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Early predictors of two month response with mianserin and selective serotonin reuptake inhibitors and influence of definition of outcome on prediction

Published online by Cambridge University Press:  16 April 2020

I Berlin  and
F Lavergne
I Berlin
Affiliation:
Department of Pharmacology, Hôpital Pitié-Salpêtrière, 47 Bd de l'Hôpital, 75013Paris
F Lavergne
Affiliation:
Department of Psychiatry, Organon France, Saint-Denis, France
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Summary

In order to identify clinical and demographic variables that predict response to antidepressants and to analyse prediction of outcome as a function of definition of outcome we analysed pooled data of two independent, multicentre, double blind parallel group studies. Study I compared the efficacy of mianserin with that of fluoxetine in 65, and study II compared mianserin with fluvoxamine in 60 patients with depression. Improvement was defined as at least 20% decrease in MADRS by day 14. Patients were considered as responders if they had greater than 50% decrease and non-responders if they had ≤ 50% decrease from baseline in the MADRS at day 56. Complete remission was defined as MADRS score ≤ 6 at day 56. Patients' characteristics did not differ between mianserin and SSRI groups. Early improvement predicted response in 92% and complete remission in 55% of the patients improved at day 14. Multivariate forward stepwise logistic regression analysis showed that response to treatments at day 56 was significantly (P = 0.0003) associated with early improvement, age (responders had higher age than non-responders) and weight (responders weighted more than non-responders). Complete remission was only predicted by early improvement. Treatments could not be differentiated when data were analysed according to responder/nonresponder status or complete remission/no complete remission. However, when the same data were analysed by analysis of variance a significant treatment effect (P = 0.02, mianserin > SSRIs) and a quadratic type treatment by time interaction (P = 0.023) were found. The robustness of the analysis was further improved by inclusion of covariates (age, weight). Early clinical improvement seems to be the best predictor of 2 month response to antidepressants (mianserin, SSRIs). Younger age and lower weight may predict non-response. Quantitative analysis differentiates treatments better than analysis of responder status. As obtenation of complete remission is a realistic objective with current antidepressants, studies longer than 2 months are needed to assess effectiveness of these drugs in the obtenation of complete remission.

Keywords

antidepressanttreatment responsepredictors
Type
Research Article
Information
European Psychiatry , Volume 13 , Issue 3 , May 1998 , pp. 138 - 142
Copyright
Copyright © Elsevier, Paris 1998

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References

American Psychiatric Association Diagnostic and statistical manual of mental disorders Third edition. APA Stuttgart 1980Google Scholar
Hamilton, MThe assessment of anxiety by rating Br J Med Psychol 1959; 32: 50–55CrossRefGoogle ScholarPubMed
Ko, HC, Lu, RB, Shiah, IS, Hwang, CCPlasma free 3-methoxy-4-hydorxyphenylglycol predicts response to fluoxetine Biol Psychiatry 1997; 41: 774–781CrossRefGoogle ScholarPubMed
Maier, W, Philipp, M, Buller, R, Schlegel, SReliability and validity of the Newcastle Scale in relation to ICD-9 classification Acta Psychiatr Scand 1987; 76: 619–627CrossRefGoogle ScholarPubMed
Montgomery, SA, Asberg, MA new depression scale designed to be sensitive to change Br J Psychiatry 1979; 134: 382–389CrossRefGoogle ScholarPubMed
Nierenberg, AATreatment choice after one antidepressant fails: a survey of North-eastern psychiatrists J Clin Psychiatry 1991; 52: 383–385Google Scholar
Nierenberg, AA, McLean, NE, Alpert, JE, Worthington, JJ, Rosenbaum, JF, Fava, MEarly nonresponse to fluoxetine as a predictor of poor 8-week outcome Am J Psychiatry 1995; 152: 1500–1503Google ScholarPubMed
Radat, F, Berlin, I, Spreux-Varoquaux, O, Elatki, S, Ferreri, M, Puech, AJInitial monoamine oxidase-A inhibition by moclobemide does not predict the therapeutic response in patients with major depression Psychopharmacology 1996; 127: 370–376CrossRefGoogle Scholar
Snaith, RP, Harrop, FM, Newby, DA, Teale, CGrade scores of the Montgomery-Asberg Depression and the Clinical Anxiety Scales Br J Psychiatry 1986; 148: 599–601CrossRefGoogle ScholarPubMed
Stassen, HH, Angst, J, Delini-Stula, ADelayed onset of action of antidepressant drugs? Survey of results of Zurich meta-analyses Pharmacopsychiatr 1996; 29: 87–96CrossRefGoogle Scholar
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