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XV.—Strophanthus sarmentosus: its Pharmacological Action and its use as an Arrow-poison.

Published online by Cambridge University Press:  06 July 2012

Thomas R. Fraser
Affiliation:
Professor of Materia Medica in theUniversity of Edinburgh
Alister T. Mackenzie
Affiliation:
Carnegie Research Scholar

Extract

In the course of an endeavour, which was successful only after a number of years, to obtain specimens for the purpose of identifying the species of Strophanthus that produces the smooth seeds which had been chemically and pharmacologically investigated by one of us several years ago, the follicles, flowers and other parts of a number of different species of Strophanthus were obtained from Africa. Among them, S. sarmentosus was represented, and in the course of time a sufficient quantity of seeds of this plant was collected to allow an examination to be undertaken of their chemistry and pharmacology.

Type
Research Article
Copyright
Copyright © Royal Society of Edinburgh 1910

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References

page 342 note * Payrau, , Recherches sur les Strophanthus, 1900, p. 86.Google Scholar

page 342 note † Stapf, , Flora of Tropical Africa, vol. iv., 1904, p. 180.Google Scholar

page 342 note ‡ Payrau, loc. cit., p. 86.

page 343 note * A few of the seeds that had protruded to the outside of opened-up follicles, and many of the seeds that had been removed from the follicles and dried in Africa, are of a very pale fawn or deep cream colour, having become blanched, apparently, by exposure to weather.

page 343 note † On submitting seeds to Mr HOLMES, of the Pharmaceutical Society of Great Britain, who originated this test and has applied it to the seeds of many species of Strophanthus, he states that he obtained very similar colour-changes, and he expresses the opinion “that there can be no doubt, therefore, that your seeds are those of Strophanthus sarmentosus.”

page 344 note * Transactions of the Royal Society of Edinburgh, vol. xxxv., part iv., 1890, pp. 1001–3.

page 344 note ‡ Some of these seeds were secured by Dr DALZIEL, and on examination were found to be seeds of S. sarmentosus.

page 349 note * In the case of warm-blooded animals—rats, rabbits and cats—the weight was taken and the extract was administered always at the end of the same interval of time (18 hours) subsequent to the last reception of food, in order to eliminate, as far as possible, variations in weight due to differences in the amount of the contents of the alimentary canal.

page 351 note * The extract of S. sarmentosus used in these experiments is thus shown to possess only one-fifth of the lethal power in frogs and one-half in rabhits of the similarly prepared extract of S. hispidus which was used in the experiments with the latter substance made by one of us (Trans. R.S.E., vols. xxxv, and xxxvi., 1890 and 1891).

page 352 note † In this and in the other sections of the investigation, several other experiments were made, which gave results concording with those in the experiments that have been recorded.

page 396 note * In this and the following experiment, Merek's “Digitalin pur. pulv.” was used. Its minimum-lethal dose for frogs was found to be 0·045 gram per kilo., or thirteen times larger than that of the extract of S. sarmentosus (0·0035 gram per kilo.) used in our experiments.