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Epigenetic pathways through which experiences become linked with biology

Published online by Cambridge University Press:  06 May 2015

Patrick O. McGowan  and
Tania L. Roth
Patrick O. McGowan*
Affiliation:
University of Toronto
Tania L. Roth*
Affiliation:
University of Delaware
*
Address correspondence and reprint requests to: Tania L. Roth, Department of Psychological and Brain Sciences, University of Delaware, 108 Wolf Hall, Newark, DE 19716; E-mail: troth@psych.udel.edu; or Patrick O. McGowan, Department of Biological Sciences, University of Toronto, Scarborough, 1265 Military Trail, Toronto, ON M1C 1A4, Canada; E-mail: patrick.mcgowan@utoronto.ca.
Address correspondence and reprint requests to: Tania L. Roth, Department of Psychological and Brain Sciences, University of Delaware, 108 Wolf Hall, Newark, DE 19716; E-mail: troth@psych.udel.edu; or Patrick O. McGowan, Department of Biological Sciences, University of Toronto, Scarborough, 1265 Military Trail, Toronto, ON M1C 1A4, Canada; E-mail: patrick.mcgowan@utoronto.ca.
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Abstract

This article highlights the defining principles, progress, and future directions in epigenetics research in relation to this Special Issue. Exciting studies in the fields of neuroscience, psychology, and psychiatry have provided new insights into the epigenetic factors (e.g., DNA methylation) that are responsive to environmental input and serve as biological pathways in behavioral development. Here we highlight the experimental evidence, mainly from animal models, that factors such as psychosocial stress and environmental adversity can become encoded within epigenetic factors with functional consequences for brain plasticity and behavior. We also highlight evidence that epigenetic marking of genes in one generation can have consequences for future generations (i.e., inherited), and work with humans linking epigenetics, cognitive dysfunction, and psychiatric disorder. Though epigenetics has offered more of a beginning than an answer to the centuries-old nature–nurture debate, continued research is certain to yield substantial information regarding biological determinants of central nervous system changes and behavior with relevance for the study of developmental psychopathology.

Type
Regular Articles
Information
Development and Psychopathology , Volume 27 , Special Issue 2: Neural Plasticity, Sensitive Periods, and Psychopathology , May 2015 , pp. 637 - 648
Copyright
Copyright © Cambridge University Press 2015 

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