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Time-dependent effect analysis of antipsychotic treatment in a naturalistic cohort study of patients with schizophrenia

Published online by Cambridge University Press:  15 April 2020

R.A. Kroken ,
L.S. Mellesdal ,
T. Wentzel-Larsen ,
H.A. Jørgensen  and
E. Johnsen
R.A. Kroken*
Affiliation:
Division of Psychiatry, Haukeland University Hospital, Pb 23, 5812Bergen, Norway
L.S. Mellesdal
Affiliation:
Division of Psychiatry, Haukeland University Hospital, Pb 23, 5812Bergen, Norway
T. Wentzel-Larsen
Affiliation:
Centre for Clinical Research, Haukeland University Hospital, Pb 23, 5812Bergen, Norway Norwegian Centre for Violence and Traumatic Stress Studies, Kirkeveien 166, building 48, 0407Oslo, Norway Centre for Child and Adolescent Mental Health, Eastern and Southern Norway, Kirkeveien 166, building 48, 0407Oslo, Norway
H.A. Jørgensen
Affiliation:
Division of Psychiatry, Haukeland University Hospital, Pb 23, 5812Bergen, Norway
E. Johnsen
Affiliation:
Division of Psychiatry, Haukeland University Hospital, Pb 23, 5812Bergen, Norway
*
*Corresponding author. Tel.: +47 55 95 84 00; fax: +47 55 95 84 36. E-mail address:rune.kroken@helse-bergen.no
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Abstract

Objective

Evidence based treatment of schizophrenia as well as antipsychotic drug utility patterns have changed considerably in recent years and the present study aims to investigate the current level of unplanned hospital readmissions in a cohort of patients with schizophrenia, and to determine the risk-reducing effects of current antipsychotic drug treatment.

Method

An open cohort study included all consecutively discharged patients with schizophrenia in a 3-year period (n = 277). The treatment-dependent variables were entered in a multivariate Cox survival analyses with time to unplanned readmission as the dependent variable.

Results

11.2% of patients were readmitted within 30days of discharge, and 44.8% were readmitted within 12months. Antipsychotic monotherapy reduced the risk of readmission by 74.9%. Treatment in CMHC also had a risk-reducing effect. The prescription rate of clozapine in this sample was 10.1%.

Discussion

The over-all level of unplanned readmissions was in correspondence with the findings of others. Current antipsychotic drug treatment independently offers strong protection against unplanned readmissions. There may be a potential for further optimalizing antipsychotic drug treatment according to treatment guidelines.

Conclusions

Unplanned readmissions are very common for patients with schizophrenia but antipsychotic drug treatment is associated with a strong risk-reducing effect in this regard.

Keywords

Schizophrenia and psychosisAntipsychoticsPsychiatry in Europe
Type
Original articles
Information
European Psychiatry , Volume 27 , Issue 7 , October 2012 , pp. 489 - 495
Copyright
Copyright © European Psychiatric Association 2012

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