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Early development and unstable genes in schizophrenia: preliminary results

Published online by Cambridge University Press:  16 April 2020

Agnes Ayton ,
Alex G. Morris ,
Philip J. Tyson ,
David Hunt ,
Ann M. Mortimer  and
David Cottrell
Agnes Ayton*
Affiliation:
Department of Psychiatry, University of Hull, East Riding Campus, Coniston House, Willerby, East YorkshireHU10 6NS, UK
Alex G. Morris
Affiliation:
Institute of Ophthalmology, UCL 43 Bath Street, London, EC1V 9EL, UK
Philip J. Tyson
Affiliation:
Department of Psychiatry, University of Hull, East Riding Campus, Coniston House, Willerby, East YorkshireHU10 6NS, UK
David Hunt
Affiliation:
Institute of Ophthalmology, UCL 43 Bath Street, London, EC1V 9EL, UK
Ann M. Mortimer
Affiliation:
Department of Psychiatry, University of Hull, East Riding Campus, Coniston House, Willerby, East YorkshireHU10 6NS, UK
David Cottrell
Affiliation:
Academic Unit of Child and Adolescent Mental Health, 12Clarendon Rd, LeedsLS2 9NN, UK
*
*E-mail address:A.K.Ayton@hull.ac.uk (A. Ayton).
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Summary

Background.

Trinucleotide repeats have been associated with schizophrenia, but the evidence, based on cross-sectional clinical information, is equivocal.

Aims.

To examine the relationship between genomic CAG/CTG repeat size and premorbid development in schizophrenia.

Method.

Early development and premorbid functioning of 22 patients with DSM-IV diagnosis of schizophrenia were assessed by parental interviews. Repeat expansion detection (RED) technique was used to measure genomic CAG/CTG repeat size, and PCR for CAG repeat size at the ERDA-1 and CTG 18.1 loci.

Results.

There was an inverse association between CAG/CTG size and perinatal complications. Patients with speech and motor developmental delay had larger repeats. The results were not due to expansion in the ERDA-1 and CTG 18.1 genes.

Conclusions.

CAG/CTG repeat expansion is associated with speech and motor developmental delay in schizophrenia. We propose that the developmental model may be useful for research into the genetics of schizophrenia.

Keywords

SchizophreniaEarly development–geneticsTrinucleotide repeats
Type
Original article
Information
European Psychiatry , Volume 17 , Issue 6 , October 2002 , pp. 332 - 338
Copyright
Copyright © Éditions scientifiques et médicales Elsevier SAS 2002

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