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Psychosis Incident Cohort Outcome Study (PICOS). A multisite study of clinical, social and biological characteristics, patterns of care and predictors of outcome in first-episode psychosis. Background, methodology and overview of the patient sample

Published online by Cambridge University Press:  15 June 2012

A. Lasalvia ,
S. Tosato ,
P. Brambilla ,
M. Bertani ,
C. Bonetto ,
D. Cristofalo ,
S. Bissoli ,
K. De Santi ,
L. Lazzarotto  and
G. Zanatta
...Show all authors
A. Lasalvia*
Affiliation:
Department of Public Health and Community Medicine, Section of Psychiatry, University of Verona, Verona, Italy
S. Tosato
Affiliation:
Department of Public Health and Community Medicine, Section of Psychiatry, University of Verona, Verona, Italy
P. Brambilla
Affiliation:
DISM, Inter-University Centre for Behavioural Neurosciences, University of Udine, Udine, Italy and Scientific Institute IRCCS ‘E. Medea’, Udine, Italy
M. Bertani
Affiliation:
Department of Public Health and Community Medicine, Section of Psychiatry, University of Verona, Verona, Italy
C. Bonetto
Affiliation:
Department of Public Health and Community Medicine, Section of Psychiatry, University of Verona, Verona, Italy
D. Cristofalo
Affiliation:
Department of Public Health and Community Medicine, Section of Psychiatry, University of Verona, Verona, Italy
S. Bissoli
Affiliation:
Department of Public Health and Community Medicine, Section of Psychiatry, University of Verona, Verona, Italy
K. De Santi
Affiliation:
Department of Public Health and Community Medicine, Section of Psychiatry, University of Verona, Verona, Italy
L. Lazzarotto
Affiliation:
Department of Public Health and Community Medicine, Section of Psychiatry, University of Verona, Verona, Italy
G. Zanatta
Affiliation:
Department of Public Health and Community Medicine, Section of Psychiatry, University of Verona, Verona, Italy
G. Marrella
Affiliation:
Department of Public Health and Community Medicine, Section of Psychiatry, University of Verona, Verona, Italy
R. Mazzoncini
Affiliation:
Department of Public Health and Community Medicine, Section of Psychiatry, University of Verona, Verona, Italy
M. Zanoni
Affiliation:
Department of Public Health and Community Medicine, Section of Psychiatry, University of Verona, Verona, Italy
N. Garzotto
Affiliation:
Department of Mental Health, 1st Psychiatric Service, ULSS 20, Verona, Italy
C. Dolce
Affiliation:
Department of Mental Health, ULSS 6, Vicenza, Italy
S. Nicolau
Affiliation:
Department of Mental Health, ULSS 22, Isola d/S, VR, Italy
L. Ramon
Affiliation:
Department of Mental Health, ULSS 10, Portogruaro, VE, Italy
C. Perlini
Affiliation:
Department of Public Health and Community Medicine, Section of Psychiatry and Inter-University Centre for Behavioural Neurosciences University of Verona, Verona, Italy
G. Rambaldelli
Affiliation:
Department of Public Health and Community Medicine, Section of Psychiatry and Inter-University Centre for Behavioural Neurosciences University of Verona, Verona, Italy
M. Bellani
Affiliation:
Department of Public Health and Community Medicine, Section of Psychiatry and Inter-University Centre for Behavioural Neurosciences University of Verona, Verona, Italy
M. Tansella
Affiliation:
Department of Public Health and Community Medicine, Section of Psychiatry, University of Verona, Verona, Italy
M. Ruggeri
Affiliation:
Department of Public Health and Community Medicine, Section of Psychiatry, University of Verona, Verona, Italy
*
*Address for correspondence: Dr Antonio Lasalvia, Department of Public Health and Community Medicine, Section of Psychiatry, University of Verona, Policlinico ‘G.B. Rossi’, Piazzale L. A. Scuro 10, 37134-Verona, Italy. (Email: antonio.lasalvia@univr.it)
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Abstract

Aims.

This paper aims at providing an overview of the background, design and initial findings of Psychosis Incident Cohort Outcome Study (PICOS).

Methods.

PICOS is a large multi-site population-based study on first-episode psychosis (FEP) patients attending public mental health services in the Veneto region (Italy) over a 3-year period. PICOS has a naturalistic longitudinal design and it includes three different modules addressing, respectively, clinical and social variables, genetics and brain imaging. Its primary aims are to characterize FEP patients in terms of clinical, psychological and social presentation, and to investigate the relative weight of clinical, environmental and biological factors (i.e. genetics and brain structure/functioning) in predicting the outcome of FEP.

Results.

An in-depth description of the research methodology is given first. Details on recruitment phase and baseline and follow-up evaluations are then provided. Initial findings relating to patients' baseline assessments are also presented. Future planned analyses are outlined.

Conclusions.

Both strengths and limitations of PICOS are discussed in the light of issues not addressed in the current literature on FEP. This study aims at making a substantial contribution to research on FEP patients. It is hoped that the research strategies adopted in PICOS will enhance the convergence of methodologies in ongoing and future studies on FEP.

Keywords

First-episode psychosisoutcomefollow-up studygeneticspredictorsbrain imaging
Type
Original Articles
Information
Epidemiology and Psychiatric Sciences , Volume 21 , Issue 3 , September 2012 , pp. 281 - 303
Copyright
Copyright © Cambridge University Press 2012

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