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The inhibition of growth of vaccinia and cowpox viruses in RK 13 cells

Published online by Cambridge University Press:  15 May 2009

Derrick Baxby  and
C. J. M. Rondle
Derrick Baxby
Affiliation:
Department of Bacteriology, Liverpool University, Liverpool 3, England
C. J. M. Rondle
Affiliation:
Department of Bacteriology, Liverpool University, Liverpool 3, England
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The growth of vaccinia and cowpox in RK13 cells was studied by measurement of infective virus production, gel diffusion and haemagglutination. The effects of virus growth inhibitors on the normal course of infection were then followed. Although the results with the two viruses were essentially similar some differences were detected between them. Inhibitors of DNA synthesis permitted production of many virus-specific soluble antigens. Compounds which inhibit DNA function and compounds that affected energy-yielding reactions had more dramatic effects. The different results obtained suggested that the synthesis of virus-specific materials was sequential and a possible part of the sequence is suggested.

Type
Original Articles
Information
Journal of Hygiene , Volume 66 , Issue 2 , June 1968 , pp. 191 - 205
Copyright
Copyright © Cambridge University Press 1968

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