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Factores que influyen en la investigación de los criterios de valoración de la depresión (FINDER): Diseño del studio y características de la población

Published online by Cambridge University Press:  01 May 2008

Ana García-Cebriár ,
Michael Bauerb ,
Angel L. Montejo ,
Nicolás Dantchev ,
Koen Demyttenaere ,
Paul Gandhi ,
Luigi Grassi ,
Brigitta U. Monz ,
David G.S. Perahia  and
Deborah Quail
...Show all authors
Ana García-Cebriár
Affiliation:
Eli Lilly and Company, Centro de Investigación Lilly, Wood Manor, Sunninhill Road, Windlesham, Surrey GU20 6PH, Reino Unido
Michael Bauerb
Affiliation:
Departamento de Psiquiatría y Psicoterapia, Hospital Universitario Carl Gnstav Carus, Technische Universität Dresde, Fetscherstrabe 4, D 01307Dresde, Alemania
Angel L. Montejo
Affiliation:
Hospital Universitario de Salamanca, Avda. Comuneros 27, Salamanca37003, España
Nicolás Dantchev
Affiliation:
Unidad de Psiquiatría, Hótel-Dieu, 1 Place du Parvis Notre Dame, 75004París, Francia
Koen Demyttenaere
Affiliation:
Universitair Ziekenhuis Gasthuisberg Herestraat 49, 3000Leuven, Bélgica
Paul Gandhi
Affiliation:
Eli Lilly and Company, Centro de Investigación Lilly, Wood Manor, Sunninhill Road, Windlesham, Surrey GU20 6PH, Reino Unido
Luigi Grassi
Affiliation:
Universidad de Ferrara, Corso Giovecca 203, 44100Ferrara, Italia
Brigitta U. Monz
Affiliation:
Boehringer Ingelheim GmbH, D 55216Ingelheim, Alemania
David G.S. Perahia
Affiliation:
Eli Lilly and Company, Centro de Investigación Lilly, Wood Manor, Sunninhill Road, Windlesham, Surrey GU20 6PH, Reino Unido Hospital Gordon, Bloomburg Street, Londres SWIV 2RH, Reino Unido
Deborah Quail
Affiliation:
Eli Lilly and Company, Centro de Investigación Lilly, Wood Manor, Sunninhill Road, Windlesham, Surrey GU20 6PH, Reino Unido
Andre Tylee
Affiliation:
Sección de Salud Mental de Atención Primaria, Departamento de Investigación de la Población y Senecios Sociales, Instituto de Psiquiatría, Parque De Crespigny, Denmark Hill, Londres SE5 8AF, Reino Unido
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Resumen

Los factores que influyen en los resultados de depresión en la práctica clínica, sobre todo, la calidad de vida relacionada con la salud (CVRS), son relativamente desconocidos. El estudio de los Factores que Influyen en la Investigación de los Criterios de Valoración de la Depresión (FINDER) es un estudio europeo prospectivo de observación diseñado para estimar la CVRS de adultos con un episodio depresivo diagnosticado en la clínica inicialmente, y 3 y 6 meses después del comienzo del tratamiento antidepresivo. Describimos aquí el diseño del estudio y las características iniciales de los pacientes.

La CVRS se evaluó con el Cuestionario de Salud de 36 apartados (SF-36) y en el Cuestionario Europeo de Calidad de Vida de 5 Dimensiones (EQ-5D). También se determinaron las Puntuaciones de los pacientes en la Escala de Depresión, y Ansiedad Hospitalaria (HADS) y en la Escala Analógica Visual (EAV). Los resultados (n=3.468) demostraron que el resumen del componente mental del custionario SF-36 (media 22,2) estaba más de dos DE por debajo de la norma de la población general (media 50) y una DE por debajo de la norma de la depresión clínica (media 34,8); el resumen del componente físico (media 46,1) fue similar a la población general (media 50) y a la norma de depresión clínica (media 45). Las puntuaciones medias de EQ-5D eran tambien inferiores que la norma de la población general. Las puntuaciones medias de depresión y ansiedad de HADS eran 12,3 y 13, respectivamente. El 56% de los pacientes describió una puntuación total del dolor en la EAV de, al menos, 30 mm y el 70% de estos pacientes no tenía ninguna explicación física de su dolor.

