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Studies on the effect of penicillin upon Gram-negative bacteria. Penicillin-sulphonamide synergy

Published online by Cambridge University Press:  15 May 2009

G. T. Stewart
G. T. Stewart
Affiliation:
From the City Hospital Laboratory, Aberdeen
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The effect of penicillin alone, and with sulphonamide upon various Gram-negative bacteria, has been investigated.

S. typhi, S. paratyphi B and strains of Proteus vulgaris were inhibited by penicillin in concentrations of 8–20 units/c.c. Certain coliforms were inhibited by 30–128 units.

Organisms which were inhibited to some extent by penicillin and sulphonamide acting separately were inhibited under experimental conditions at lower concentrations when both agents acted together. The mechanism of this reaction has been discussed.

A proportion of the insensitive coliform strains were identified as penicillinase producers.

Type
Research Article
Information
Journal of Hygiene , Volume 45 , Issue 3 , August 1947 , pp. 282 - 289
Copyright
Copyright © Cambridge University Press 1947

References

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