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P01-223 - A Study on the Polymorphism of DRD4exoniii48bp VNTR and Executive Function in Han Chinese children with Tourette's Syndrome

Published online by Cambridge University Press:  17 April 2020

J. Weidong ,
Z. Guoquan ,
Z. Jiaxiu ,
Y. Chuang ,
G. Tianyou  and
G. Lanting
J. Weidong
Affiliation:
Shanghai Changning Mental Health Center, Shanghai
Z. Guoquan
Affiliation:
Shanghai Changning Mental Health Center, Shanghai
Z. Jiaxiu
Affiliation:
Shenzhen Children Hospital, Shenzhen
Y. Chuang
Affiliation:
Wenzhou Medical College, Wenzhou
G. Tianyou
Affiliation:
West China University of Medical Science, China
G. Lanting
Affiliation:
West China Hospital, Chengdu, China

Abstract

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Objective

The relationship of DRD4exonIII48bp VNTR and executive function were studied in 86 children with Tourette's Syndrome.

Methods

86 Han Chinese children with GTS were tested using a set of neuropsychological test(Stroop test, trail making test,modified Wisconsin Card sorting test) and compared with 51 healthy control group to understand the relationship between executive deficits and genetics.

Results

Compared with normal children, The GTS group showed impairment on almost all psychological measures. In some stroop test, combined ADHD group differed from the GTS-alone group. No evidence show significantly difference among DRD4exonIII48bp VNTR and executive function.

Conclusion

GTS patient has executive function deficits,these deficits may have nothing to do with DRD4exonIII48bp VNTR.For comorbid, there is a certain influence in the executive function.

Type
Child and adolescent psychiatry
Information
European Psychiatry , Volume 25 , Issue S1: 18th European Congress of Psychiatry. February 27, March 2, 2010 - Munich, Germany , 2010 , 25-E429
Copyright
Copyright © European Psychiatric Association 2010
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