Hostname: page-component-cd9895bd7-hc48f Total loading time: 0 Render date: 2024-12-25T13:47:17.657Z Has data issue: false hasContentIssue false
  • English
  • Français

Verapamil treatment in clozapine-induced sleep-related enuresis: a case report

Published online by Cambridge University Press:  16 April 2020

M Pojurovsky ,
M Schneidman ,
M Mark  and
A Weizman
M Pojurovsky
Affiliation:
Sha’ar Menashe Psychiatric Hospital, Hadera Tirat Camel Psychiatric Hospital, Haifa
M Schneidman
Affiliation:
Tirat Camel Psychiatric Hospital, Haifa
M Mark
Affiliation:
Mental Health Services, Israel Ministry of Health
A Weizman*
Affiliation:
Research Unit, Geha Psychiatric Hospital, and Felsenstein Medical Research Center, Beilinson Medical Center, PO Box 102, Sackler Faculty of Medicine, Tel Aviv University, Petah Tiqva49100, Israel
*
*Correspondence and reprints.
Get access

Summary

Enuresis is an embarrassing rare side effect of clozapine treatment. Using single-blind placebo-control design, the antienuretic activity of the calcium channel blocker verapamil (up to 80 mg/day per os, at 21.00 hours) was evaluated in a schizophrenic patient with comorbid obsessive-compulsive disorder (OCD) who developed nocturnal functional enuresis during clozapine treatment. Verapamil (80 mg/day) displayed antienuretic activity. No correlation between the bradycardiac effect and the antienuretic activity of verapamil was detected.

Keywords

enuresisclozapineverapamil
Type
Case report
Information
European Psychiatry , Volume 10 , Issue 8 , 1995 , pp. 413 - 415
Copyright
Copyright © Elsevier, Paris 1995

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Cohen, MAAlfonso, CAMosquera, MDevelopment of urinary retention during treatment with clozapine and meclizine. Am J Psych 1994; 151: 619–20Google ScholarPubMed
Ferrie, BGMactarlane, JGlen, ESDDAVP in young enuretic patients: a double blind trial. Br J Urol 1984; 56: 376–8CrossRefGoogle ScholarPubMed
Goton, MHassouna, MElhilali, MIntravesical instillation of verapamil and its effect on detrusor contractility. In vitro and in vivo studies. J Urology 1986; 135: 218AGoogle Scholar
Grinshpoon, AMark, MApter, AModai, IBleich, ARehavi, MWeizman, AFailure of fixed-dose verapamil treatment in adult sleep-related enuresis. Eur Psychiatry 1994; 9: 101–3CrossRefGoogle Scholar
Kuchenhoff, BDie wichtigsten Nebenwirkungen unter clozapine (Leponex) und ihre Behandlung. Psychiatr Praxis 1993; 20: 201–6Google Scholar
Liberman, JAKane, JMJohns, CAClozapine: guidelines for clinical management. J Clin Psychiatry 1989; 50: 329–38Google Scholar
Merschel, AOberle, JRangoni, FLa clozapine effects indesirables: étude dans les CHS de la région Alsace. La Pharmac Hosp Franc 1993; 106: 231–42Google Scholar
Mozes, TToren, PChernuzan, N, et al. Clozapine treatment in very early onset schizophrenia. J Am Acad Child Adolesc Psychiatry 1994; 33: 65–70CrossRefGoogle ScholarPubMed
Palmer, TWorth, PExton-Smith, AFlunarizine: a once-daily therapy for urinary incontinence. Lancet 1981; 8: 279–81CrossRefGoogle Scholar
Safferman, AUpdate on the clinical efficacy and side effects of clozapine. Schizophren Bull 1991; 17: 247–61CrossRefGoogle ScholarPubMed
Rud, TAnderson, REUlmster, UEffects of nifedipine in women with unstable bladder. Urol Int 1979; 34: 421–9CrossRefGoogle Scholar
Safferman, AUpdate on the clinical efficacy and side effects of clozapine. Schizophren Bull 1991; 17: 247–61CrossRefGoogle ScholarPubMed
Warner, JPHarvey, CABarnes, TREClozapine and urinary incontinence. Int Clin Psychopharmacol 1994; 9: 207–9CrossRefGoogle ScholarPubMed
Submit a response

Comments

No Comments have been published for this article.