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EPA-0048 - Relationships Between Serum Total Antioxidant Capacity and Typical/atypical Antipsychotic Treatment in Acute Paranoid Schizophrenia

Published online by Cambridge University Press:  15 April 2020

E. Diaz-Mesa ,
A. Morera-Fumero ,
P. Abreu-Gonzalez ,
M. Henry-Benitez ,
L. Fernandez-Lopez ,
S. Yelmo-Cruz  and
R. Gracia-Marco
E. Diaz-Mesa
Affiliation:
Psychiatry, University Hospital of the Canary Islands, SANTA CRUZ DE TENERIFE, Spain
A. Morera-Fumero
Affiliation:
Internal Medicine Dermatology and Psychiatry, School of Medicine, University of La Laguna
P. Abreu-Gonzalez
Affiliation:
Physiology, School of Medicine. University of La Laguna, Santa Cruz de Tenerife, Spain
M. Henry-Benitez
Affiliation:
Psychiatry, University Hospital of the Canary Islands, SANTA CRUZ DE TENERIFE, Spain
L. Fernandez-Lopez
Affiliation:
Internal Medicine Dermatology and Psychiatry, School of Medicine, University of La Laguna
S. Yelmo-Cruz
Affiliation:
Psychiatry, University Hospital of the Canary Islands, SANTA CRUZ DE TENERIFE, Spain
R. Gracia-Marco
Affiliation:
Psychiatry, University Hospital of the Canary Islands, SANTA CRUZ DE TENERIFE, Spain

Abstract

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Introduction:

Schizophrenia is a chronic disease characterized by disturbances of thought, perception, volition, affectivity and cognition. An imbalance of the oxidant-antioxidant system is one of the proposed etiological factors. There are controversies regarding the effect of antipsychotics on the oxidant-antioxidant balance.

Objective:

The aim of this research is to study the serum levels of the total antioxidant capacity (TAC) in paranoid schizophrenia patients treated with typical and/or atypical antipsychotics.

Methods:

The sample is comprised by 38 patients admitted to the psychiatric ward of the University Hospital of the Canary Islands. All patients met DSM-IV criteria for paranoid schizophrenia. Some patients were treated only with atypical antipsychotics (N=21) while others were treated with a combination of atypical and typical antipsychotics (N=17).

Results:

The next table shows the comparison of serum TAC levels at admission (TAC-A) and discharge (TAC-D) at 12:00 and 00:00 h.

 AntipsychoticsMeanS.DP
TAC-A-12Only Atypical0.66330.142150.952
Typical+Atypical0.66040.14889
TAC-A-00Only Atypical0.60040.150620.626
Typical+Atypical0.62470.16163
TAC-D-12Only Atypical0.60700.160670.019
Typical+Atypical0.71720.07654
TAC-D-00Only Atypical0.60010.161710.153
Typical+Atypical0.68360.07842

Patients treated with a combination of typical and atypical antipsychotics present at discharge (12:00 hours) significantly higher levels of TAC than patients treated only with typical antipsychotics. The remaining comparisons did not elicit significant results.

Conclusions:

The results point out the fact that a combination of typical and atypical antipsychotics is more helpful in reducing the deficits of the antioxidant system than treatments based only on typical antipsychotics.

Type
EPW01 - Schizophrenia 1
Information
European Psychiatry , Volume 29 , Issue S1: Abstracts of the 22nd European Congress of Psychiatry , 2014 , pp. 1
Copyright
Copyright © European Psychiatric Association 2014
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