practical parenting (Vol. 4, pp. 127–159). Hillsdale, NJ: Erlbaum.Google Scholar
Rogosch, F. A., Dackis, M. N., & Cicchetti, D. (2011). Child maltreatment and allostatic load: Consequences for physical and mental health in children from low-income families. Development and Psychopathology, 23, 1107–1124.CrossRefGoogle ScholarPubMed
Schwartz, E. B., Granger, D. A., Susman, E. J., Gunnar, M. R., & Laird, B. (1998). Assessing salivary cortisol in studies of child development. Child Development, 69, 1503–1513.CrossRefGoogle ScholarPubMed
Sedlak, A. J., Mettenburg, J., Basena, M., Petta, I., McPherson, K., Greene, A., et al. (2010). Fourth National Incidence Study of child abuse and neglect (NIS–4): Report to Congress. Washington, DC: US Department of Health and Human Services, Administration for Children and Families.Google Scholar
Shirtcliff, E. A., Coe, C. L., & Pollak, S. D. (2009). Early childhood stress is associated with elevated antibody levels to herpes simplex virus type 1. Proceedings of the National Academy of Sciences, 106, 2963–2967.CrossRefGoogle ScholarPubMed
Shonkoff, J. P., Boyce, W. T., & McEwen, B. S. (2009). Neuroscience, molecular biology, and the childhood roots of health disparities: Building a new framework for health promotion and disease prevention. Journal of the American Medical Association, 301, 2252–2259.CrossRefGoogle ScholarPubMed
Slopen, N., Kubzansky, L. D., McLaughlin, K. A., & Koenen, K. C. (2013). Childhood adversity and inflammatory processes in youth: A prospective study. Psychoneuroendocrinology, 38, 188–200.CrossRefGoogle ScholarPubMed
Susman, E. J., Dockray, S., Schiefelbein, V. L., Herwehe, S., Heaton, J. A., & Dorn, L. D. (2007). Morningness/eveningness, morning-to-afternoon cortisol ratio, and antisocial behavior problems during puberty. Developmental Psychology, 43, 811–822.CrossRefGoogle ScholarPubMed
Toth, S. L., Maughan, A., Manly, J. T., Spagnola, M., & Cicchetti, D. (2002). The relative efficacy of two interventions in altering maltreated preschool children's representational models: Implications for attachment theory. Development and Psychopathology, 14, 877–908.CrossRefGoogle ScholarPubMed
Tyrka, A. R., Price, L. H., Kao, H. T., Porton, B., Marsella, S. A., & Carpenter, L. L. (2010). Childhood maltreatment and telomere shortening: Preliminary support for an effect of early stress on cellular aging. Biological Psychiatry, 67, 531–534.CrossRefGoogle ScholarPubMed
Wilson, H. W., Widom, C. S. (2011). Pathways from childhood abuse and neglect to HIV-risk sexual behavior in middle adulthood. Journal of Consulting & Clinical Psychology, 79, 236–246.CrossRefGoogle ScholarPubMed
Yaeger, R., Alvial-Bront, A., Abdul, K., Nolan, P. C., Grann, V. R., Birchette, M. G., et al. (2008). Comparing genetic ancestry and self-described race in African Americans born in the United States and in Africa. Cancer Epidemiology, Biomarkers & Prevention, 17, 1329–1338.CrossRefGoogle ScholarPubMed