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The relationship of impulsivity to response inhibition and decision-making in remitted patients with bipolar disorder

Published online by Cambridge University Press:  16 April 2020

T. Christodoulou ,
M. Lewis ,
G.B. Ploubidis  and
S. Frangou
T. Christodoulou
Affiliation:
Section of Neurobiology of Psychosis (PO66), Institute of Psychiatry, De Crespigny Park, LondonSE5 8AF, UK
M. Lewis
Affiliation:
Section of Neurobiology of Psychosis (PO66), Institute of Psychiatry, De Crespigny Park, LondonSE5 8AF, UK
G.B. Ploubidis
Affiliation:
Department of Psychiatry, University of Cambridge, UK
S. Frangou*
Affiliation:
Section of Neurobiology of Psychosis (PO66), Institute of Psychiatry, De Crespigny Park, LondonSE5 8AF, UK
*
*Corresponding author. E-mail address: s.frangou@iop.kcl.ac.uk (S. Frangou).
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Abstract

Background

Impulsivity, a core feature of bipolar disorder (BD), is a multifaceted concept encompassing failure of response inhibition and poor decision-making. Abnormalities in these two cognitive domains have been reported in BD patients but their relationship with impulsivity has not been explored.

Methods

Twenty-five remitted patients with BD completed the Barratt Impulsiveness Scale (BIS) and performed the Hayling Sentence Completion Task (HSCT) and a computerized version of the Iowa Gambling task. The HSCT total errors scaled score was used as a measure of response inhibition while the gabling task score, which reflects participants' ability to make advantageous choices, was used a measure of decision making.

Results

Higher scores on the BIS attentional and non-planning subscales were respectively associated with more errors in the HSCT and less advantageous choices in the gambling task.

Limitations

All patients were medicated. Healthy participants were not included.

Conclusions

Viewed in the context of recent relevant studies our findings suggest that impulsivity, response inhibition and decision-making in BD may represent behavioural manifestations of the same underlying biological mechanism possibly linked to ventral prefrontal cortical function.

Keywords

Bipolar disorderImpulsivityResponse inhibitionDecision making
Type
Original articles
Information
European Psychiatry , Volume 21 , Issue 4 , June 2006 , pp. 270 - 273
Copyright
Copyright © European Psychiatric Association 2006

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