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Sulpiride adjunction to clozapine in treatment-resistant schizophrenic patients: a preliminary case series study

Published online by Cambridge University Press:  16 April 2020

R Shiloh ,
Z Zemishlany ,
D Aizenberg  and
A Weizman
R Shiloh
Affiliation:
Geha Psychiatric Hospital, Petah Tikva, and Sackler Faculty of Medicine, Felsenstein Medical Research Center, Tel Aviv University, Tel Aviv, Israel
Z Zemishlany
Affiliation:
Geha Psychiatric Hospital, Petah Tikva, and Sackler Faculty of Medicine, Felsenstein Medical Research Center, Tel Aviv University, Tel Aviv, Israel
D Aizenberg
Affiliation:
Geha Psychiatric Hospital, Petah Tikva, and Sackler Faculty of Medicine, Felsenstein Medical Research Center, Tel Aviv University, Tel Aviv, Israel
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Summary

Six chronic neuroleptic-resistant schizophrenic patients, partial responders to clozapine, were co-administered 600 mg/day of sulpiride (a selective D2 dopaminergic antagonist) as an augmentation to clozapine (a relatively weak D2 blocker), for 10 weeks, open-labeled. A remarkable reduction in positive and negative symptoms was observed in four of the six patients.

Keywords

schizophreniaclozapinesulpiridedopamineprolactin
Type
Case report
Information
European Psychiatry , Volume 12 , Issue 3 , 1997 , pp. 152 - 155
Copyright
Copyright © Elsevier, Paris 1997

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