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Effects of atypical and typical antipsychotic treatments on sexual function in patients with schizophrenia: 12-month results from the Intercontinental Schizophrenia Outpatient Health Outcomes (IC-SOHO) study

Published online by Cambridge University Press:  16 April 2020

Martin Dossenbach ,
Yulia Dyachkova ,
Sebnem Pirildar ,
Martin Anders ,
Afaf Khalil ,
Aleksander Araszkiewicz ,
Tamara Shakhnovich ,
Aly Akram ,
Jan Pecenak  and
Margaret McBride
...Show all authors
Martin Dossenbach*
Affiliation:
Eli Lilly and Company, Ges.m.b.H, Köclblgasse 8-10, 1030Vienna, Austria
Yulia Dyachkova
Affiliation:
Eli Lilly and Company, Ges.m.b.H, Köclblgasse 8-10, 1030Vienna, Austria
Sebnem Pirildar
Affiliation:
Ege University, Medical Faculty, Department of Psychiatry, Izmir, Turkey
Martin Anders
Affiliation:
Department of Psychiatry 1st Medical Faculty, Charles University, Ke Karlovu 11, 120 00Prague 2, Czech Republic
Afaf Khalil
Affiliation:
Ein Shames University Hospital, Department of Psychiatry, Heliopolis, Cairo, Egypt
Aleksander Araszkiewicz
Affiliation:
Department of Psychiatry, Bydgoszcz University Medical School, Poland
Tamara Shakhnovich
Affiliation:
Psychiatry Hospital N4, 3 Poteshnaya Str., 123298, Moscow, Russia
Aly Akram
Affiliation:
Suliman Faqueeh Hospital, Jeddah, Saudi Arabia
Jan Pecenak
Affiliation:
Department of Psychiatry, Faculty of Medicine, Comenius University, University Hospital Bratislava, Mickiewiczova 13, 81369Bratislava, Slovakia
Margaret McBride
Affiliation:
Eli Lilly and Company, Sydney, Australia
Tamas Treuer
Affiliation:
Eli Lilly and Company, Ges.m.b.H, Köclblgasse 8-10, 1030Vienna, Austria
*
*Corresponding author. Tel.: +43 1711 78 624; fax: +43 1711 78551. E-mail address: d.m@lilly.com (M. Dossenbach).
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Abstract

Purpose

Sexual dysfunction in patients with schizophrenia can reduce quality of life and treatment compliance. This report will compare the effects of selected atypical and typical antipsychotics on sexual function in a large, international population of outpatients with schizophrenia who were treated over 1 year.

Subjects and methods

Outpatients with schizophrenia, who initiated or changed antipsychotic treatment, and entered this 3-year, prospective, observational study were classified according to the monotherapy prescribed at baseline: olanzapine (N = 2638), risperidone (N = 860), quetiapine (N = 142) or haloperidol (N = 188).

Results

Based on patient perception, the odds of experiencing sexual dysfunction during 1 year of therapy was significantly lower for patients treated with olanzapine and quetiapine when compared to patients who received risperidone or haloperidol (all P ≤ 0.001). Females on olanzapine (14%) or quetiapine (8%) experienced a lower rate of menstrual irregularities, compared to females on risperidone (23%) or haloperidol (29%). Significant discordance was evident between patient reports and psychiatrist perception of sexual dysfunction, with psychiatrists underestimating sexual dysfunction (P ≤ 0.001).

Conclusions

These findings indicate clinically relevant differences exist in the sexual side effect profiles of these selected antipsychotics. These factors should be considered when selecting the most appropriate treatment for outpatients with schizophrenia.

Keywords

SchizophreniaSexual dysfunctionHyperprolactinemiaAntipsychotic agents
Type
Original articles
Information
European Psychiatry , Volume 21 , Issue 4 , June 2006 , pp. 251 - 258
Copyright
Copyright © European Psychiatric Association 2006

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