Deben realizarse más investigaciones sobre los factores asociados con la CVRS en pacientes con depresión después de la iniciación del tratamiento.

Keywords

DepresiónEuropaEstudio de observaciónCalidad de vida
Type
Artículo original
Information
European Psychiatry (Ed. Española) , Volume 15 , Issue 4 , May 2008 , pp. 187 - 196
Copyright
Copyright © European Psychiatric Association 2008

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References

Bibliografia

[1]Anderson, IMHaddad, PM. The antidepressant debate should move on. Br J Psychiatry 2003; 182: 551-2.CrossRefGoogle Scholar
[2]Ayuso-Mateos, JLVazquez-Barquero, JLDowrick, CLehtinen, VDalgard, OSCasey, P, et al. Depressive disorders in Europe: prevalence figures from the OD1N study. Br J Psychiatry 2001; 179:308-16.CrossRefGoogle ScholarPubMed
[3]Bagby, RMRyder, AGCristi, C. Psychosocial and clinical predictors of response to pharmacotherapy for depression. Rev Psychiatr Neurosci 2002; 27: 250-7.Google ScholarPubMed
[4]Bair, MJRobinson, RLEckert, GJStang, PECroghan, TWKroenke, K. Impact of pain on depression treatment response in primary care. Psychosom Med 2004; 66: 17–22.CrossRefGoogle ScholarPubMed
[5]Bair, MJRobinson, RLKaton, WKroenke, K. Depression and pain comorbidity. Arch Tntern Med 2003; 163: 2433-45. A literature review.Google ScholarPubMed
[6]Barsky, AJWyshak, GKlerman, GL. Hypochondriasis. An evaluation of the DSM-I1I criteria in medical outpatients. Arch Gen Psychiatry 1986; 43: 493–500.Google ScholarPubMed
[7]Bauer, MMonz, BUMontejo, ALQuail, DDantchev, NDemyttenaere, K, et al. Prescribing patterns of antidepressants in Europe: results from the Factors Influencing Depression Endpoints Research (FINDER) study. Eur Psychiatry 2008; 23: 57–65.CrossRefGoogle ScholarPubMed
[8]Bijl, RVvan Zessen, GRavelli, Ade Rijk, CLangendoen, Y. The Netherlands Mental Health Survey and Incidence Study (NEMESIS): objectives and design. Soc Psychiatry Psychiatr Epidemiol 1998; 33: 581-6.CrossRefGoogle ScholarPubMed
[9]Bijur, PESilver, WGallagher, J. Reliability of the visual analogue scale for measurement of acute pain. Acad Emerg Med 2001; 8: 1153-7.CrossRefGoogle ScholarPubMed
[10]Bosworth, HBHays, JCGeorge, LKSteffens, DC. Psychosocial and clinical predictors of unipolar depression outcome in older adults. Int J Geriatr Psychiatry 2002; 17: 238-46.CrossRefGoogle ScholarPubMed
[11]Brooks, R, with the EuroQoL Group. EuroQol: the current State of play. Health Policy 1996; 37: 53–72.CrossRefGoogle ScholarPubMed
[12]Chakravarty, EFFries, JF. Science as experiment; Science as observation. Nat Clin Pract Rheumatol 2006; 2: 286-7.CrossRefGoogle ScholarPubMed
[13]Collins, SLMocre, AMcQuay, HJ. The visual analogue pain intensity scale: what is moderate pain in milumetres? Pain 1997; 72: 95-7.CrossRefGoogle Scholar
[14]Crawford, JRHenry, JDCrombie, CTaylor, EP. Normative data for the HADS from a large non-clinical sample. Br J Clin Psychol 2001; 40: 429-34.CrossRefGoogle ScholarPubMed
[15]Dolan, RModeling variations for EuroQol health States. Med Care 1997; 35: 1095-108.CrossRefGoogle Scholar
