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Genotyping of hepatitis C virus isolates from Basque Country, Spain

Published online by Cambridge University Press:  15 May 2009

G. Cilla ,
M. García-Bengoechea ,
E. Perez Trallero ,
I. Montalvo ,
D. Vicente  and
J. I. Arenas
G. Cilla
Affiliation:
Microbiology Service and Infectious Epidemiology Unit
M. García-Bengoechea
Affiliation:
Department of Gastroenterology, Hospital Nuestra Señora de Aránzazu, Apartado de Correos 477, 20080 San Sebastián, Spain
I. Montalvo
Affiliation:
Department of Gastroenterology, Hospital Nuestra Señora de Aránzazu, Apartado de Correos 477, 20080 San Sebastián, Spain
D. Vicente
Affiliation:
Microbiology Service and Infectious Epidemiology Unit
J. I. Arenas
Affiliation:
Department of Gastroenterology, Hospital Nuestra Señora de Aránzazu, Apartado de Correos 477, 20080 San Sebastián, Spain
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The genotype of HCV was determined in 161 chronic HCV-infected patients. The patients were classified into three groups on the basis of the origin of the HCV infection: 50 patients had a history of intravenous drug use (IVDU) but no HIV infection; 41 patients had received blood transfusions, and 70 patients had no known exposure. The distribution of HCV genotypes was associated with the origin of infection and age of patients: genotype 1b was predominant among patients who had received blood transfusions and those without evidence of parenteral exposure (84·6% and 67·7%, respectively), whereas genotype 3a was present in 65·3% of IVDUs. Patients with genotype 1b were older than those with genotypes la or 3a: 50·3 ± 12 vs. 34·1±9·9 and 31 ± 5.4 years, respectively. These findings suggest that the pattern of HCV genotypes in our region is changing and that genotype 1b may be substituted by 3a as the dominant genotype in the future.

Type
Research Article
Information
Epidemiology & Infection , Volume 117 , Issue 3 , December 1996 , pp. 533 - 536
Copyright
Copyright © Cambridge University Press 1996

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