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The hippocampus and depression

Published online by Cambridge University Press:  16 April 2020

Y.I. Sheline ,
B.L. Mittler  and
M.A. Mintun
Y.I. Sheline*
Affiliation:
Department of Psychiatry, Washington University School of Medicine, St. Louis, MO63110, USA Department of Radiology, Washington University School of Medicine, St. Louis, MO63110, USA Department of Neurology, Washington University School of Medicine, St. Louis, MO63110, USA Mallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, MO63110, USA
B.L. Mittler
Affiliation:
Department of Psychiatry, Washington University School of Medicine, St. Louis, MO63110, USA
M.A. Mintun
Affiliation:
Department of Psychiatry, Washington University School of Medicine, St. Louis, MO63110, USA Department of Radiology, Washington University School of Medicine, St. Louis, MO63110, USA Mallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, MO63110, USA
*
*Corresponding author: WUSM, Box 8134, 660 S. Euclid Ave, St. Louis, MO 63110, USA.
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Summary

The effect of depression on the hippocampus has become the focus of a number of structural and functional neuroimaging studies. In the past two decades, advances in neuroimaging techniques now allow the examination of subtle changes in both regional structure and function that are associated with the pathophysiology of depression. Many studies using 3-dimensional magnetic resonance imaging (MRI) volumetric measurement have reported decreases in hippocampal volume among depressed subjects compared with controls, whereas other studies have not found any volume loss. Differences among studies have been discussed. In some studies, the volume loss appears to have functional significance including an association with memory loss. Furthermore, we have found a trend towards loss of 5-HT2A receptors in the hippocampus using positron emission tomography (PET) to detect regional changes in [18F]altanserin binding. Functional imaging extends the sensitivity and specificity of structural imaging and will lead to a better understanding of affective disorders.

Keywords

DepressionHippocampusNeuroimagingSerotoninVolumetric change
Type
Research Article
Information
European Psychiatry , Volume 17 , Issue S3: A new pharmacology of depression: the concept of synaptic plasticity , July 2002 , pp. 300s - 305s
Copyright
Copyright Éditions scientifiques et médicales Elsevier SAS 2002

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Footnotes

To be presented at ECNP Barcelona, 5-9 October 2002, during the symposium “A new pharmacology of depression: the concept of synaptic plasticity.”

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