High disgust sensitivity and poor cognitive flexibility have been independently identified as contributing factors in the aetiology of obsessive-compulsive disorder. This study looks at the relationship between contamination fear and disgust sensitivity in a non-clinical population. In particular, at whether two moderating factors, cognitive flexibility and emotional reappraisal, have a buffering influence. One hundred participants from an undergraduate population completed a battery of questionnaires which rated their disgust and level of contamination fear. They also completed a set-shifting task to assess cognitive flexibility and an emotion regulation questionnaire. The mean age of the sample was 21.4 years with 62% of the sample population being female. SPSS 16 was used to correlate the main variables using Pearson's correlation and moderated regression, using MODPROBE, was used for analysis. Results confirmed previous findings that high disgust sensitivity is significantly associated with contamination fear (P < 0.01). In addition to this, both cognitive flexibility and emotional reappraisal reduced the influence that disgust has on an individual's contamination fear. Cognitive flexibility and emotion reappraisal were not found to be significantly correlated to each other (P = 0.511), which suggest that these variables moderate the relationship between disgust and contamination fear independently of each other. Individuals with poor cognitive flexibility and/or poor emotional reappraisal were found to have high levels of contamination fear, which suggests that these two variables may attenuate the relationship between disgust and contamination fear. Future implications of these findings have been discussed although further research is needed to confirm these conclusions in a clinical population.