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Oral Disease in Relation to Future Risk of Dementia and Cognitive Decline: Prospective Cohort Study Based on the Action in Diabetes and Vascular Disease: Preterax and Diamicron Modified-Release Controlled Evaluation (Advance) Trial

Published online by Cambridge University Press:  02 October 2011

G.-D. Batty ,
Q. Li ,
R. Huxley ,
S. Zoungas ,
B.-A. Taylor ,
B. Neal ,
B. de Galan ,
M. Woodward ,
S.-B. Harrap  and
S. Colagiuri
...Show all authors
G.-D. Batty*
Affiliation:
Department of Epidemiology and Public Health, University College of London, Torrington Place, London, UK The George Institute for International Health, University of Sydney, Sydney, Australia Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, UK Medical Research Council Social and Public Health Sciences Unit, Glasgow, UK
Q. Li
Affiliation:
The George Institute for International Health, University of Sydney, Sydney, Australia
R. Huxley
Affiliation:
The George Institute for International Health, University of Sydney, Sydney, Australia
S. Zoungas
Affiliation:
The George Institute for International Health, University of Sydney, Sydney, Australia School of Public Health, Monash University, Melbourne, Australia
B.-A. Taylor
Affiliation:
Department of Oral Biology, University of Oslo, Oslo, Norway
B. Neal
Affiliation:
The George Institute for International Health, University of Sydney, Sydney, Australia
B. de Galan
Affiliation:
The George Institute for International Health, University of Sydney, Sydney, Australia Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
M. Woodward
Affiliation:
The George Institute for International Health, University of Sydney, Sydney, Australia Mount Sinai School of Medicine, New York, United States
S.-B. Harrap
Affiliation:
Department of Physiology, University of Melbourne, Melbourne, Australia
S. Colagiuri
Affiliation:
Institute of Obesity, Nutrition and Exercise, University of Sydney, Sydney, Australia
A. Patel
Affiliation:
The George Institute for International Health, University of Sydney, Sydney, Australia
J. Chalmers
Affiliation:
The George Institute for International Health, University of Sydney, Sydney, Australia
*
⁎Corresponding author. E-mail address: david.batty@ucl.ac.uk (G.-D. Batty).
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Abstract

Objective

Examine the association of oral disease with future dementia/cognitive decline in a cohort of people with type 2 diabetes.

Methods

A total of 11,140 men and women aged 55–88 years at study induction with type 2 diabetes participated in a baseline medical examination when they reported the number of natural teeth and days of bleeding gums. Dementia and cognitive decline were ascertained periodically during a 5-year follow-up.

Results

Relative to the group with the greatest number of teeth (more than or equal to 22), having no teeth was associated with the highest risk of both dementia (hazard ratio; 95% confidence interval: 1.48; 1.24, 1.78) and cognitive decline (1.39; 1.21, 1.59). Number of days of bleeding gums was unrelated to these outcomes.

Conclusions

Tooth loss was associated with an increased risk of both dementia and cognitive decline.

Keywords

Cognitive declineCohort studyDementiaOral disease
Type
Short communication
Information
European Psychiatry , Volume 28 , Issue 1 , January 2013 , pp. 49 - 52
Copyright
Copyright © European Psychiatric Association 2013

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