We report a case of psychotic disorder in a 60-year-old woman diagnosed with uterine cervical cancer who suddenly refused to continue local cobaltotherapy and was twice admitted to a psychiatric hospital for bizarre behavior and delusional-hallucinatory symptomatology, for a total period of almost three months – discontinued by a one week discharge, during which she became noncompliant to treatment and was readmitted.

The laboratory data and the brain computer-tomography were unremarkable. She had no history of psychiatric illness or drug or alcohol abuse.

Her family reports that the onset of delusional speech about her recently diagnosed cancer – preceded the first psychiatric admission by one month.

On psychiatric examination she showed delusional thought with religious, somatic and bizarre content; auditory, including imperative hallucinations, no insight of the psychiatric disorder and denied the oncological diagnostic. During hospitalization she developed persecutory delusions, depressive symptoms, and manifested delusional-hallucinatory modified behavior.

She received treatment with antipsychotic, antidepressant, mood stabilizing and anticholinergic medication. There was an improvement of her mood symptoms and some reduction of the psychotic symptomatology. However, she was still having bizarre somatic and religious delusional ideas and less prominent auditory hallucinations.

At the time of this report the psychotic disorder has a four months evolution, with antipsychotic treatment started three months ago. No oncological treatment was applied after the discontinuation of the local cobaltotherapy.

The psychotic disorder developed by this patient at approximately the same time of histopathological confirmation of the uterine cervical cancer, impaired her oncological therapy and prognosis.