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Sero-epidemiological study of reovirus infection amongst the normal population of the Chandigarh area—northern India

Published online by Cambridge University Press:  15 May 2009

S. R. Pal  and
S. C. Agarwal
S. R. Pal
Affiliation:
Department of Microbiology, Post-Graduate Institute of Medical Education and Research, Chandigarh, India
S. C. Agarwal
Affiliation:
Department of Microbiology, Post-Graduate Institute of Medical Education and Research, Chandigarh, India
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Two hundred and sixty-four samples of sera obtained from normal healthy persons belonging to different age groups were examined for haemagglutination-inhibiting antibodies against reovirus types 1–3 to assess the prevalence of reovirus infection in the northern part of India.

Reovirus infection appeared as early as 6 months to 1 year of age. With reovirus types 1 and 2, the maximum incidence of 67 and 48% respectively occurred by the age of 10–20 years, whereas with type 3 infection the maximum incidence (73%) was reached by the age of 25 years. The incidence of reovirus type 2 infection in all the age groups was remarkably low in this series. A drop in the incidence of reovirus type 2 infection was also noticed after the age of 20 years.

The difference in geometric mean titre of antibody in different ages against reovirus type 2 was highly significant, suggesting probably that most of the infection occurred by the age of twenty years. The difference in the geometric mean value of the titres of antibody against types 1 and 3 was not significant in different age groups. The levels of antibody against types 1 and 3 in all the age groups were almost the same, suggesting that infection, specially with reovirus type 3, was occurring in all the age groups even beyond 20 years of age.

The authors wish to express their sincerest thanks to Dr Leon Rosen, Pacific Research Section, National Institute of Allergy and Infectious Diseases, Honolulu, Hawaii, for the supply of prototype strains of reoviruses, to Drs B. K. Aikat, Director Professor of Pathology, R. N. Chakravarti, Department of Experimental Medicine, O. N. Bhakoo, and Sucheta Thukral, Department of Paediatrics, Post- Graduate Institute of Medical Education and Research, Chadigarh, for their invaluable help and co-operation, to Prof. P. V. K. Iyer, Department of Mathematics, Panjab University, and to Mr H. D. Gupta, Biostatistician, Post-Graduate Institute of Medical Education and Research, Chadigarh for their statistical analysis of the results.

The authors gratefully acknowledge the helpful criticism and suggestion of Dr C G. Pandit, Ex-Director, Indian Council of Medical Research, during the preparation of the paper.

The authors acknowledge also the technical assistance of Mr Jagmohan Lai Pipat, Mr Gurmeet Singh Khatra, and Mr Amar Singh Saini.

This work was partly supported by the Research Grant of the Indian Council of Medical Research sanctioned to one of the authors (S. R. P.).

Type
Research Article
Information
Journal of Hygiene , Volume 66 , Issue 4 , December 1968 , pp. 519 - 529
Copyright
Copyright © Cambridge University Press 1968

References

REFERENCES

Brown, P. K. & Taylor-Robinson, D. (1966). Respiratory virus antibodies in sera of persons living in isolated communities. Bull. Wld Hlth Org. 34, 895.Google ScholarPubMed
Jackson, G. G., Muldoon, R. L. & Cooper, G. S. (1961). Reovirus Type 1 as an etiologic agent of the common cold. J. clin. Invest. 40, 1051.Google Scholar
Joske, R. A., Keall, D. D., Leak, P. J., Stanley, N. F. & Walters, M. N. I. (1964). Hepatitis-encephalitis in humans with reovirus infection. Archs intern. Med. 113, 811.CrossRefGoogle ScholarPubMed
Lerner, A. M. (1963). Discussion in the conference on newer respiratory disease viruses. Am. Rev. resp. Dis. 88 (suppl.), 300.Google Scholar
Lerner, A. M., Cherry, J. D., Klein, J. O. & Finland, M. (1962). Infections with reoviruses. New Engl. J. Med. 267, 947.CrossRefGoogle ScholarPubMed
Pal, S. R., Banerjea, G. & Aikat, B. K. (1966). Serological investigation on endemicity of poliomyelitis in Calcutta and in a neighbouring rural area. Indian J. med. Res. 54, 507.Google Scholar
Ramos-Alvarez, M. & Sabin, A. B. (1956). Intestinal viral flora of healthy children demonstrable by monkey kidney tissue culture. Am. J. publ. Hlth 46, 295.CrossRefGoogle ScholarPubMed
Ramos-Alvarez, M. & Sabin, A. B. (1958). Entero-pathogenic viruses and bacteria: role in summer diarrhoeal diseases of infancy and early childhood. J. Am. med. Ass. 167, 147.CrossRefGoogle Scholar
Rosen, L. (1964). Diagnostic procedures for viral and rickettsial disease. Ed. Lennette, E. H. & Smidt, N. J., 3rd ed. p. 259. American Public Health Association.Google Scholar
Rosen, L., Hovis, J. F., Mastrota, F. M., Bell, J. A. & Huebner, R. J. (1960 a). An outbreak of infection with Type 1 reovirus among children in an institution. Am. J. Hyg. 71, 266.Google Scholar
Rosen, L., Hovis, J. F., Mastrota, F. M., Bell, J. A. & Huebner, R. J. (1960 b). Observations on a newly recognized virus (Abney) of the reovirus family. Am. J. Hyg. 71, 258.Google ScholarPubMed
Sabin, A. B. (1956). The significance of viruses recovered from the intestinal tracts of healthy infants and children. Ann. N.Y. Acad. Sci. 66, 226.CrossRefGoogle ScholarPubMed
Sabin, A. B. (1959). Reoviruses. Science, N. Y. 130, 1387.CrossRefGoogle ScholarPubMed
Schmidt, J., Tauchnitz, C. & Kuhn, O. (1965). Untersuchungen über das Vorkommen hämagglutinationshemmender Antikörper gegen die Reovirustypen 1 und 2 in der Bevölkerung. Z. Hyg. InfektKrankh. 150, 269.CrossRefGoogle Scholar
Taylor-Robinson, D. (1963). Laboratory and volunteer studies on some viruses isolated from common colds (Rhinoviruses). Am. Rev. resp. Dis. 88 (suppl.), p. 262.Google ScholarPubMed
Taylor-Robinson, D. (1965). Respiratory virus antibodies in human sera from different regions of the world. Bull. Wld Hlth Org. 32, 833.Google ScholarPubMed