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P03-221 - Somatosensory Cortices Are Required For The Acquisition But Not Retention Of Morphine-Induced Conditioned Place Preference

Published online by Cambridge University Press:  17 April 2020

Z. Meng
Affiliation:
Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, China
C. Liu
Affiliation:
Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, China
X. Hu
Affiliation:
Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, China
Y. Ma
Affiliation:
Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, China

Abstract

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Background

Sensory system information is thought to play an important role in drug addiction related responses. However, how somatic sensory information participates in the drug related behaviors is still unclear. Many studies demonstrated that drug addiction represents a pathological usurpation of neural mechanisms of learning and memory that normally relate to the pursuit of rewards. Thus, elucidate the role of somatic sensory in drug related learning and memory is of particular importance to understand the neurobiological mechanisms of drug addiction.

Principle findings

In the present study, we investigated the role of somatosensory system in reward-related associative learning using the conditioned place preference model. Lesions were made in somatosensory cortices either before or after conditioning training. We found that lesion of somatosensory cortices before, rather than after morphine conditioning impaired the acquisition of place preference.

Conclusion

These results demonstrate that somatosensory cortices are necessary for the acquisition but not retention of morphine induced place preference.

Type
Substance related disorders
Copyright
Copyright © European Psychiatric Association 2010
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