Hostname: page-component-cd9895bd7-8ctnn Total loading time: 0 Render date: 2024-12-23T01:00:56.408Z Has data issue: false hasContentIssue false
  • English
  • Français

Communication deficits in pediatric complex partial seizure disorder and schizophrenia

Published online by Cambridge University Press:  31 October 2008

Rochelle Caplan ,
Donald Guthrie ,
W. Donald Shields  and
Sue Yudovin
Rochelle Caplan*
Affiliation:
Division of Child Psychiatry
Donald Guthrie
Affiliation:
Department of Biostatistics and Mental Retardation Research Center
W. Donald Shields
Affiliation:
Departments of Neurology and Pediatrics
Sue Yudovin
Affiliation:
Departments of Neurology and Pediatrics, University of California, Los Angeles
*
Address correspondence and reprint requests to: Rochelle Caplan, M.D., Neuropsychiatric Institute, 760 Westwood Plaza, Los Angeles, CA 90024.
Get access Rights & Permissions [Opens in a new window]

Abstract

Based on findings that, like schizophrenic children, children with complex partial seizure disorder have illogical thinking, this study examined whether or not these same epileptic subjects had other thought processing impairments found in schizophrenic children. Compared to normal children (N = 38), both the epileptic (N = 27) and schizophrenic children (N = 31) underutilized discourse (cohesive) devices that make speech coherent. The severity of the discourse deficits and formal thought disorder of the schizophrenic children was associated with age, but not with IQ scores. Age, IQ, and seizure-related, not behavioral variables, were associated, however, with the severity of the discourse deficits of the epileptic subjects. The study' findings suggest that measures of impaired thought processing and communication in schizophrenic children could be a model to study the developmental impact of complex partial seizure disorder in middle childhood. The clinical implications of the study's findings are discussed.

Type
Articles
Information
Development and Psychopathology , Volume 6 , Issue 3 , Summer 1994 , pp. 499 - 517
Copyright
Copyright © Cambridge University Press 1994

