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Are platelet serotonin levels and platelet mao activity the biological markers for the progress of alzheimer’s disease?

Published online by Cambridge University Press:  16 April 2020

P. Presečki ,
D. Muck Šeler ,
N. Mimica ,
M. Mustapić ,
N. Pivac ,
M. Mihanović ,
G. Nedić  and
V. Folnegović-Šmalc
P. Presečki
Affiliation:
Dartment of Psychiatry, Psychiatric Hospital Sveti Ivan, Zagreb, Croatia
D. Muck Šeler
Affiliation:
Division of Molecular Medicine, Ruďer Bošković Institute, Zagreb, Croatia
N. Mimica
Affiliation:
University Department of Psychiatry, Psychiatric Hospital Vrapče, Zagreb, Croatia School of Medicine, University of Zagreb, Zagreb, Croatia
M. Mustapić
Affiliation:
Division of Molecular Medicine, Ruďer Bošković Institute, Zagreb, Croatia
N. Pivac
Affiliation:
Division of Molecular Medicine, Ruďer Bošković Institute, Zagreb, Croatia
M. Mihanović
Affiliation:
Dartment of Psychiatry, Psychiatric Hospital Sveti Ivan, Zagreb, Croatia
G. Nedić
Affiliation:
Division of Molecular Medicine, Ruďer Bošković Institute, Zagreb, Croatia
V. Folnegović-Šmalc
Affiliation:
University Department of Psychiatry, Psychiatric Hospital Vrapče, Zagreb, Croatia School of Medicine, University of Zagreb, Zagreb, Croatia

Abstract

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Introduction

Alzheimer’ disease (AD) is a complex and progressive neurodegenerative disorder with unclear aetiology. Cognitive impairment and the behavioral disturbances in patients with AD might be associated with altered serotonergic system.

Objectives

Platelet serotonin (5-HT) levels and platelet monoamine oxidase type B (MAO-B) activity might be the biological markers for the progress of AD.

Aims

To determine platelet 5-HT concentrations and MAO-B activity in female patients with mild, moderate or severe stage of AD and sex and age matched healthy controls.

Methods

The study included 106 female patients with the diagnosis of probable AD (DSM-IV-TR and NINCDS-ADRDA criteria), subdivided according to the Mini Mental State Examination (MMSE) score in early (MMSE 26-18), middle (MMSE 17-10) and late (MMSE 9-0) phase of AD. Control group consisted of 102 healthy elderly women (MMSE 30-27). Platelet 5-HT concentrations and MAO-B activity were determined using spectrofluorimetric methods.

Results

Platelet 5-HT concentrations and MAO-B activity were similar between all patients with AD and healthy controls. Patients in the late phase of AD had significantly (p < 0.05) lower platelet 5-HT concentrations and MAO-B activity than patients in other phases of AD and healthy controls. The significant correlations were found between MMSE scores and platelet 5-HT concentrations, MAO-B activity and age.

Conclusion

The results suggest that platelet 5-HT concentration and MAO-B activity might be the peripheral biological markers for the severity and/or clinical progress of AD.

Type
P01-491
Information
European Psychiatry , Volume 26 , Issue S2: Abstracts of the 19th European Congress of Psychiatry , March 2011 , pp. 495
Copyright
Copyright © European Psychiatric Association2011
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