Hostname: page-component-78c5997874-dh8gc Total loading time: 0 Render date: 2024-11-19T13:40:31.558Z Has data issue: false hasContentIssue false
  • English
  • Français

Laboratory studies on a strain of Asian influenza virus used as a living vaccine. (A report to the Medical Research Council Committee on Influenza and other Respiratory Virus Vaccines*)

Published online by Cambridge University Press:  15 May 2009

D. Hobson ,
E. A. Gould  and
Hilary I. Flockton
D. Hobson
Affiliation:
The Department of Bacteriology, University of Liverpool
E. A. Gould
Affiliation:
The Department of Bacteriology, University of Liverpool
Hilary I. Flockton
Affiliation:
The Department of Bacteriology, University of Liverpool
Rights & Permissions [Opens in a new window]

Extract

Core share and HTML view are not available for this content. However, as you have access to this content, a full PDF is available via the ‘Save PDF’ action button.

Two pools of living influenza vaccine derived from the Russian A 2 strain Iksha had given discrepant results in clinical trials. The less effective pool showed an increased thermostability of haemagglutinin, an increased elution rate from red blood cells and a reduced ability to grow in chorioallantoic membranes at temperatures above 40° C. The relationship of these findings to the virulence of influenza viruses is discussed.

Type
Research Article
Information
Journal of Hygiene , Volume 65 , Issue 2 , June 1967 , pp. 255 - 262
Copyright
Copyright © Cambridge University Press 1967

References

Alexandrova, G. I. & Smorodintsev, A. A. (1965). Obtaining of an additionally attenuated vaccinating cryophil influenza strain. Rev. roum. Inframicrobiol. 2, 179.Google Scholar
Andrews, B. E., Beare, A. S., McDonald, J. C., Zuckermann, A. J. & Tyrrell, D. A. J. (1966). Further trials of live influenza vaccine. Br. med. J. i, 637.CrossRefGoogle Scholar
Beare, A. S., Tyrrell, D. A. J., McDonald, J. C., Pollock, T. M., Taylor, C. E. D., Howells, C. H. L. & Tyler, L. E. (1967). Reactions and antibody response to live influenza vaccine prepared from the Iksha (A 2) strain. J. Hyg., Camb. 65, 245.CrossRefGoogle Scholar
Bedson, H. S. & Dumbell, K. R. (1961). The effect of temperature on the growth of pox viruses in chick embryo. J. Hyg., Camb. 59, 457.Google ScholarPubMed
Bedson, H. S. & Dumbell, K. R. (1964). Hybrids derived from viruses of alastrim and rabbit pox. J. Hyg., Camb. 62, 141.CrossRefGoogle ScholarPubMed
Burnet, F. M. (1951). A genetic approach to variation in influenza viruses. 1. The characters of three substrains of influenza virus A (WS). J. gen. Microbiol. 5, 46.CrossRefGoogle ScholarPubMed
Daniels, J. B., Eaton, M. D. & Perry, M. E. (1952). Effect of glucose on the growth of influenza virus in deembryonated eggs and tissue cultures. J. Immun. 69, 321.CrossRefGoogle ScholarPubMed
Dubes, G. R. & Wenner, H. A. (1957). Virulence of polioviruses in relation to variant characteristics distinguishable on cells in vitro. Virology 4, 275.CrossRefGoogle ScholarPubMed
Eaton, M. D., Adler, L. T. & Perry, M. E. (1953). Virus growth and cellular energy production: effect of substances chemically related to thyroxin on influenza virus. Proc. Soc. exp. Biol. Med. 84, 57.CrossRefGoogle ScholarPubMed
Fazekas de st Groth, S. & White, D. O. (1958). An improved assay for the infectivity of influenza viruses. J. Hyg., Camb. 56, 151.CrossRefGoogle ScholarPubMed
Hobson, D. (1966). The strain-specific serological activity of a non-haemagglutinating fraction of influenza viruses. Br. J. exp. Path. 47, 257.Google Scholar
Levene, A. S., Bond, P. H. & Rouse, H. C. (1956). Modification of viral synthesis in tissue culture by substituting pyruvate for glucose in the medium. Proc. Soc. exp. Biol. Med. 93, 233.CrossRefGoogle Scholar
Lief, F. S. & Henle, W. (1956). Studies on the soluble antigen of influenza virus. II. A comparison of the effects of sonic vibration and ether treatment of elementary bodies. Virology 2, 772.CrossRefGoogle Scholar
Lindenmann, J., Lane, C. A. & Hosson, D. (1963). The resistance of A2G mice to myxoviruses. J. Immun. 90, 942.CrossRefGoogle ScholarPubMed
McDonald, J. C., Zuckermann, A. J., Beare, A. S. & Tyrrell, D. A. J. (1962). Trials of live influenza vaccine in the Royal Air Force. A Report to the Medical Research Council Committee on Influenza and Other Respiratory Virus Vaccines. Br. med. J. i, 1036.CrossRefGoogle Scholar
Soloviev, V. D., Orlova, T. G., Porubel, L. A. & Vasilieva, I. N. (1961). Study of the genetic characters of vaccine strains of type A-2 influenza virus. Vop. virus 6, 684.Google Scholar
Veeraraghavan, N., Kirtikar, M. W. & Sreevalsan, T. (1961). Studies on the cultivation of influenza virus in vitro. Bull. Wld Hlth Org. 24, 711.Google ScholarPubMed
World Health Organization Expert Committee on Influenza. (1953). Tech. Rep. Ser. Wld Hlth Org. no. 64.Google Scholar