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Tratamiento combinado de clozapina y litio para la esquizofrenia y el trastorno esquizoafectivo

Published online by Cambridge University Press:  12 May 2020

M. Moldavsky ,
D. Stein ,
R. Benatov ,
P. Sirota ,
A. Elizur ,
Y. Matzner  and
A. Weizman
M. Moldavsky
Affiliation:
Centro de Salud Mental Abarbanel, 15 Keren Kayemet St, Bat- Yam, Israel, afiliado a la Facultad Sackler de Medicina, TelAviv University, TelAviv, lsrael
D. Stein
Affiliation:
Centro de Salud Mental Abarbanel, 15 Keren Kayemet St, Bat- Yam, Israel, afiliado a la Facultad Sackler de Medicina, TelAviv University, TelAviv, lsrael
R. Benatov
Affiliation:
Centro de Salud Mental Abarbanel, 15 Keren Kayemet St, Bat- Yam, Israel, afiliado a la Facultad Sackler de Medicina, TelAviv University, TelAviv, lsrael
P. Sirota
Affiliation:
Centro de Salud Mental Abarbanel, 15 Keren Kayemet St, Bat- Yam, Israel, afiliado a la Facultad Sackler de Medicina, TelAviv University, TelAviv, lsrael
A. Elizur
Affiliation:
Centro de Salud Mental Abarbanel, 15 Keren Kayemet St, Bat- Yam, Israel, afiliado a la Facultad Sackler de Medicina, TelAviv University, TelAviv, lsrael
Y. Matzner
Affiliation:
Unidad de Hematología, Hospital Universitario Hadassah, Mount Scopus, Jerusalem, Israel
A. Weizman
Affiliation:
Hospital Psiquiátrico Geha y Centro Médico Felsenstein, Beilinson Medical Campus, Peath Tiqva, Israel afiliado a la Facultad Sackler de Medicina, TeI Aviv University, Tel Aviv, Israel
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Resumen

Tres adolescentes y dos pacientes adultos que sufrían psicosis crónicas con excitación (esquizofrenia o trastorno esquizoafectivo) resistentes a los neurolépticos tradicionales y a la clozapina recibieron tratamiento con una combinación de clozapina y litio. La mejoría se evaluó con la Escala de Síntomas Positivos y Negativos, la Escala de Evaluación Psiquiátrica Breve y las Impresiones Clínicas Globales, administradas antes y durante el tratamiento combinado de clozapina y litio. Todos los pacientes demostraron una mejoría significativa con esta combinación. No se produjo agranulocitosis, síndrome neuroléptico maligno u otros efectos adversos significativos clínicamente.

Keywords

clozapinalitioesquizofreniatrastorno esquizoafectivo
Type
Comunicación Breve
Information
European Psychiatry (Ed. Española) , Volume 7 , Issue 5 , June 2000 , pp. 310 - 313
Copyright
Copyright © European Psychiatric Association 2000

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