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The Spread of Bacterial Infection1. The Potential Infectivity of a Surviving Mouse-Population, and their Resistance to Subsequent Epidemics of the Same Disease

Published online by Cambridge University Press:  15 May 2009

W. W. C. Topley
Affiliation:
Director of Institute of Pathology, Charing Cross Hospital.
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In a previous communication (1921) experiments have been described showing the effect produced by continuously adding normal mice to a cage, the population of which is infected with bacilli of the group which includes B. gaertner and B. suipestifer. It was seen that under these circumstances the spread of infection progresses in a series of epidemic waves, and that the survival-time of any batch of mice varies according to the period at which they are introduced to the cage. It was further shown that, if such regular and continuous addition of susceptible animals be persisted in over long periods of time, all the micewill eventually succumb, while, if the addition of new individuals be discontinued, the epidemic will eventually subside, leaving a proportion of survivors who may remain in apparently good health over a considerable period.

Type
Research Article
Copyright
Copyright © Cambridge University Press 1921

References

REFERENCES

Hirsch, A. (1883). Handbook of Geographical and Historical Pathology, II. 31. (English translation, New Syd. Soc. Lond.)Google Scholar
Topley, W.W.C. (1919). The Spread of Bacterial Infection. Lancet, II. 1, etc.CrossRefGoogle Scholar
Topley, W.W.C. (1921). The Spread of Bacterial Infection. Some characteristics of long-continued epidemics. Journ. Of Hyg. XIX. 350.Google Scholar