[16] ESEMeD/MHEDEA 2000 Investigators. Prevalence of mental disorders in Europe: results from the European Study of Epidemiology of Mental Disorders (ESEMeD) project. Acta Psychiatr Scand 2004; 109(Suppl. 420): 28–37.Google Scholar
[17]Eleck, MSimon, GHerrman, HBushnell, DMartin, MPatrick, D, On behalf of the LIDO Group. Major depression and its correlated in primary cure settings in six countries. Br J Psychiatry 2005; 186: 41-7.Google Scholar
[18]Garcia-Cebrian, AGandhi, PDemyttenaere, KPeveler, R. The association of depression and pain physical symptoms—a review of the European literature. Eur Psychiatry 2006; 21: 379-99.CrossRefGoogle ScholarPubMed
[19]Geddes, JButler, RHatcher, SCipriani, APrice, JCarney, S, et al. Depressive disorders. Clin Evid 2004; 12: 1391-436.Google Scholar
[20]Gibson, JLMartin, DKSinger, PA. Evidence, economics and ethics: resource aliocation in health Services organizations. Health Care Q 2005; 8: 50-9.Google ScholarPubMed
[21]Goldney, RDFisher, LJWilson, DHCheok, F. Major depression and its associated morbidity and quality of life in a random, representative community sample. Aust N Z J Psychiatry 2000; 34: 1022-9.CrossRefGoogle Scholar
[22]Greenberg, PEBirubaum, HG. The economic burden of depression in the US: societal and patient perspectives. Expert Opin Pharmacother 2005; 6: 369-76.CrossRefGoogle ScholarPubMed
[23]Haro, JMKontodimas, SNegrin, MARatcliffe, MSuarez, D, Windmeijer E Methodological aspects in the assessment and treatment effects in observational health outcome studies. Appl Health Econ Health Policy 2006; 5: 11–25.Google Scholar
[24]Hartz, AMarsh, JL. Methodologic issues in observational studies. Clin Orthop Relat Res 2003; 413: 33–42.CrossRefGoogle Scholar
[25]Hays, RDWells, KBSherbourne, CDRogers, WSpritzer, K. Functioning and well-being outcomes of patients with depression compared with chronic general medical illnesses. Arch Gen Psychiatry 1995; 52: 11-9.CrossRefGoogle ScholarPubMed
[26]Herrmann, C. International experiences with the Hospital Anxiety and Depression Scale—A review of validation data and clinical results. J Psychosom Res 1997; 42: 17–41.CrossRefGoogle ScholarPubMed
[27]Herrman, HPatrick, DLDiehr, PMartin, MLFleck, MSimon, GE, et al. Longitudinal investigation of depression outcomes in primary care in six countries: the LIDO study. Functional status, health Service use and treatment of people with depressive symptoms. Psychol Med 2002; 32: 889–902.Google ScholarPubMed
[28] International NetWork for Agencies for Health Technology Assessment (INAHTA). Avallable from: http://inahta.org/inahta_webRndex. asp [accessed 25.11.06].Google Scholar
[29]Keller, MB. Past, present and future directions for defining optimal treatment outcome in depression. Remission and beyond. J Am Med Assoc 2003; 289: 3152-60.CrossRefGoogle ScholarPubMed
[30]Kelly, AM. The minimum clinically significant difference in visual analogue scale pain score does not differ with severity of pain. EmergMedJ 2001; 18: 205-7.Google Scholar
[31]Kennedy, SH. A review of antidepressant treatments today. Eur Neuropsychopharmacol 2006; 16(Suppl. 5): S619-23.CrossRefGoogle Scholar
[32]Lepine, JPBriley, M. The epidemiology of pain in depression. Hum Psychopharmacol Clin Exp 2004; 19: S3-7.CrossRefGoogle ScholarPubMed