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Aman, M. G., Werry, J. S., Paxton, J. W., & Turbott, S. H. (1987). Effect of sodium valproate on psychomotor performance in children as a function of dose, fluctuations in concentration, and diagnosis. Epilepsia, 28, 115–124.CrossRefGoogle ScholarPubMed
Aman, M. G., Werry, J. S., Paxton, J. W., Turbott, S. H., & Stewart, A. W. (1990). Effects of carbamazepine on psychomotor performance in children as a function of drug concentration, seizure type, and time of medication. Epilepsia, 31, 51–60.CrossRefGoogle ScholarPubMed
American Psychiatric Association. (1980). Diagnostic and statistical manual of mental disorders (3rd ed.). Washington, DC: Author.Google Scholar
Arboleda, C., & Holzman, P. S. (1985). Thought disorder in children at risk for psychosis. Archives of General Psychiatry, 42, 1004–1013.CrossRefGoogle ScholarPubMed
Beitchman, J. H., Hood, J., & Inglis, A. (1990). Psychiatric risk in children with speech and language disorders. Journal of Abnormal Child Psychology, 18, 283–296.CrossRefGoogle ScholarPubMed
Benson, D. F. (1979). Aphasia, alexia, and agraphia. New York: Churchill Livingstone.Google Scholar
Bourgeois, B. F. D., Prensky, A. L., Palkes, H. S., Talent, B. K., & Busch, S. G. (1983). Intelligence in epilepsy: A prospective study in children. Annals of Neurology, 14, 438–444.CrossRefGoogle ScholarPubMed
Brent, D. A., Crumrine, P. K., Varma, R., Brown, R. V., & Allan, M. J. (1990). Phenobarbital treatment and major depressive disorder in children with epilepsy: A naturalistic follow-up. Pediatrics, 85, 1086–1091.CrossRefGoogle ScholarPubMed
Cantwell, D. P., & Baker, L. (1987). Clinical significance of childhood communication disorders: Perspectives from a longitudinal study. Journal of Child Neurology, 2, 257–264.CrossRefGoogle ScholarPubMed
Caplan, R. (in press). Communication deficits in childhood schizophrenia spectrum disorder. Schizophrenia Bulletin.Google Scholar
Caplan, R., Guthrie, D., Fish, B., Tanguay, P. E., & David-Lando, G. (1989). The Kiddie Formal Thought Disorder Rating Scale (K-FTDS). Clinical assessment, reliability, and validity. Journal of the American Academy of Child and Adolescent Psychiatry, 28, 208–216.Google Scholar
Caplan, R., Guthrie, D., & Foy, J. G. (1992a). Communication deficits and formal thought disorder in schizophrenic children. Journal of the American Academy of Child and Adolescent Psychiatry, 31, 151–159.CrossRefGoogle ScholarPubMed
Caplan, R., Guthrie, D., Shields, W. D., & Mori, L. (1992b). sFormal thought disorder in pediatrie complex partial seizure disorder. Journal of Child Psychology and Psychiatry, 33, 1399–1412.CrossRefGoogle Scholar
Caplan, R., Perdue, S., Tanguay, P. E., & Fish, B. (1990). Formal thought disorder in childhood onset schizophrenia and schizotypal personality disorder. Journal of Child Psychology and Psychiatry and Allied Disorders, 31, 1103–1114.CrossRefGoogle ScholarPubMed
Caplan, R., Shields, W. D., Mori, L., & Yudovin, S. (1991). Middle childhood onset of interictal psychoses: Case studies. Journal of American Academy of Child and Adolescent Psychiatry, 30, 893–896.CrossRefGoogle Scholar
Cohen, N. J., & Lipsett, L. (1987). Recognized and unrecognized language impairment in psychologically disturbed children: Child symptomatology, maternal depression, and family function. Preliminary report. Canadian Journal of Behavioral Science, 23, 376–389.CrossRefGoogle Scholar
Commission on Classification and Terminology of the International League Against Epilepsy. (1989). Proposal for revised clinical and electroencephalo-graphic classification of epileptic seizures. Epilepsia, 30, 389–399.Google Scholar
Csernansky, J. G., Leiderman, D. B., Mandabach, M., & Moses, J. A. Jr. (1990). Psychopathology and limbic epilepsy: Relationship to seizure variables and neuropsychological factors. Epilepsia, 31, 75–280.CrossRefGoogle Scholar
Csernansky, J. G., Mellentin, J., Beauclair, L., & Lombrozo, L. (1988). Mesolimbic dopaminergic supersensitivity following electrical kindling of the amygdala. Biological Psychiatry, 23, 285–924.CrossRefGoogle ScholarPubMed
Ellenberg, J. H., Hirtz, D. G., & Nelson, K. B. (1984). Age of onset of seizures in young children. Annals of Neurology, 15, 127–134.CrossRefGoogle ScholarPubMed
Farwell, J. R., Dodrill, C. B., & Batzel, L. (1985). Neuropsychological abilities of children with epilepsy. Epilepsia, 26, 395–400.CrossRefGoogle ScholarPubMed
Farwell, J. R., Lee, Y. J., Hirtz, D. G., Sulzbacher, S. I., Ellenberg, J. H., & Nelson, K. B. (1990). Phenobarbital for febrile seizures—Effects on intelligence and on seizure recurrence. New England Journal of Medicine, 322, 364–369.CrossRefGoogle ScholarPubMed
Fleiss, J. (1973). Statistical methods for rates and proportions. New York: John Wiley and Sons.Google Scholar
Glaser, G. H. (1987). Natural history of temporal lobe limbic epilepsy. In Engel, J. Jr. (Ed.), Surgical treatment of the epilepsies (pp. 13–30). New York: Raven Press.Google Scholar
Hara, H., & Fukuyama, Y. (1989). Sustained attention during the interictal period of mentally normal children with epilepsy or febrile convulsions, and the influence of anticonvulsants and seizures on attention. Japanese Journal of Psychiatry and Neurology, 43, 411–416.Google ScholarPubMed
Harvey, P. D. (1983). Speech competence in manic and schizophrenic psychoses: The association between clinically rated thought disorder and performance. Journal of Abnormal Psychology, 92, 368–377.CrossRefGoogle Scholar
Herjanic, B., & Campbell, W. (1977). Differentiating psychiatrically disturbed children on the basis of a structured interview. Journal of Abnormal Child Psychology, 5, 127–134.CrossRefGoogle ScholarPubMed
