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Differences in plasma concentration of acylethanolanydes and acylglycerols in paired samples of bipolar patients and first- and second-degree relatives

Published online by Cambridge University Press:  23 March 2020

P. Romero-Sanchiz ,
J. Guzman-Parra ,
F. Mayoral-Cleríes ,
F. Rivas-Guerrero ,
P. Araos-Gómez ,
M. Pedraz-Fernández ,
A. Serrano-Criado ,
F.J. Pavón-Morón ,
R. De la Torre-Fornell  and
A. Pastor-Bosch
...Show all authors
P. Romero-Sanchiz*
Affiliation:
IBIMA, Hospital Regional Universitary Málaga, Mental Health, Málaga, Spain
J. Guzman-Parra
Affiliation:
IBIMA, Hospital Regional Universitary Málaga, Mental Health, Málaga, Spain
F. Mayoral-Cleríes
Affiliation:
IBIMA, Hospital Regional Universitary Málaga, Mental Health, Málaga, Spain
F. Rivas-Guerrero
Affiliation:
IBIMA, Hospital Regional Universitary Málaga, Mental Health, Málaga, Spain
P. Araos-Gómez
Affiliation:
IBIMA, Neuropsychopharmacology, Málaga, Spain
M. Pedraz-Fernández
Affiliation:
IBIMA, Neuropsychopharmacology, Málaga, Spain
A. Serrano-Criado
Affiliation:
IBIMA, Neuropsychopharmacology, Málaga, Spain
F.J. Pavón-Morón
Affiliation:
IBIMA, Neuropsychopharmacology, Málaga, Spain
R. De la Torre-Fornell
Affiliation:
IMIM, Integrated Pharmacology and Systems Neurosciences, Barcelona, Spain
A. Pastor-Bosch
Affiliation:
IMIM, Integrated Pharmacology and Systems Neurosciences, Barcelona, Spain
F. Rodríguez de Fonseca
Affiliation:
IBIMA, Neuropsychopharmacology, Málaga, Spain
*
* Corresponding author.

Abstract

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Introduction

Endocannabinoid System (ECS) has been highlighted as one of the most relevant research topics by neurobiologists, pharmacists, basic scientists and clinicians (Skaper and Di Marzo, 2012). Recent work has associated major depressive disorder with the ECS (Ashton and Moore, 2011). Despite the close relationship between depression and bipolar disorders, as far as we know, there is no characterization of ECS and congeners in a sample of patients with bipolar disorders.

Aims and objectives

The objective of this work is to characterize the plasma levels of endocannabinoids and congeners in a sample of patients with bipolar disorders.

Method

The clinical group was composed by 19 patients with a diagnosis of bipolar disorders using SCID-IV (First et al., 1999). The control group was formed by 18 relatives of first- or second-degree of the patients.

The following endocannabinoids and congeners were quantified: N-palmitoleoylethanolamide (POEA), N-palmitolylethanolamide (PEA), N-oleoylethanolamide (OEA), N-stearoylethanolamide (SEA), N-arachidonoylethanolamide (AEA), N-dihomo-γ-linolenoylethanolamide (DGLEA), N-docosatetraenoylethanolamide (DEA), N-linoleoylethanolamide (LEA), N-docosahexaenoylethanolamide (DHEA), 2-arachidonoylglycerol (2-AG), 2-linoleoylglycerol (2-LG), and 2-oleoylglycerol (2-OG).

Results

The result showed statistically significant lower levels of AEA, DEA and DHEA in clinical sample. Previous research also identified lower levels of AEA in depressed women (Hill et al., 2008, 2009). Until date, it is unknown if DEA and DHEA have some effect on EC receptors, and whether they have some direct effects on endocannabinoids.

Conclusions

It would be necessary to carry our other research with a larger sample, which could allow the control of potential confounding variables.

Disclosure of interest

The authors have not supplied their declaration of competing interest.

Type
EV206
Information
European Psychiatry , Volume 33 , Issue S1: Abstracts of the 24th European Congress of Psychiatry , March 2016 , pp. S340
Copyright
Copyright © European Psychiatric Association 2016
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