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Apolipoprotein-E gene variants associated with cardiovascular risk factors in antipsychotic recipients

Published online by Cambridge University Press:  16 April 2020

D. Clark ,
O.A. Skrobot ,
I. Adebiyi ,
M.T. Susce ,
J. de Leon ,
AI.F. Blakemore  and
M.J. Arranz
D. Clark
Affiliation:
Department of Psychological Medicine, Institute of Psychiatry, King's College, 1, Windsor Walk, PO51, LondonSE5 8AF, UK
O.A. Skrobot
Affiliation:
Department of Psychological Medicine, Institute of Psychiatry, King's College, 1, Windsor Walk, PO51, LondonSE5 8AF, UK
I. Adebiyi
Affiliation:
Section of Genomic Medicine, Imperial College London, Hammersmith Hospital Campus, Du Cane Road, East Acton, LondonW12 0NN, UK
M.T. Susce
Affiliation:
University of Kentucky, Mental Health Research Center at Eastern State Hospital, Lexington, KY, USA
J. de Leon
Affiliation:
University of Kentucky, Mental Health Research Center at Eastern State Hospital, Lexington, KY, USA
AI.F. Blakemore
Affiliation:
Section of Genomic Medicine, Imperial College London, Hammersmith Hospital Campus, Du Cane Road, East Acton, LondonW12 0NN, UK
M.J. Arranz*
Affiliation:
Department of Psychological Medicine, Institute of Psychiatry, King's College, 1, Windsor Walk, PO51, LondonSE5 8AF, UK
*
*Corresponding author. E-mail address:m.arranz@kcl.ac.uk (M.J. Arranz).
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Abstract

Interest exists in identifying the factors that specifically contribute to the increased prevalence of cardiovascular disease observed in psychiatric disease. The apolipoprotein-E (APOE) gene codes for a protein that has a key role in metabolism of cholesterol and triglycerides, with increased levels of apoE found in specific areas of post-mortem schizophrenic brains. This study investigated whether apoE variants influence the prevalence of cardiovascular risk factors (obesity, diabetes and dyslipidaemia), in patients receiving antipsychotic treatment, due to extension of the risk seen in the general population, but also due to the role of the APOE gene in mediating antipsychotic-induced side effects. Seven polymorphisms (rs741780, rs483082, rs429358, rs7412, rs10119, rs439401 and rs405509) were genotyped in 427 American Caucasian patients who were either receiving, or had been prescribed risperidone. Our results support the hypothesis that APOE gene variants influence the prevalence of diabetes and possibly overweight in psychiatric patients. Unfortunately, due to the cross sectional nature of this study, the contribution of antipsychotic treatment was not determined. These associations warrant prospective study to assess interaction between APOE gene variants and the propensity of antipsychotics to induce cardiovascular risk factors.

Keywords

APOECardiovascular diseaseObesityAntipsychoticsSchizophrenia
Type
Original article
Information
European Psychiatry , Volume 24 , Issue 7 , October 2009 , pp. 456 - 463
Copyright
Copyright © Elsevier Masson SAS 2008

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