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Comparisons of analgesic effects of different doses of morphine and morphine plus methylprednisolone after knee surgery

Published online by Cambridge University Press:  28 July 2005

M. Kizilkaya ,
O. S. Yildirim ,
N. Ezirmik ,
H. Kursad  and
O. Karsan
M. Kizilkaya
Affiliation:
Atatürk University, The School of Medicine, Departments of Anesthesiology and Reanimation, Erzurum, Turkey
O. S. Yildirim
Affiliation:
Atatürk University, The School of Medicine, Department of Orthopaedic Surgery, Erzurum, Turkey
N. Ezirmik
Affiliation:
Atatürk University, The School of Medicine, Department of Orthopaedic Surgery, Erzurum, Turkey
H. Kursad
Affiliation:
Atatürk University, The School of Medicine, Departments of Anesthesiology and Reanimation, Erzurum, Turkey
O. Karsan
Affiliation:
Atatürk University, The School of Medicine, Department of Orthopaedic Surgery, Erzurum, Turkey
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Extract

Summary

Background: In this double-blind randomized study, the analgesic effects of morphine alone and with methylprednisolone were examined in 72 patients undergoing arthroscopic knee surgery. Methods: At the end of arthroscopy, patients were allocated randomly to one of four groups to receive intra-articular administrations of saline, morphine 1 mg, morphine 5 mg or morphine 1 mg with methylprednisolone 40 mg. Preoperative and postoperative pain levels at rest and during movement (active flexion of the knee) were measured by a visual analogue scale (VAS). Postoperative analgesic requirements to alleviate pain were evaluated. Results: Pain scores were significantly lower for the patients who received 5 mg morphine and 1 mg morphine with 40 mg methylprednisolone than for those who received saline or 1 mg morphine. This was accompanied by a decrease in the postoperative consumption of analgesics and prolongation of the duration of pain relief. Conclusions: This study confirms that the analgesic effect of morphine given intra-articularly is dose dependent and that combination of methylprednisolone with morphine has an additive effect on analgesia.

Keywords

MORPHINEMETHYLPREDNISOLONEORTHOPAEDIC SURGERY, kneeINJECTIONS, INTRA-ARTICULARPOSTOPERATIVE PERIODPAIN, POSTOPERATIVE
Type
Original Article
Information
European Journal of Anaesthesiology , Volume 22 , Issue 8 , August 2005 , pp. 603 - 608
Copyright
© 2005 European Society of Anaesthesiology

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