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Shared genetic factors influence risk for bipolar disorder and alcohol use disorders

Published online by Cambridge University Press:  15 April 2020

N. Carmiol ,
J.M. Peralta ,
L. Almasy ,
J. Contreras ,
A. Pacheco ,
M.A. Escamilla ,
E.E.M. Knowles ,
H. Raventós  and
D.C. Glahn
N. Carmiol
Affiliation:
Centro de Investigación en Biología Molecular y Celular, Universidad de Costa Rica, San José, Costa Rica
J.M. Peralta
Affiliation:
Centro de Investigación en Biología Molecular y Celular, Universidad de Costa Rica, San José, Costa Rica Department of Genetics, Texas Biomedical Research Institute, San Antonio, TX, USA
L. Almasy
Affiliation:
Department of Genetics, Texas Biomedical Research Institute, San Antonio, TX, USA
J. Contreras
Affiliation:
Centro de Investigación en Biología Molecular y Celular, Universidad de Costa Rica, San José, Costa Rica
A. Pacheco
Affiliation:
Centro de Investigación en Biología Molecular y Celular, Universidad de Costa Rica, San José, Costa Rica
M.A. Escamilla
Affiliation:
Center of Excellence for Neurosciences, Texas Tech University Health Science Center, El Paso, TX, USA
E.E.M. Knowles
Affiliation:
Olin Neuropsychiatry Research Center, Institute of Living, Hartford, CT, USA Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA
H. Raventós
Affiliation:
Centro de Investigación en Biología Molecular y Celular, Universidad de Costa Rica, San José, Costa Rica Escuela de Biología, Universidad de Costa Rica, San José, Costa Rica
D.C. Glahn*
Affiliation:
Olin Neuropsychiatry Research Center, Institute of Living, Hartford, CT, USA Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA
*
*Corresponding author. Olin Neuropsychiatry Research Center, Whitehall Research Building, Institute of Living, 200 Retreat Ave, Hartford, CT 06106, USA. Tel.: +1 860 5457298; fax: +1 860 545 7797. E-mail address:david.glahn@yale.edu (D.C. Glahn).
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Abstract

Bipolar disorder and alcohol use disorder (AUD) have a high rate of comorbidity, more than 50% of individuals with bipolar disorder also receive a diagnosis of AUD in their lifetimes. Although both disorders are heritable, it is unclear if the same genetic factors mediate risk for bipolar disorder and AUD. We examined 733 Costa Rican individuals from 61 bipolar pedigrees. Based on a best estimate process, 32% of the sample met criteria for bipolar disorder, 17% had a lifetime AUD diagnosis, 32% met criteria for lifetime nicotine dependence, and 21% had an anxiety disorder. AUD, nicotine dependence and anxiety disorders were relatively more common among individuals with bipolar disorder than in their non-bipolar relatives. All illnesses were shown to be heritable and bipolar disorder was genetically correlated with AUD, nicotine dependence and anxiety disorders. The genetic correlation between bipolar and AUD remained when controlling for anxiety, suggesting that unique genetic factors influence the risk for comorbid bipolar and AUD independent of anxiety. Our findings provide evidence for shared genetic effects on bipolar disorder and AUD risk. Demonstrating that common genetic factors influence these independent diagnostic constructs could help to refine our diagnostic nosology.

Keywords

Bipolar disorderAlcohol use disorderFamily studiesHeritabilityGenetic correlationCentral Valley of Costa Rica
Type
Original articles
Information
European Psychiatry , Volume 29 , Issue 5 , June 2014 , pp. 282 - 287
Copyright
Copyright © Elsevier Masson SAS 2014

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