[33]Lepine, JPGastpart, MMendlowicz, JTylee, A, On behalf of the DEPRES steering committee. Depression in the community: the first pan-European study DEPRES (Depression Research in European Society). Int Clin Psychopharmacol 1997; 12: 19–29.CrossRefGoogle Scholar
[34]Murray, CJLopez, AD. Alternative projections of mortality and disability by cause 1990-2020: global burden of disease study. Lancet 1997; 349: 1498-504.CrossRefGoogle ScholarPubMed
[35]Mykletun, AStordal, EDahl, AA. Hospital anxiety and depression (HAD) scale: factor structure, Item analysis and internal consistency in a large population. Br J Psychiatry 2001; 179: 540-4.CrossRefGoogle ScholarPubMed
[36]Olsson, IMykletun, ADahl, AA. The hospital anxiety and depression rating scale: a cross-sectional study of psychometrics and case finding abilities in general practice. BMC Psychiatry 2005; 5: 46.CrossRefGoogle ScholarPubMed
[37]Paykel, ESBrugha, TFryers, T. Size and burden of depressive disorders in Europe. Eur Neuropsychopharmacol 2005; 15: 411-23.CrossRefGoogle ScholarPubMed
[38]Peveler, RGeorge, CKinmonth, ALCampbell, MThompson, C. Effect of antidepressant drug counselling and information leaflets on adherence to drug treatment in primary care: randomised controlled trial. BMJ 1999; 319: 612-5.CrossRefGoogle ScholarPubMed
[39]Simon, GE. Long-term prognosis of depression in primary care. Bull World Health Organ 2000; 78: 439-45.Google ScholarPubMed
[40]Szadoczky, ERozsa, SZambori, JFuredo, J. Predictors for 2-year outcome of major depressive episode. J Affect Disord 2004; 83: 49-57.CrossRefGoogle ScholarPubMed
[41]Szende, AWilliams, A, editors. Measuring self-reported population health: an international perspective based on EQ-SD. Hungary: Spring Medical Publishing; 2004.Google Scholar
[42]Tylee, AGastpar, MLepine, JPMendlewicz, J. DEPRES II (Depression Research in European Society II): a patient survey of the symptoms, disability and current management of depression in the community. Int Clin Psychopharmacol 1999; 14: 139-51.Google Scholar
[43]Tylee, AGhandi, P. The importance of somatic symptoms in depression in primary care. Prim Care Companion J Clin Psychiatry 2005; 7: 167-76.CrossRefGoogle ScholarPubMed
[44]Ware, JEGandek, BKosinski, MAaronson, NKApolone, GBrazier, J, et al. The equivalence of SF-36 summary health scores estimated using standard and country-specific algorithims in 10 countries: results from the IQOLA project. J Clin Epidemiol 1998; 51: 1167-70.CrossRefGoogle Scholar
[45]Ware, JEKosinski, MDewey, JE. How to score version 2 of the SF—36 health survey. Lincoln, RI: Quality Metric Incorporated; 2000.Google Scholar
[46]Wells, KBStewart, AHays, RDBurnam, MARogers, WDaniels, M, et al. The functioning and well-being of depressed patients. Results from the medical outcomes study. J Am Med Assoc 1989; 262: 914-9.Google ScholarPubMed
[47]Whalley, DMcKenna, SP. Measuring quality of life in patients with depression or anxiety. Pharmacoeconomics 1995; 8: 305-15.CrossRefGoogle ScholarPubMed
[48]Zigmond, ASSnaith, RP. The Hospital Anxiety and Depression Scale. Acta Psychiatr Scand 1983; 67: 361-70.CrossRefGoogle ScholarPubMed