Hostname: page-component-586b7cd67f-t7czq Total loading time: 0 Render date: 2024-11-21T15:47:43.575Z Has data issue: false hasContentIssue false
  • English
  • Français

A possible relation between human pathogenicity of smallpox vaccines and virus growth at elevated temperatures

Published online by Cambridge University Press:  15 May 2009

Derrick Baxby
Derrick Baxby
Affiliation:
Department of Medical Microbiology, University of Liverpool, New Medical School, P.O. Box 147, Liverpool L 69 3BX
Rights & Permissions [Opens in a new window]

Summary

Core share and HTML view are not available for this content. However, as you have access to this content, a full PDF is available via the ‘Save PDF’ action button.

Seven smallpox vaccines of known human pathogenicity were tested for their ability to produce pocks on the chick chorioallantois at 39·7° C. Significant differences were found and the more pathogenic strains produced pocks with greater efficiency at 39·7° C. than did strains of average or low pathogenicity.

Type
Research Article
Information
Journal of Hygiene , Volume 73 , Issue 1 , August 1974 , pp. 35 - 38
Copyright
Copyright © Cambridge University Press 1974

References

REFERENCES

Anderson, E. K. (1969). Selection of a strain of vaccinia virus for production of smallpox vaccine. Proceedings of a Symposium on Smallpox, pp. 53–64. Yugoslav Academy of Sciences and Arts, Zagreb.Google Scholar
Baxby, D. (1969). Variability in the pocks produced on the chick chorioallantois by white pock mutants of cowpox and other poxviruses. Journal of Hygiene 67, 637–47.Google Scholar
Bedson, H. S. & Dumbell, K. R. (1961). The effect of temperature on the growth of poxviruses in the chick embryo. Journal of Hygiene 59, 457–69.Google ScholarPubMed
Bedson, H. S., Dumbell, K. R. & Thomas, W. R. G. (1963). Variola in Tanganyika. Lancet ii, 1085–8.Google Scholar
Bektemikov, T. A., Shenkman, L. S. & Marennikova, S. S. (1971). Interfering capacity of vaccinia virus strains of different pathogenicity. Voprosy virusologii No. 16, 555–60. (In Russian.)Google Scholar
Ducksbury, C. F. J., Elliot, A., Hutchinson, R., Lee, A. J., McCallum, D. I., McDonald, J. R., Parry, W. H., Pereira, M. A. & Pollock, T. M. (1972). Smallpox vaccination of normal and eczematous children with the attenuated CV1–78 strain of vaccinia virus. Community Medicine 127, 155–7.Google Scholar
John, T. J. (1969). Properties of the CV-1 strain of vaccinia virus. 11. Studies in eggs and mice. Archiv für die gesamte Virusforschung 26, 366–70.Google Scholar
Kempe, C. H. (1968). Smallpox vaccination of eczema patients with attenuated live vaccinia virus. Yale Journal of Biology and Medicine 41, 1–12.Google Scholar
Marennikova, S. S., Chimishyan, K. L., Maltseva, N. N., Shelukhina, E. M. & Fedorov, V. V. (1969). Characteristics of virus strains for production of smallpox vaccine. Proceedings of a Symposium on Smallpox, pp. 65–79. Yugoslav Academy of Sciences and Arts, Zagreb.Google Scholar
Nizamuddin, M. & Dumbell, K. R. (1961). A simple test to distinguish the virus of smallpox from that of alastrim. Lancet i, 68–9.Google Scholar
Polak, M. F., Beunders, B. J. W., Van der Werff, A. R., Sanders, E. W., Van Klaveren, J. N. & Brans, L. M. (1963). A comparative study of clinical reaction observed after application of several smallpox vaccines in primary vaccinations of young adults. Bulletin of the World Health Organization 29, 311–22.Google ScholarPubMed
Turner, G. S. (1967). Respiratory infection of mice with vaccinia virus. Journal of General Virology 1, 399–402.Google Scholar