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Glycine and formic hydrogenlyase

Published online by Cambridge University Press:  15 May 2009

J. Gordon
Affiliation:
From the Department of Pathology and Bacteriology and the Department of Experimental Pathology and Cancer Research, University of Leeds
L. H. Stickland
Affiliation:
From the Department of Pathology and Bacteriology and the Department of Experimental Pathology and Cancer Research, University of Leeds
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1. A strain of Boot, coli adapted to growth in high glycine concentrations, which had lost the power of producing ‘gas’ from sugars, was shown to be devoid of formic hydrogenlyase.

2. Formic acid was prominent among the products of fermentation of sugars by this strain.

3. The appearance of formic hydrogenlyase in vitro, in bacteria grown in such a way as not to contain the enzyme, was inhibited by glycine at high concentrations.

One of us (J. G.) is indebted to the Medical Research Council for a grant-in-aid for expenses.

Type
Research Article
Copyright
Copyright © Cambridge University Press 1949

References

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Stephenson, M. & Stickland, L. H. (1933). Biochem. J. 27, 1528.CrossRefGoogle Scholar