Hermann, B. P. (1982). Neuropsychological functioning and psychopathology in children with epilepsy. Epilepsia, 23, 545–554.CrossRefGoogle ScholarPubMed
Hermann, B. P., Wyler, A. L., Steenman, H., & Richey, E. T. (1988). The interrelationship between language function and verbal learning/memory performance in patients with complex partial seizures. Cortex, 24, 245–253.CrossRefGoogle ScholarPubMed
Herranz, J. L., Armijo, J. A., & Arteaga, R. (1988). Clinical side effects of phenobarbital, primidone, phenytoin, carbamazepine, and valproate during monotherapy in children. Epilepsia, 29, 794–804.CrossRefGoogle ScholarPubMed
Holmes, G. L. (1991). Do seizures cause brain damage? Epilepsia, 32 (Suppl. 5), S14–S22.Google ScholarPubMed
Karmiloff-Smith, A. (1985). Language and cognitive processes from a developmental perspective. Language and Cognitive Processes, 1, 61–85.CrossRefGoogle Scholar
Kauffman, A. S. (1979). Intelligence testing with the WISC-R. New York: Wiley.Google Scholar
Kim, W. J. (1991). Psychiatric aspects of epileptic children and adolescence. Journal of American Academy of Child and Adolescent Psychiatry, 30, 874–886.CrossRefGoogle Scholar
Leaper, C., & Emmory, K. (1985). The discourse of thought disordered schizophrenic children. Brain and Language, 25, 72–86.CrossRefGoogle ScholarPubMed
Liddle, P. F., Friston, K. J., Hirsch, S. R., Jones, T., Frackowiak, R. S. J. (1992). Patterns of cerebral blood flow in schizophrenia. British Journal of Psychiatry, 160, 179–186.CrossRefGoogle ScholarPubMed
Lieb, J. P., Dasheiff, R. M., & Engel, J. Jr. (1991). Role of the frontal lobes in the propagation of mesial temporal lobe seizures. Epilepsia, 32, 822–837.CrossRefGoogle ScholarPubMed
Lindsay, J., Ounsted, C., & Richards, P. (1979). Long-term outcome in children with temporal lobe seizures. III. Psychiatric aspects in childhood and adult life. Developmental Medicine and Child Neurology. 21, 630–636.CrossRefGoogle ScholarPubMed
McTear, M. F. (1985). Children's conversation. Oxford: Basil Blackwell.Google Scholar
Mentis, M., & Prutting, C. A. (1987). Cohesion in the discourse of normal and head-injured adults. Journal of Speech and Hearing Research, 30, 88–98.CrossRefGoogle ScholarPubMed
Mitchell, E. (1979). Interobserver agreement, reliability, and generalizability of data collected in observational studies. Psychology Bulletin, 86, 376–390.CrossRefGoogle Scholar
O'Leary, D. S., Lovell, M. R., Sackellares, C., Berent, S., Giordani, B., Seidenberg, M., & Boll, T. J. (1983). Effects of age of onset of partial and generalized seizures on neuropsychological performance in children. Journal of Nervous and Mental Diseases, 171, 624–629.CrossRefGoogle ScholarPubMed
Perez, M., Trimble, M. R., Murray, N. M. K., & Reider, I. (1985). Epileptic psychoses: An evaluation of PSE profiles. British Journal of Psychiatry, 146, 155–163.CrossRefGoogle ScholarPubMed
Puig-Antich, J., & Chambers, W. (1978). The Schedule for Affective Disorders and Schizophrenia for School-Age Children (Kiddie-SADS). New York: New York State Psychiatric Institute.Google Scholar
Rochester, S. R., & Martin, J. R. (1979). Crazy talk: A study of the discourse of schizophrenic speakers. New York: Plenum Press.CrossRefGoogle Scholar
Rochester, S. R., Martin, J. R., & Thurston, S. (1977). Thought process disorder in schizophrenia: The listener's task. Brain and Language, 4, 95–114.CrossRefGoogle ScholarPubMed
Rodin, E. (1989). Prognosis of cognitive functions in children with epilepsy. In Hermann, B. P. & Seidenberg, M. (Eds.), Childhood epilepsies: Neuropsychological, psychosocial, and intervention aspects (pp. 33–50). New York: John Wiley & Sons.Google Scholar
Russell, A. R., Bott, L., & Sammons, C. (1989). The phenomenology of schizophrenia occurring in childhood. Journal of the American Academy of Child and Adolescent Psychiatry, 28, 399–407.CrossRefGoogle ScholarPubMed
Seidenberg, M. (1989). Academic achievement and school performance of children with epilepsy. In Hermann, B. P. & Seidenberg, M. (Eds.), Childhood epilepsies: Neuropsychological, psychosocial, and intervention aspects (pp. 105–118). New York: John Wiley & Sons.Google Scholar
Shatz, M. (1982). Communication. In Musson, P. (Ed.), Carmichael's manual of child psychology (pp. 841–889). New York: John Wiley and Sons.Google Scholar
Shenton, M. E., Kikinis, R., Jolesz, F. A., Pollak, S. D., LeMay, M., Wible, C. G., Hokama, H., Martin, J., Metcalf, D., Coleman, M., & McCarley, R. W. (1992). Abnormalities of the left temporal lobe and thought disorder in schizophrenia. New England Journal of Medicine, 327, 604–612.CrossRefGoogle ScholarPubMed
Slater, E., & Beard, A. W. (1963). The schizophrenia-like psychoses of epilepsy. British Journal of Psychiatry, 109, 95–150.CrossRefGoogle Scholar
Taylor, D. C., & Marsh, S. M. (1979). The influence of sex and side of operation on personality questionnaire responses after temporal lobectomy. In Gruzelier, H. & Flor-Henry, P. (Eds.), Hemisphere asymmetries of function in psychopathology (pp. 391–400). Development and Psychiatry Series. Amsterdam: Elsevier.Google Scholar
Trimble, M. R., & Cull, C. A. (1987). Antiepileptic drugs, cognitive function, and behavior in children. Cleveland Journal of Medicine, 56 (Suppl. Part 1), S-140–S-146.Google Scholar
Vining, E. P. G., Mellitis, D., Dorsen, M. M., Cataldo, M. F., Quaskey, S. A., Spielberg, S. P., & Freeman, J. M. (1987). Psychological and behavioral effects of antiepileptic drugs in children: A double-blind comparison between phenobarbital and valproic acid. Pediatrics, 80, 165–174.CrossRefGoogle ScholarPubMed