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Respiratory and humoral immune response to aerosol and intramuscular pertussis vaccine

Published online by Cambridge University Press:  15 May 2009

Gerald Thomas
Gerald Thomas
Affiliation:
Essex Chemie AG, Töpferstrasse 5, 6004 Lucerne, Switzerland
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Summary

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Animal experiments have shown that respiratory administration of pertussis antigen induces a protective immune response. In this study pertussis antibody in human respiratory secretions was measured and the response to aerosol and intramuscular pertussis immunization investigated. Substantial increases in this antibody occurred after aerosol immunization but no changes were found in serum antibody. The reverse was observed after intramuscular immunization. Severe side effects are frequently seen after intramuscular pertussis vaccine in adults but not with aerosol immunization. The latter method may be of value for paediatric medical and nursing personnel exposed to the risk of pertussis infection.

Type
Research Article
Information
Journal of Hygiene , Volume 74 , Issue 2 , April 1975 , pp. 233 - 237
Copyright
Copyright © Cambridge University Press 1975

References

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